{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:38:25Z","timestamp":1768322305529,"version":"3.49.0"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\nEinleitung Internationalen und nationalen Leitlinien fehlt es an detaillierten Empfehlungen zur Infektionsdiagnostik und -therapie bei drohender Fr\u00fchgeburt. Ziel der Studie war es, Daten zur Versorgungssituation an deutschen Perinatalzentren zu erheben.<\/jats:p><jats:p>\nMethoden Onlineumfrage zum Infektionsmanagement bei drohender Fr\u00fchgeburt an allen 212 deutschen Perinatalzentren der Versorgungsstufen Level I und II.<\/jats:p><jats:p>\nErgebnisse Die R\u00fccklaufquote betrug 31,6% (n=67). Bei drohender Fr\u00fchgeburt unter 34 vollendeten SSW ohne Blasensprung verzichten 78,8% auf eine kalkulierte Antibiotikagabe. Von den verbleibenden vierzehn Zentren (21,2%) w\u00fcrde die H\u00e4lfte generell bei klinischen Zeichen einer drohenden Fr\u00fchgeburt antibiotisch behandeln. Fast alle Zentren (94%) f\u00fchren eine vaginale Erregerdiagnostik durch. Eine mikroskopische Abstrichbeurteilung mittels Nugent- oder Amsel-Score erfolgt in 37,3%. Abweichungen von der physiologischen vaginalen Mikrobiota werden mehrheitlich antibiotisch behandelt (bakterielle Vaginose 79,1%, n=53, Candida spp. 77,6%, n=52, Ureaplasma spp. 49,3%, n=33). Kontrollabstriche erfolgen in 70,1%. Konsens besteht hinsichtlich einer Antibiotikagabe bei fr\u00fchem vorzeitigem Blasensprung. 72,6% bevorzugen eine Monotherapie mit einem \u03b2-Laktam-Antibiotikum. Uneinheitlich waren hier die Angaben zur Dauer der Therapie, wobei 58% der Zentren l\u00e4nger als sieben Tage behandeln.<\/jats:p><jats:p>\nSchlussfolgerung An deutschen Perinatalzentren besteht eine hohe Bereitschaft zur Infektionsdiagnostik und -therapie bei drohender Fr\u00fchgeburt. Das Infektionsmanagement ist jedoch uneinheitlich und partiell widerspr\u00fcchlich zu den vorliegenden Leitlinien. Es besteht ein Bedarf an qualitativ hochwertigen Studien zu diesem Thema.<\/jats:p>","DOI":"10.1055\/a-1402-1545","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T22:48:11Z","timestamp":1618008491000},"page":"484-492","source":"Crossref","is-referenced-by-count":1,"title":["Infektionsmanagement bei drohender Fr\u00fchgeburt \u2013 eine Umfrage an deutschen Perinatalzentren"],"prefix":"10.1055","volume":"225","author":[{"given":"Theresa","family":"Pech","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik, Medizinische Fakult\u00e4t der Universit\u00e4t Rostock, Rostock, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Gerber","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik, Medizinische Fakult\u00e4t der Universit\u00e4t Rostock, Rostock, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Stubert","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik, Medizinische Fakult\u00e4t der Universit\u00e4t Rostock, Rostock, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1046\/j.1365-3016.2001.00007.x","article-title":"The role of infection in preterm labour and delivery","volume":"15","author":"R Romero","year":"2001","journal-title":"Paediatr Perinat Epidemiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.siny.2011.09.001","article-title":"Intrauterine infection and preterm labor","volume":"17","author":"V Agrawal","year":"2012","journal-title":"Semin Fetal Neonatal Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine infection and preterm delivery","volume":"342","author":"R L Goldenberg","year":"2000","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/00006250-199203000-00005","article-title":"The association of occult amniotic fluid infection with gestational age and neonatal outcome among women in preterm labor","volume":"79","author":"D H Watts","year":"1992","journal-title":"Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0002-9378(84)90534-9","article-title":"Bacterial attachment to the chorioamniotic membranes","volume":"148","author":"R P Galask","year":"1984","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1067\/mob.2001.117680","article-title":"Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes","volume":"185","author":"B H Yoon","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e3056","DOI":"10.1371\/journal.pone.0003056","article-title":"Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation","volume":"3","author":"D B DiGiulio","year":"2008","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"627, e621","DOI":"10.1016\/j.ajog.2016.01.193","article-title":"The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis","volume":"214","author":"A L Prince","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1515\/jpm-2019-0297","article-title":"Evidence that intra-amniotic infections are often the result of an ascending invasion \u2013 a molecular microbiological study","volume":"47","author":"R Romero","year":"2019","journal-title":"J Perinat Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00006250-198602000-00013","article-title":"Preterm labor associated with subclinical amniotic fluid infection and with bacterial vaginosis","volume":"67","author":"M G Gravett","year":"1986","journal-title":"Obstet Gynecol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1136\/bmj.308.6924.295","article-title":"Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage","volume":"308","author":"P E Hay","year":"1994","journal-title":"BMJ"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1056\/NEJM199512283332604","article-title":"Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. 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