{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T06:53:35Z","timestamp":1686898415822},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2002Hashimoto\u2019s thyroiditis is a common disease that also affects pregnant women. We analyzed to what extent the inflammatory process of Hashimoto\u2019s thyroiditis changes with iodine prophylaxis in pregnant women. The target for immunologic activity was levels of thyroid antibodies (TPO).<\/jats:p><jats:p>\n          Methods\u2002The data were collected retrospectively from 20\u00a0consecutive, pregnant patients who had been diagnosed with Hashimoto\u2019s thyroiditis between 01.12.2012 and 01.12.2014 and had received iodine supplementation with 100\u200a\u00b5g (n\u200a=\u200a1) or 150\u200a\u00b5g (n\u200a=\u200a19). At least two measurements of TPO antibody levels taken during pregnancy and one after pregnancy were evaluated for each patient in the study group.<\/jats:p><jats:p>\n          Results\u2002At the end of pregnancy, the average TPO antibody level for the 20 patients studied was 137\u200aIU\/ml (+\/\u2013214\u200aIU\/ml), the lowest being 16\u200aIU\/ml and the highest 1000\u200aIU\/ml. Despite iodine prophylaxis, levels of TPO antibodies decreased in 18 patients during pregnancy, falling below the reference value of 35\u200aIU\/ml in 5 cases. However, in one patient TPO antibodies increased from 60\u200aIU\/ml to 237\u200aIU\/ml during pregnancy while in another, levels remained constant at 1000\u200aIU\/ml.<\/jats:p><jats:p>\n          Conclusion\u2002Iodine prophylaxis in pregnant women, taken at a dose of 100 or 150 \u03bcg daily was shown to have no negative systemic effects on Hashimoto\u2019s thyroiditis in a group of pregnant women with increased TPO levels, and can therefore be recommended for expectant mothers, including those with this disease.<\/jats:p>","DOI":"10.1055\/a-1400-3522","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:11:40Z","timestamp":1616544700000},"page":"266-271","source":"Crossref","is-referenced-by-count":2,"title":["Avoidance of iodine deficiency\/excess during pregnancy in Hashimoto\u2019s thyroiditis"],"prefix":"10.1055","volume":"60","author":[{"given":"Lutz","family":"van Heek","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Staudacher","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Faust","sequence":"additional","affiliation":[{"name":"Center for Endocrinology, Diabetes and Preventive Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costanza","family":"Chiapponi","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Tumor and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Mettler","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Drzezga","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Dietlein","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Kobe","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref1","volume-title":"Basislehrbuch Innere Medizin","author":"H Renz-Polster","year":"2004"},{"key":"ref2","first-page":"4","volume-title":"Thyroid (dys)function in normal and disturbed pregnancy","author":"B K Budenhofer","year":"2012"},{"key":"ref3","first-page":"6","volume-title":"Schilddr\u00fcsenerkrankungen","author":"W Meng","year":"2002","edition":"4. 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