{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:59:45Z","timestamp":1787065185950,"version":"build-2736575974"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objectives This study aimed to evaluate the current situation of\nhypoparathyroid patients and to investigate the relationship between\ntreatment adherence and quality of life.<\/jats:p>\n                  <jats:p>Study design Prospective, multicentre study.<\/jats:p>\n                  <jats:p>Methods Adult patients presenting with the diagnosis of\nhypoparathyroidism to 20 different endocrinology clinics were included. They\nwere receiving conventional therapies for hypoparathyroidism, using calcium,\nactive vitamin D, and magnesium. We collected data on demographic features,\ndisease- and treatment-related information, and results of routine\nlaboratory tests, treatment adherence, and presence of complications. Beck\nDepression Inventory, Beck Anxiety Inventory, and Short Form-36 quality of\nlife assessments were administered.<\/jats:p>\n                  <jats:p>Results Among the 300 patients studied, 60.7% were adherent\nto their treatment, and 34.1% had complications. Anxiety and\ndepression scores were significantly higher in non-adherent versus\ntreatment-adherent patients (p&lt;0.001 and p=0.001,\nrespectively). Most of the domains of quality-of-life scores were also\nsignificantly lower in non-adherent patients. Both anxiety and depression\nscores showed significant, negative correlations with serum calcium and\nmagnesium concentrations (r=\u22120.336, p&lt;0.001\nand r=\u22120.258, p&lt;0.001, respectively).<\/jats:p>\n                  <jats:p>Conclusions Nearly 40% of the patients were non-adherent to\nconventional treatment for hypoparathyroidism, and such patients had higher\nanxiety and depression scores and poorer quality of life scores.\nConventional treatment might not be sufficient to meet the needs of patients\nwith hypoparathyroidism. In addition to seeking new therapeutic options,\nfactors influencing quality of life should also be investigated and\nstrategies to improve treatment adherence should be developed.<\/jats:p>","DOI":"10.1055\/a-1400-2668","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T20:14:32Z","timestamp":1615407272000},"page":"918-925","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Treatment Adherence on Quality of Life in Hypoparathyroid\nPatients"],"prefix":"10.1055","volume":"129","author":[{"given":"Inan","family":"Anaforoglu","sequence":"additional","affiliation":[{"name":"Bahcesehir University, Faculty of Medicine, Department of Internal\nDiseases, Endocrinology Clinic, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Sancak","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Fatih Sultan Mehmet Education and\nResearch Hospital, Endocrinology and Metabolism Disorders, Department of\nInternal Medicine, \u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emin Murat","family":"Akbas","sequence":"additional","affiliation":[{"name":"Erzincan Binali Y\u0131ld\u0131r\u0131m University,\nMeng\u00fccek Gazi Training and Research Hospital, Department of Internal\nDiseases, Endocrinology Clinic, Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guzide Gonca","family":"Oruk","sequence":"additional","affiliation":[{"name":"Izmir Katip Celebi University, Ataturk Training and Research Hospital,\nDepartment of Internal Diseases, Endocrinology Clinic, Izmir,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masum","family":"Canat","sequence":"additional","affiliation":[{"name":"Health Sciences University Sisli Hamidiye Etfal Training and Research\nHospital, Department of Internal Diseases, Endocrinology Clinic, Istanbul,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadriye Ayd\u0131n","family":"Tezcan","sequence":"additional","affiliation":[{"name":"Kartal Dr. L\u00fctfi Kirdar City Hospital, Department of Internal\nDiseases, Endocrinology Clinic, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziynet Alphan","family":"Uc","sequence":"additional","affiliation":[{"name":"Usak Training and Research Hospital, Department of Internal Diseases,\nEndocrinology Clinic, Usak, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suheyla","family":"Gorar","sequence":"additional","affiliation":[{"name":"Health Sciences University, Antalya Training and Research Hospital,\nDepartment of Internal Diseases, Endocrinology Clinic, Antalya,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulhan Cavlak","family":"Duman","sequence":"additional","affiliation":[{"name":"Sivas Cumhuriyet University Health Services Practice and Research\nHospital, Department of Internal Diseases, Endocrinology Clinic, Adana,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guzin Fidan","family":"Yaylali","sequence":"additional","affiliation":[{"name":"Pamukkale University Hospitals, Department of Internal Diseases,\nEndocrinology Clinic, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Samsun Gazi State Hospital, Department of Internal Diseases,\nEndocrinology Clinic, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul Ekiz","family":"Bilir","sequence":"additional","affiliation":[{"name":"Tekirdag State Hospital, Department of Internal Diseases, Endocrinology\nClinic, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humeyra","family":"Bozoglan","sequence":"additional","affiliation":[{"name":"Giresun University Prof. Dr. A. Ilhan Ozdemir Training and Research\nHospital, Department of Internal Diseases, Endocrinology Clinic, Giresun,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulhan","family":"Akbaba","sequence":"additional","affiliation":[{"name":"Mugla Sitki Kocman University Training and Research Hospital,\nDepartment of Internal Diseases, Endocrinology Clinic, Mugla,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazhar Muslum","family":"Tuna","sequence":"additional","affiliation":[{"name":"Umraniye Training and Research Hospital, Department of Internal\nDiseases, Endocrinology Clinic, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seckin","family":"Akcay","sequence":"additional","affiliation":[{"name":"Umraniye Training and Research Hospital, Department of Internal\nDiseases, Endocrinology Clinic, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Tuzun","sequence":"additional","affiliation":[{"name":"Kahramanmaras Sutcu Imam University Health Practice and Research\nHospital, Department of Internal Diseases, Endocrinology Clinic, Kahramanmaras,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulay Simsek","family":"Bagir","sequence":"additional","affiliation":[{"name":"Baskent University Adana Dr. Turgut Noyan Practice and Research Center,\nDepartment of Internal Diseases, Endocrinology Clinic, Adana,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiz Eksi","family":"Haydardedeoglu","sequence":"additional","affiliation":[{"name":"Baskent University Adana Dr. Turgut Noyan Practice and Research Center,\nDepartment of Internal Diseases, Endocrinology Clinic, Adana,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsah","family":"Elbuken","sequence":"additional","affiliation":[{"name":"Nam\u0131k Kemal University, Faculty of Medicine, Department of\nInternal Medicine, Endocrinology Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goknur","family":"Yorulmaz","sequence":"additional","affiliation":[{"name":"Eskisehir Osmangazi University Health, Practice and Research Hospital,\nDepartment of Internal Diseases, Endocrinology Clinic, Eskisehir,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Celik","sequence":"additional","affiliation":[{"name":"Mehmet Ali Ayd\u0131nlar Ac\u0131badem University, Faculty of\nMedicine, Department of Internal Diseases, Endocrinology Clinic,\n\u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Topbas","sequence":"additional","affiliation":[{"name":"Karadeniz Technical University, Faculty of Medicine, Department of\nPublic Health, Trabzon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/BOR.0000000000000618","article-title":"Update on hypoparathyroidism","volume":"31","author":"N E Cusano","year":"2019","journal-title":"Curr Opin Rheumatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12020-017-1377-3","article-title":"Quality of life in patients with hypoparathyroidism receiving standard\ntreatment: A systematic review","volume":"58","author":"M B\u00fcttner","year":"2017","journal-title":"Endocrine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1210\/clinem\/dgaa113","article-title":"Hypoparathyroidism","volume":"105","author":"J P Bilezikian","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1210\/jc.2015-3909","article-title":"Presentation of hypoparathyroidism: Etiologies and clinical features","volume":"101","author":"D M Shoback","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-15-0628","article-title":"European Society of Endocrinology. European Society of Endocrinology Clinical\nGuideline: Treatment of chronic hypoparathyroidism in adults","volume":"173","author":"J Bollerslev","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s12020-017-1479-y","article-title":"Quality of life in hypoparathyroidism","volume":"59","author":"L Rejnmark","year":"2018","journal-title":"Endocrine"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"A T Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"ref8","first-page":"118","article-title":"Beck depresyon envanteri\u2019nin ge\u00e7erlili\u011fi \u00fczerine\nbir \u00e7al\u0131\u015fma","volume":"6","author":"N Hisli","year":"1988","journal-title":"Psikoloji Dergisi"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1037\/0022-006X.56.6.893","article-title":"An inventory for measuring clinical anxiety: Psychometric properties","volume":"56","author":"A T Beck","year":"1988","journal-title":"J Consult Clin Psychol"},{"key":"ref10","first-page":"163","article-title":"Turkish version of the Beck anxiety inventory: Psychometric properties","volume":"12","author":"M Ulusoy","year":"1998","journal-title":"J Cognit Psychother"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and\nitem selection","volume":"30","author":"J E Ware","year":"1992","journal-title":"Med Care"},{"key":"ref12","first-page":"102","article-title":"K\u0131sa Form-36 (KF-36)\u2019n\u0131n T\u00fcrk\u00e7e\nversiyonunun g\u00fcvenilirli\u011fi ve ge\u00e7erlili\u011fi","volume":"12","author":"H Ko\u00e7yi\u011fit","year":"1999","journal-title":"\u0130la\u00e7 ve Tedavi Dergisi"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/PROM.S179310","article-title":"Psychometric evaluation of the hypoparathyroidism symptom diary","volume":"10","author":"T Coles","year":"2019","journal-title":"Patient Relat Outcome Meas"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s40271-019-00388-5","article-title":"Assessing the patient experience of hypoparathyroidism symptoms: Development of\nthe hypoparathyroidism patient experience scale-symptom (HPES-symptom)","volume":"13","author":"M Brod","year":"2020","journal-title":"Patient"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1007\/s12325-019-00999-2","article-title":"Development of a patient- reported outcome measure for chronic\nhypoparathyroidism","volume":"36","author":"S Martin","year":"2019","journal-title":"Adv Ther"},{"key":"ref16","first-page":"e10245","article-title":"The HPQ-development and first administration of a questionnaire for\nhypoparathyroid patients","volume":"7","author":"D Wilde","year":"2019","journal-title":"JBMR Plus"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"671","DOI":"10.4158\/EP13328.OR","article-title":"Understanding the burden of illness associated with hypoparathyroidism reported\namong patients in the PARADOX study","volume":"20","author":"N Hadker","year":"2014","journal-title":"Endocr Pract"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.beem.2018.09.007","article-title":"Clinical presentation and management of hypoparathyroidism","volume":"32","author":"G Marcucci","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1530\/EJE-18-0580","article-title":"Long-term complications in patients with chronic hypoparathyroidism: A\ncross-sectional study","volume":"180","author":"K David","year":"2019","journal-title":"Eur J Endocrinol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/1752-1947-8-326","article-title":"Mood disorder as a manifestation of primary hypoparathyroidism: A case\nreport","volume":"8","author":"R G Rosa","year":"2014","journal-title":"J Med Case Rep"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1530\/eje.0.1460215","article-title":"Well-being, mood and calcium homeostasis in patients with hypoparathyroidism\nreceiving standard treatment with calcium and vitamin D","volume":"146","author":"W Arlt","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"ref22","first-page":"319","article-title":"Self-report of psychological symptoms in hypoparathyroidism patients on\nconventional therapy","volume":"62","author":"A J Arneiro","year":"2018","journal-title":"Arch Endocrinol Metab"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1002\/jbmr.2273","article-title":"Postsurgical hypoparathyroidism\u2014risk of fractures, psychiatric diseases,\ncancer, cataract, and infections","volume":"29","author":"L Underbjerg","year":"2014","journal-title":"J Bone Miner Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1210\/jc.2016-1477","article-title":"Epidemiology and health-related quality of life in hypoparathyroidism in\nNorway","volume":"101","author":"M C Astor","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1007\/s12325-019-01102-5","article-title":"Defining the characteristics of chronic hypoparathyroidism not adequately\ncontrolled on conventional therapy: Consensus findings of three European Delphi\npanels","volume":"36","author":"K Iqbal","year":"2019","journal-title":"Adv Ther"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.ecl.2018.07.010","article-title":"Quality of life in hypoparathyroidism","volume":"47","author":"T J Vokes","year":"2018","journal-title":"Endocrinol Metab Clin North Am"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/cen.13593","article-title":"Health-related quality of life in patients with nonsurgical hypoparathyroidism\nand pseudohypoparathyroidism","volume":"88","author":"L Underbjerg","year":"2018","journal-title":"Clin Endocrinol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11657-020-00759-8","article-title":"The effects of patient and disease-related factors on the quality of life in\npatients with hypoparathyroidism","volume":"15","author":"S Hepsen","year":"2020","journal-title":"Arch Osteoporos"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s42000-020-00186-x","article-title":"Quality of life of patients more than 1 year after surgery for thyroid\ncancer","volume":"19","author":"M B\u00fcttner","year":"2020","journal-title":"Hormones (Athens, Greece)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1002\/jbmr.2812","article-title":"Concurrent hypoparathyroidism is associated with impaired physical function and\nquality of life in hypothyroidism","volume":"1","author":"T Sikjaer","year":"2016","journal-title":"J Bone Miner Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/cen.14128","article-title":"Burden of illness in not adequately controlled chronic hypoparathyroidism:\nFindings from a 13-country patient and caregiver survey","volume":"92","author":"H Siggelkow","year":"2020","journal-title":"Clin Endocrinol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1530\/EJE-18-0609","article-title":"Standards of care for hypoparathyroidism in adults","volume":"180","author":"A A Khan","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1210\/jc.2013-1239","article-title":"The effect of PTH(1-84) on quality of life in hypoparathyroidism","volume":"98","author":"N E Cusano","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1210\/jc.2014-2267","article-title":"PTH(1-84) is associated with improved quality of life in hypoparathyroidism\nthrough 5 years of therapy","volume":"99","author":"N E Cusano","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00198-014-2677-6","article-title":"Effects of PTH(1-84) therapy on muscle function and quality of life in\nhypoparathyroidism: Results from a randomized controlled trial","volume":"25","author":"T Sikjaer","year":"2014","journal-title":"Osteoporos Int"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1210\/jc.2017-01555","article-title":"PTH(1-34) for Surgical hypoparathyroidism: A 2-year prospective, open-label\ninvestigation of efficacy and quality of life","volume":"103","author":"A Palermo","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1210\/jc.2018-02430","article-title":"Quality of life in hypoparathyroidism improves with rhPTH(1-84) throughout 8\nyears of therapy","volume":"104","author":"G Tabacco","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1210\/jc.2017-01471","article-title":"Recombinant human parathyroid hormone effect on health-related quality of life\nin adults with chronic hypoparathyroidism","volume":"103","author":"T J Vokes","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1210\/jc.2017-02593","article-title":"replacement therapy improve quality of life in patients with chronic\nhypoparathyroidism?","volume":"103","author":"K K Winer","year":"2018","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1400-2668.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T18:57:12Z","timestamp":1638817032000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1400-2668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,10]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12,6]]},"published-print":{"date-parts":[[2021,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1400-2668","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,10]]}}}