{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:41Z","timestamp":1740126881979,"version":"3.37.3"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\nEinleitung Dreiviertel aller Geb\u00e4renden erhalten w\u00e4hrend der Geburt eine Analgesie. Es stehen regionale und systemische Analgesieverfahren zur Verf\u00fcgung. Diese \u00dcbersichtsarbeit analysiert die Datenlage zu den Auswirkungen einer geburtshilflichen Analgesie mit systemischen Opioiden auf das Neugeborene.<\/jats:p><jats:p>\nMethoden Die Datenbanken PubMed und Cochrane Library wurden nach den folgenden Begriffen durchsucht: \u201eMeptazinol\u201c, \u201eMeptid\u201c, \u201eanalgesia\u201c, \u201epainkiller\u201c, \u201epain reliever\u201c, \u201eobstetrics\u201c, \u201elabor\u201c, \u201elabour\u201c, \u201edelivery\u201c, \u201eneonate\u201c, \u201enewborn\u201c, \u201echild\u201c, \u201ebaby\u201c, \u201einfant\u201c, \u201efetus\u201c, \u201efetal\u201c, \u201eopioid\u201c und \u201eopiate\u201c sowie zus\u00e4tzlich eine MeSH Terms Suche in PubMed durchgef\u00fchrt.<\/jats:p><jats:p>\nErgebnisse Von 355 potenziell relevanten Studien wurden 23 Studien in diese Arbeit eingeschlossen. Die Studien variierten stark in Qualit\u00e4t, Stichprobengr\u00f6\u00dfe und Outcome-Kriterien. Das neonatale Outcome war h\u00e4ufig nur ein sekund\u00e4rer Endpunkt. Selten wurden signifikante Unterschiede bezogen auf das Outcome der Neugeborenen zwischen den verschiedenen systemischen Opioiden oder im Vergleich zu Kontrollgruppen berichtet. In 12 Studien wurden die APGAR-Werte der Neugeborenen zwischen Behandlungsgruppen verglichen, wobei sich bei 10 (83%) dieser Studien keine Unterschiede zeigten.<\/jats:p><jats:p>\nDiskussion\/Ausblick Die Evidenzlage zu Auswirkungen geburtshilflicher Analgesie mit systemischen Opioiden ist insgesamt gering und Studien zum Langzeit-Outcome von Neugeborenen fehlen. Auch die Frage, ob eine postnatale \u00dcberwachung der Neugeborenen notwendig ist, kann nicht klar beantwortet werden. Studien mit prospektivem Studiendesign sollten durchgef\u00fchrt werden.<\/jats:p>","DOI":"10.1055\/a-1392-1773","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T23:40:20Z","timestamp":1616456420000},"page":"473-483","source":"Crossref","is-referenced-by-count":1,"title":["Auswirkungen geburtshilflicher Analgesie mit systemischen Opioiden auf das Neugeborene \u2013 eine \u00dcbersichtsarbeit"],"prefix":"10.1055","volume":"225","author":[{"given":"Berenike","family":"Seiler","sequence":"first","affiliation":[{"name":"Sektion Neonatologie und P\u00e4diatrische Intensivmedizin, Zentrum f\u00fcr Geburtshilfe, Kinder- und Jugendmedizin, Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-754X","authenticated-orcid":false,"given":"Philipp","family":"Deindl","sequence":"first","affiliation":[{"name":"Sektion Neonatologie und P\u00e4diatrische Intensivmedizin, Zentrum f\u00fcr Geburtshilfe, Kinder- und Jugendmedizin, Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Somville","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Geburtshilfe und Pr\u00e4natalmedizin, Zentrum f\u00fcr Geburtshilfe, Kinder- und Jugendmedizin, Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinedu Ulrich","family":"Ebenebe","sequence":"additional","affiliation":[{"name":"Sektion Neonatologie und P\u00e4diatrische Intensivmedizin, Zentrum f\u00fcr Geburtshilfe, Kinder- und Jugendmedizin, Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Hecher","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Geburtshilfe und Pr\u00e4natalmedizin, Zentrum f\u00fcr Geburtshilfe, Kinder- und Jugendmedizin, Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Singer","sequence":"additional","affiliation":[{"name":"Sektion Neonatologie und P\u00e4diatrische Intensivmedizin, Zentrum f\u00fcr Geburtshilfe, Kinder- und Jugendmedizin, Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"edition":"4. 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