{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:03:46Z","timestamp":1780499026980,"version":"3.54.1"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2002To compare the diagnostic accuracy of transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) for detecting cervical infiltration by endometrial carcinoma using meta-analysis assessment.<\/jats:p><jats:p>\n          Methods\u2002An extensive search of papers comparing TVS and MRI for assessing cervical infiltration in endometrial cancer in the same set of patients was performed in Medline (Pubmed), Web of Science, and the Cochrane Database. Quality was assessed using QUADAS-2 tool (Quality Assessment of Diagnostic Accuracy Studies-2). Quantitative meta-analysis was performed.<\/jats:p><jats:p>\n          Results\u2002Our extended search identified 12 articles that used both techniques in the same set of patients and were included in the meta-analysis. The risk of bias for most studies was high for patient selection and index tests in QUADAS-2. Overall, the pooled estimated sensitivity and specificity for diagnosing cervical infiltration in women with endometrial cancer were identical for both techniques [69\u200a% (95\u200a%\u202fCI, 51\u200a%\u201382\u200a%) and 93\u200a% (95\u200a%\u202fCI, 90\u200a%\u201395\u200a%) for TVS, and 69\u200a% (95\u200a%\u202fCI, 57\u200a%\u201379\u200a%) and 91\u200a% (95\u200a%\u202fCI, 90\u200a%\u201395\u200a%) for MRI, respectively]. No statistical differences were found when comparing both methods. Heterogeneity was high for sensitivity and moderate for specificity when analyzing TVS and moderate for both sensitivity and specificity in the case of MRI.<\/jats:p><jats:p>\n          Conclusion\u2002TVS and MRI showed very similar diagnostic performance for diagnosing cervical involvement in women with endometrial cancer.<\/jats:p>","DOI":"10.1055\/a-1408-2292","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T23:52:06Z","timestamp":1616543526000},"page":"280-289","source":"Crossref","is-referenced-by-count":8,"title":["Preoperative Assessment of Cervical Involvement in Endometrial Cancer by Transvaginal Ultrasound and Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis"],"prefix":"10.1055","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9700-0853","authenticated-orcid":false,"given":"Juan Luis","family":"Alcazar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, University of Navarra Clinic, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Carazo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, University Hospital Complex Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyre","family":"Pegenaute","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Araba University Hospital Txagorritxu Campus, Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gurrea","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Virgen de la Arrixaca University Hospital, El Palmar, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Campos","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Virgen de la Arrixaca University Hospital, El Palmar, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Neri","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Universit\u00e0 degli Studi di Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-6981","authenticated-orcid":false,"given":"Maria Angela","family":"Pascual","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Institut Universitari Dexeus, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-7155","authenticated-orcid":false,"given":"Stefano","family":"Guerriero","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Universit\u00e0 degli Studi di Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/jnci\/djx214","article-title":"International patterns and trends in endometrial cancer incidence, 1978\u20132013","volume":"110","author":"J Lortet-Tieulent","year":"2018","journal-title":"J Natl Cancer Inst"},{"issue":"S 02","key":"ref2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ijgo.12612","article-title":"Cancer of the corpus uteri","volume":"143","author":"F Amant","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/IGC.0000000000000609","article-title":"ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-up","volume":"26","author":"N Colombo","year":"2016","journal-title":"Int J Gynecol 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Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/uog.15762","article-title":"Synthesizing Evidence from Diagnostic Accuracy TEsts: the SEDATE guideline","volume":"47","author":"A Sotiriadis","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"D Moher","year":"2009","journal-title":"BMJ"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"P F Whiting","year":"2011","journal-title":"Ann Intern Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"J PT Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jclinepi.2005.01.016","article-title":"The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed","volume":"58","author":"J J Deeks","year":"2005","journal-title":"J Clin Epidemiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1471-0528.1998.tb10151.x","article-title":"A comparative study of pre-operative procedures to assess cervical invasion by endometrial carcinoma","volume":"105","author":"T Toki","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/uog.5295","article-title":"Preoperative local staging of endometrial cancer: transvaginal sonography vs. magnetic resonance imaging","volume":"31","author":"L 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