{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:39:34Z","timestamp":1787884774798,"version":"build-2784847793"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"Beijing Key Clinical Specialty for Laboratory Medicine - Excellent Project","award":["No. ZK201000"],"award-info":[{"award-number":["No. ZK201000"]}]},{"name":"China Capital Health Research and Development of Special Project","award":["2020\u20131\u20134014"],"award-info":[{"award-number":["2020\u20131\u20134014"]}]},{"name":"Chinese Geriatrics Society: Specification for real world data processing in clinical laboratory","award":["T\/CGSS 014\u20132018"],"award-info":[{"award-number":["T\/CGSS 014\u20132018"]}]},{"DOI":"10.13039\/501100019018","name":"CAMS Initiative for Innovative Medicine","doi-asserted-by":"crossref","award":["2016-I2 M-1-008"],"award-info":[{"award-number":["2016-I2 M-1-008"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thyroid hormone reference intervals are crucial for diagnosing and monitoring thyroid dysfunction during early pregnancy, and the dynamic change trend of thyroid hormones during pregnancy can assist clinicians to assess the thyroid function of pregnant women. This study aims to establish early pregnancy related thyroid hormones models and reference intervals for pregnant women. We established two derived databases: derived database* and derived database#. Reference individuals in database* were used to establish gestational age-specific reference intervals for thyroid hormones and early pregnancy related thyroid hormones models for pregnant women. Individuals in database# were apparently healthy non-pregnant women. The thyroid hormones levels of individuals in database# were compared with that of individuals in database* using nonparametric methods and the comparative confidence interval method. The differences in thyroid stimulating hormone and free thyroxine between early pregnant and non-pregnant women were statistically significant (p&lt;0.0001). The reference intervals of thyroid stimulating hormone, free thyroxine and free triiodothyronine for early pregnant women were 0.052\u20133.393\u2009\u03bcIU\/ml, 1.01\u20131.54\u2009ng\/dl, and 2.51\u20133.66\u2009pg\/ml, respectively. Results concerning thyroid stimulating hormone and free thyroxine reference intervals of early pregnancy are comparable with those from other studies using the same detection platform. Early pregnancy related thyroid hormones models showed various change patterns with gestational age for thyroid hormones. Early pregnancy related thyroid hormones models and reference intervals for pregnant women were established, so as to provide accurate and reliable reference basis for the diagnosing and monitoring of maternal thyroid disfunction in early pregnancy.<\/jats:p>","DOI":"10.1055\/a-1402-0290","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T22:32:09Z","timestamp":1618439529000},"page":"272-279","source":"Crossref","is-referenced-by-count":5,"title":["Establishment of Early Pregnancy Related Thyroid Hormone Models and Reference Intervals for Pregnant Women in China Based on Real World Data"],"prefix":"10.1055","volume":"53","author":[{"given":"Chaochao","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Basic Medicine Peking Union Medical College, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicong","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danchen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0734-8144","authenticated-orcid":false,"given":"Ling","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. 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Endocrinol Metab"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1515\/cclm-2014-0350","article-title":"Thyroid function and thyroid autoimmunity in apparently healthy pregnant and non-pregnant Mexican women","volume":"52","author":"F A Quinn","year":"2014","journal-title":"Clin Chem Lab Med"},{"key":"ref37","first-page":"74","article-title":"Reference intervals for thyroid markers in early pregnancy determined by 7 different analytical systems","author":"D Springer","year":"2014","journal-title":"Scand J Clin Lab Invest"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1089\/thy.2015.0613","article-title":"Iodine status and prevalence of thyroid disorders after introduction of mandatory universal salt iodization for 16 years in China: A cross-sectional study in 10 cities","volume":"26","author":"Z Shan","year":"2016","journal-title":"Thyroid"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1402-0290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T03:26:47Z","timestamp":1698895607000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1402-0290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":38,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2021,4,14]]},"published-print":{"date-parts":[[2021,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1402-0290","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}