{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:51:51Z","timestamp":1756385511529},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Einleitung\/Ziel\u2002Die Dermatomyositis (DM) ist eine seltene Erkrankung, die sich klinisch durch Schw\u00e4che und Schmerzen proximaler Muskeln sowie fliederfarbene Hautver\u00e4nderungen manifestiert. In fast einem F\u00fcnftel der F\u00e4lle ist die DM\u200amit dem Auftreten von Tumorerkrankungen assoziiert. Ziel dieser Untersuchung ist die Bewertung der Bedeutung der DM\u200aals paraneoplastisches Syndrom bei Malignomen im Kopf-Hals-Bereich unter Ber\u00fccksichtigung der aktuellen Literatur.<\/jats:p><jats:p>Material\/Methoden\u2002Nach retrospektiver Krankenaktenanalyse der Jahre 2008\u20132018 von Patienten mit Kopf-Hals-Malignomen fanden sich 8 Patienten mit einer Dermatomyositis: 4 Patienten mit Tonsillenkarzinom, 1 Patient mit Nasopharynxkarzinom, 1 Patient mit Parotiskarzinom und 2 Patienten mit Lymphomen. Es wurden die Diagnostik, Therapie und Behandlungsergebnisse der F\u00e4lle beschrieben. Zudem erfolgte eine selektive Analyse der Literatur (PubMed) zur DM\u200abei HNO-Tumoren. Bei dieser fanden sich insgesamt 290 F\u00e4lle: Die Malignome waren in 283 F\u00e4llen im Nasopharynx, in 5 F\u00e4llen in der Tonsille und in 2\u00a0F\u00e4llen im Hypopharynx lokalisiert.<\/jats:p><jats:p>Ergebnisse\/Schlussfolgerung\u2002Eine DM\u200aals paraneoplastisches Syndrom bei Kopf-Hals-Malignomen ist selten. Sie tritt h\u00e4ufiger in Assoziation mit Nasopharynxkarzinomen und selten bei Tonsillenkarzinomen auf.<\/jats:p><jats:p>Das geh\u00e4ufte Auftreten der DM\u200abei Kopf-Hals-Malignomen in Abh\u00e4ngigkeit von der ethnischen Verteilung (Nasopharynxkarzinome \u2013 asiatische Abstammung, Tonsillenkarzinom \u2013 kaukasische Abstammung) ist m\u00f6glicherweise auch auf regionale Inzidenzunterschiede der genannten Tumorentit\u00e4ten zur\u00fcckzuf\u00fchren.<\/jats:p><jats:p>Bei Patienten mit einer DM\u200asollte ein Tumorausschluss auch im Kopf-Hals-Bereich erfolgen, insbesondere bei Vorliegen einer zervikalen Lymphadenopathie. Der Verlauf einer tumorassoziierten DM\u200awird durch die Tumortherapie positiv beeinflusst. Therapeutisch ist aber auch eine konsequente Behandlung der DM\u200adie Grundlage f\u00fcr eine erfolgreiche Tumortherapie.<\/jats:p>","DOI":"10.1055\/a-1408-6551","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T22:48:48Z","timestamp":1619563728000},"page":"542-549","source":"Crossref","is-referenced-by-count":1,"title":["Dermatomyositis als paraneoplastisches Syndrom bei Kopf-Hals-Malignomen: Fallserie &amp; Literaturreview"],"prefix":"10.1055","volume":"100","author":[{"given":"Jana","family":"Klukas","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Campus Benjamin Franklin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annett","family":"Pudszuhn","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Campus Benjamin Franklin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Kusch","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Dermatologie, Venerologie und Allergologie, Campus Benjamin Franklin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Obermueller","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Campus Benjamin Franklin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veit M.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Campus Benjamin Franklin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1007\/s10067-016-3296-8","article-title":"Malignancy in dermatomyositis and polymyositis: analysis of 192 patients","volume":"35","author":"Y F Fang","year":"2016","journal-title":"Clin Rheumatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e94128","DOI":"10.1371\/journal.pone.0094128","article-title":"Factors predicting malignancy in patients with polymyositis and dermatomyostis: a systematic review and meta-analysis","volume":"9","author":"X Lu","year":"2014","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.47102\/annals-acadmedsg.V39N11p843","article-title":"An 11-year review of dermatomyositis in Asian patients","volume":"39","author":"W C Liu","year":"2010","journal-title":"Ann Acad Med Singapore"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1177\/014107688307600916","article-title":"Dermatomyositis and salivary pleomorphic adenoma","volume":"76","author":"C A Holden","year":"1983","journal-title":"J R Soc Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/oxfordjournals.jjco.a023206","article-title":"Retropharyngeal abscess after radiation therapy and cis-platinum, 5-fluorouracil treatment for nasopharyngeal carcinoma with collagen disease: report of two patients and a review of the literature","volume":"26","author":"M Hareyama","year":"1996","journal-title":"Jpn J Clin Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1046\/j.1365-4362.1998.00453.x","article-title":"Amyopathic dermatomyositis in Hong Kong \u2013 association with nasopharyngeal carcinoma","volume":"37","author":"W K Fung","year":"1998","journal-title":"Int J Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1346-8138.1998.tb02451.x","article-title":"Dermatomyositis and nasopharyngeal carcinoma","volume":"25","author":"Z Abraham","year":"1998","journal-title":"J Dermatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00001813-200203000-00015","article-title":"Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review","volume":"13","author":"J Vardy","year":"2002","journal-title":"Anticancer Drugs"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00296-003-0319-y","article-title":"Dermatomyositis and malignancy of the pharynx in Caucasian patients: report of two observations","volume":"23","author":"C Botsios","year":"2003","journal-title":"Rheumatol Int"},{"key":"ref11","first-page":"399","article-title":"Urticarial vasculitis and dermatomyositis in a patient with nasopharyngeal carcinoma","volume":"72","author":"C C Wang","year":"2003","journal-title":"Cutis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.anorl.2010.10.007","article-title":"Paraneoplastic dermatomyositis accompanying nasopharyngeal carcinoma: diagnosis, treatment and prognosis","volume":"128","author":"A Chakroun","year":"2011","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.4103\/0378-6323.129408","article-title":"Dermatomyositis and nasopharyngeal carcinoma in an Indian patient","volume":"80","author":"V Gupta","year":"2014","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.11604\/pamj.2016.24.29.4822","article-title":"[Paraneoplastic dermatomyositis revealing an undifferentiated nasopharyngeal carcinoma: about a case]","volume":"24","author":"F Z Ziani","year":"2016","journal-title":"Pan Afr Med J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0360-3016(89)90102-8","article-title":"A clinical study of 407 cases of nasopharyngeal carcinoma in Hong Kong","volume":"17","author":"P Teo","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1001\/archotol.1995.01890110072013","article-title":"Nasopharyngeal carcinoma with dermatomyositis. Analysis of 12 cases","volume":"121","author":"J C Peng","year":"1995","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00000421-199602000-00008","article-title":"Study of 45 cases of nasopharyngeal carcinoma with dermatomyositis","volume":"19","author":"W J Hu","year":"1996","journal-title":"Am J Clin Oncol"},{"key":"ref18","first-page":"401","article-title":"[Nasopharyngeal carcinoma and dermatomyositis (analysis of 12 cases)]","volume":"12","author":"X Song","year":"1998","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1001\/archderm.142.1.112","article-title":"Dermatomyositis and nasopharyngeal carcinoma: report of 8 cases","volume":"142","author":"H Boussen","year":"2006","journal-title":"Arch Dermatol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"R70","DOI":"10.1186\/ar2987","article-title":"Cancer risks of dermatomyositis and polymyositis: a nationwide cohort study in Taiwan","volume":"12","author":"Y J Chen","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3109\/00016489.2014.913312","article-title":"Paired study of 172 cases of nasopharyngeal carcinoma with or without dermatomyositis","volume":"134","author":"P Y Huang","year":"2014","journal-title":"Acta Otolaryngol"},{"key":"ref22","first-page":"77","article-title":"Dermatomyositis and malignancy: a retrospective study of 115 cases","volume":"13","author":"W Zhang","year":"2009","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref23","first-page":"340","article-title":"[Dermatomyositis\/polymyositis associated with head and neck malignancy]","volume":"19","author":"W Liu","year":"2005","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"key":"ref24","first-page":"89","article-title":"Inflammatory myopathies \u2013 a review of newly diagnosed patients (2004\u20132008) in the Counties Manukau region","volume":"126","author":"R Gupta","year":"2013","journal-title":"N Z Med J"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1111\/j.1365-4632.2011.05449.x","article-title":"A comparative study of clinical characteristics, work-up, treatment, and association to malignancy in dermatomyositis between two tertiary skin centers in the USA and Singapore","volume":"52","author":"G Yosipovitch","year":"2013","journal-title":"Int J Dermatol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e0181069","DOI":"10.1371\/journal.pone.0181069","article-title":"An efficacy analysis of whole-body magnetic resonance imaging in the diagnosis and follow-up of polymyositis and dermatomyositis","volume":"12","author":"Z G Huang","year":"2017","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3349\/ymj.2010.51.4.605","article-title":"Tonsillar squamous cell carcinoma associated with dermatomyositis: the first 2 cases in Korea","volume":"51","author":"S W Kim","year":"2010","journal-title":"Yonsei Med J"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s00106-013-2682-7","article-title":"[Dermatomyositis with tonsillar carcinoma. Rare presentation as paraneoplastic syndrome]","volume":"62","author":"E Scholz","year":"2014","journal-title":"HNO"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1002\/hed.23703","article-title":"Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: a case report","volume":"37","author":"A H Adi","year":"2015","journal-title":"Head Neck"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0248-8663(00)00331-3","article-title":"[Macro-CK disclosing disseminated epidermoid carcinoma of the pyriform sinus in a patient with dermatomyositis]","volume":"22","author":"S Bonnet","year":"2001","journal-title":"Rev Med Interne"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.rpor.2014.02.005","article-title":"Nasopharyngeal carcinoma in dermatomyositis patients: A 10-year retrospective review in Hospital Selayang, Malaysia","volume":"19","author":"J W Teoh","year":"2014","journal-title":"Rep Pract Oncol Radiother"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jcv.2010.08.015","article-title":"Polymyositis\/dermatomyositis and nasopharyngeal carcinoma: the Epstein-Barr virus connection?","volume":"49","author":"D Y Chen","year":"2010","journal-title":"J Clin Virol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1097\/01.rlu.0000257282.76269.85","article-title":"F-18 FDG PET\/CT detection of mediastinal malignancy in a patient with dermatomyositis","volume":"32","author":"N Liau","year":"2007","journal-title":"Clin Nucl Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s40880-017-0257-9","article-title":"Nasopharyngeal carcinoma incidence and mortality in China, 2013","volume":"36","author":"K R Wei","year":"2017","journal-title":"Chin J Cancer"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"114","DOI":"10.5732\/cjc.010.10377","article-title":"The prevalence and prevention of nasopharyngeal carcinoma in China","volume":"30","author":"S M Cao","year":"2011","journal-title":"Chin J Cancer"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0306-9877(93)90033-M","article-title":"Dermatomyositis\/polymyositis associated with internal malignancy: a consequence of how neoplasms alter generalized extracellular matrix in the host","volume":"41","author":"O J Stone","year":"1993","journal-title":"Med Hypotheses"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"437231","DOI":"10.1155\/2014\/437231","article-title":"A Potential Link between Environmental Triggers and Autoimmunity","volume":"2014","author":"A Vojdani","year":"2014","journal-title":"Autoimmune Dis"}],"container-title":["Laryngo-Rhino-Otologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1408-6551.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T21:18:30Z","timestamp":1698959910000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1408-6551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,27]]},"references-count":36,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2021,6,23]]},"published-print":{"date-parts":[[2021,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1408-6551","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0935-8943","1438-8685"],"issn-type":[{"value":"0935-8943","type":"print"},{"value":"1438-8685","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,27]]}}}