{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:30:05Z","timestamp":1769603405270,"version":"3.49.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim To report our experience with 106ruthenium-brachytherapy of peripheral capillary haemangioblastomas in patients with von Hippel-Lindau disease.<\/jats:p><jats:p>\n          Design Retrospective case series.<\/jats:p><jats:p>\n          Methods A total of 53 haemangioblastomas, treated with 106ruthenium-brachytherapy, were included in our study. The applied radiation dose, visual outcome, angioma activity, need for vitreoretinal surgery and incidence of secondary complications such as macular oedema, secondary glaucoma, vitreous haemorrhage, and epiretinal gliosis were assessed.<\/jats:p><jats:p>\n          Results All treated eyes could be preserved. In 11 patients (20.8%), single brachytherapy did not achieve complete inactivation of the tumour. 31% developed macular oedema postoperatively. Tractional retinal detachment developed in 23.8%, and epiretinal gliosis was observed in 2.4% of patients. Vitreoretinal surgery was necessary in 50% of all treated eyes. At the end of the follow-up, 40.5% of all treated eyes achieved visual acuity (VA) of 0.6 or better, and one third reached a VA of less than 0.1. Mean irradiation dose to the tumour apex was 144\u2009Gy. Higher apex doses correlated with better tumour control of irradiated haemanigoblastomas and lower complication rates.<\/jats:p><jats:p>\n          Conclusions Brachytherapy of peripheral retinal capillary haemangioblastomas is an effective treatment modality. Higher irradiation doses seem to lead to more successful treatment.<\/jats:p>","DOI":"10.1055\/a-1391-9110","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T22:30:28Z","timestamp":1628634628000},"page":"781-787","source":"Crossref","is-referenced-by-count":9,"title":["Brachytherapy for Peripheral Retinal Capillary Haemangioblastoma in von Hippel-Lindau Disease"],"prefix":"10.1055","volume":"238","author":[{"given":"Sami","family":"Dalbah","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos E.","family":"Bechrakis","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Thomasen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Fl\u00fchs","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Strahlentherapie, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Rating","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Guberina","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Strahlentherapie, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Stuschke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Strahlentherapie, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-5167","authenticated-orcid":false,"given":"Miltiadis","family":"Fiorentzis","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Bornfeld","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Biewald","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1007\/s00381-020-04712-5","article-title":"Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment","volume":"36","author":"J H Klingler","year":"2020","journal-title":"Childs Nerv Syst"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10689-004-1327-0","article-title":"Ophthalmological manifestations in VHL and NF 1: pathological and diagnostic implication","volume":"4","author":"K M Kreusel","year":"2005","journal-title":"Fam Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1097\/IAE.0000000000002572","article-title":"Management of Retinal Hemangioblastoma in Von Hippel-Lindau Disease","volume":"39","author":"H E Wiley","year":"2019","journal-title":"Retina"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene","volume":"260","author":"F Latif","year":"1993","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0140-6736(03)13643-4","article-title":"von Hippel-Lindau disease","volume":"361","author":"R R Lonser","year":"2003","journal-title":"Lancet"},{"key":"ref6","first-page":"78","article-title":"Von Hippel-Lindau Disease and the Eye","volume":"15","author":"S Karimi","year":"2020","journal-title":"J Ophthalmic Vis Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1007\/s004170000200","article-title":"Retinal angiomatosis and von Hippel-Lindau disease","volume":"238","author":"K M Kreusel","year":"2000","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref8","first-page":"e5319","article-title":"Ocular Manifestations of von Hippel-Lindau Disease","volume":"11","author":"M D Ruppert","year":"2019","journal-title":"Cureus"},{"key":"ref9","first-page":"114","article-title":"[Capillary hemangioma of the retina in cases of von Hippel-Lindau syndrome. 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