{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:41Z","timestamp":1740126881639,"version":"3.37.3"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Mortalit\u00e4t von Patienten mit isoliert auftretenden angeborenen Zwerchfellhernien liegt in spezialisierten Zentren bei 20\u201340%. Wesentliche, das Outcome beeinflussende Faktoren, sind die bestehende Lungenhypoplasie, eine daraus resultierende pulmonale Hypertonie, sowie das Vorliegen weiterer Fehlbildungen. Begleitfehlbildungen wie angeborene Herzfehler treten bei ca. 18% aller Neonaten mit Zwerchfellhernie auf. Schwere angeborene Herzfehler wie das hypoplastische Linksherz Syndrom zeigen sich in ca. 8% der F\u00e4lle. In einer retrospektiven Analyse des Patientenkollektivs unserer Klinik zwischen 01\/2012 und 12\/2018 wurde das pr\u00e4- und postnatale Management, sowie das Outcome von Neugeborenen mit der Kombination aus angeborenen Herzfehlern und Zwerchfellhernien untersucht. Im Studienzeitraum wurden in unserer Klinik 156 Neugeborene mit Zwerchfellhernie behandelt. Bei 10 Patienten (6,4%) lag zus\u00e4tzlich ein schwerer, bei 11 Patienten (7,1%) ein moderater Herzfehler vor. 6\/21 Patienten verstarben im Verlauf des Krankenhausaufenthaltes, davon 3 am ersten Lebenstag. Es zeigte sich eine deutlich geringere Mortalit\u00e4t bei Patienten mit Zwerchfellhernie und moderatem Herzfehler im Vergleich zu schwerem Herzfehler (9 vs. 50%). Besonders hoch lag die Mortalit\u00e4t bei Kindern mit einem univentrikul\u00e4ren Herzen. Trotz einer deutlich reduzierten Prognose bei der Kombination aus angeborenem Herzfehler und Zwerchfellhernie muss nicht generell mit einer infausten Prognose gerechnet werden. In spezialisierten Zentren kann ein kurativer Ansatz erfolgen.<\/jats:p>","DOI":"10.1055\/a-1392-1460","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T01:18:26Z","timestamp":1615425506000},"page":"432-440","source":"Crossref","is-referenced-by-count":1,"title":["Therapie und Outcome von Neugeborenen mit kongenitaler Zwerchfellhernie und angeborenen Herzfehlern"],"prefix":"10.1055","volume":"225","author":[{"given":"Julian","family":"Balks","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Neonatologie und P\u00e4diatrische Intensivmedizin, Universit\u00e4tsklinikum Bonn, Bonn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Mueller","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Neonatologie und P\u00e4diatrische Intensivmedizin, Universit\u00e4tsklinikum Bonn, Bonn, 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