{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:14Z","timestamp":1787004854570,"version":"build-2736575974"},"reference-count":92,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The use of Cannabis sativa is currently recognized to ease certain types of chronic pain, reduce chemotherapy-induced nausea, and improve anxiety. Nevertheless, few studies highlighted the therapeutic potential of C. sativa extracts and related phytocannabinoids for a variety of widespread skin disorders including acne, atopic dermatitis, psoriasis, pruritus, and pain. This review summarized the current evidence on the effects of phytocannabinoids at the cutaneous level through the collection of in vitro, in vivo, and clinical studies published on PubMed, Scopus, Embase, and Web of Science until October 2020. Phytocannabinoids have demonstrated potential anti-inflammatory, antioxidant, anti-aging, and anti-acne properties by various mechanisms involving either CB1\/2-dependent and independent pathways. Not only classical immune cells, but also several skin-specific actors, such as keratinocytes, fibroblasts, melanocytes, and\n\t\t\t\t\tsebocytes, may represent a target for phytocannabinoids. Cannabidiol, the most investigated compound, revealed photoprotective, antioxidant, and anti-inflammatory mechanisms at the cutaneous level, while the possible impact on cell differentiation, especially in the case of psoriasis, would require further investigation. Animal models and pilot clinical studies supported the application of cannabidiol in inflammatory-based skin diseases. Also, one of the most promising applications of non-psychotropic phytocannabinoids is the treatment of seborrheic disorders, especially acne. In conclusion, the incomplete knowledge of the role of the endocannabinoid system in skin disorders emerged as an important limit for pharmacological investigations. Moreover, the limited studies conducted on C.\u00a0sativa extracts suggested a higher potency than single phytocannabinoids, thus stimulating new research on phytocannabinoid interaction.<\/jats:p>","DOI":"10.1055\/a-1420-5780","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T21:00:52Z","timestamp":1618347652000},"page":"492-506","source":"Crossref","is-referenced-by-count":47,"title":["Cannabis sativa and Skin Health: Dissecting the Role of Phytocannabinoids"],"prefix":"10.1055","volume":"88","author":[{"given":"Giulia","family":"Martinelli","sequence":"first","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences (DiSFeB), Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Magnavacca","sequence":"first","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences (DiSFeB), Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences (DiSFeB), Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Dell\u02bcAgli","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences (DiSFeB), Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Piazza","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences (DiSFeB), Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Sangiovanni","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences (DiSFeB), Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12229-015-9157-3","article-title":"Evolution and classification of Cannabis sativa (Marijuana, Hemp) in relation to human utilization","volume":"81","author":"E Small","year":"2015","journal-title":"Bot Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jep.2018.09.004","article-title":"Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history","volume":"227","author":"S A Bonini","year":"2018","journal-title":"J Ethnopharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/medicines6010031","article-title":"Cannabis and its secondary metabolites: their use as therapeutic drugs, toxicological aspects, and analytical determination","volume":"6","author":"J Goncalves","year":"2019","journal-title":"Medicines (Basel)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1001\/jamadermatol.2015.6120","article-title":"Cannabis and Dr. Piffard\u2013a century ahead of the curve","volume":"152","author":"Z Theroux","year":"2016","journal-title":"JAMA Dermatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3390\/molecules24050918","article-title":"Cannabinoid signaling in the skin: therapeutic potential of the \u201cc(ut)annabinoid\u201d system","volume":"24","author":"K F Toth","year":"2019","journal-title":"Molecules"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1177\/1203475417738971","article-title":"The risks and benefits of cannabis in the dermatology clinic","volume":"22","author":"G Dhadwal","year":"2018","journal-title":"J Cutan Med Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1080\/09546634.2019.1675854","article-title":"The potential role of cannabinoids in dermatology","volume":"31","author":"T Sheriff","year":"2020","journal-title":"J Dermatolog Treat"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bcp.2018.08.022","article-title":"The endocannabinoid system of the skin. 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Generation of a peroxisome proliferator-activated receptor alpha agonist","volume":"277","author":"K R Kozak","year":"2002","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"13895","DOI":"10.1074\/jbc.M114.605998","article-title":"Fatty Acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor \u03b1 in a ligand-selective manner","volume":"290","author":"M L Hughes","year":"2015","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1074\/jbc.M114.618447","article-title":"Fatty acid-binding proteins (FABPs) are intracellular carriers for delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD)","volume":"290","author":"M W Elmes","year":"2015","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/cddis.2013.141","article-title":"Involvement of PPAR gamma in the antitumoral action of 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inflammation","volume":"204","author":"L De Petrocellis","year":"2012","journal-title":"Acta Physiol (Oxf)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000201556","article-title":"The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function","volume":"83","author":"J Ahrens","year":"2009","journal-title":"Pharmacology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1084\/jem.20120242","article-title":"Cannabinoids suppress inflammatory and neuropathic pain by targeting \u03b13 glycine receptors","volume":"209","author":"W Xiong","year":"2012","journal-title":"J Exp Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1046\/j.1523-1747.2003.12367.x","article-title":"Influx of calcium and chloride ions into epidermal keratinocytes regulates exocytosis of epidermal lamellar bodies and skin permeability barrier homeostasis","volume":"121","author":"M Denda","year":"2003","journal-title":"J Invest Dermatol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/exd.12651","article-title":"Functional glycine receptor in cultured human keratinocytes","volume":"24","author":"K Inoue","year":"2015","journal-title":"Exp Dermatol"},{"key":"ref24","first-page":"1","article-title":"Phytochemistry of Cannabis sativa L","volume":"103","author":"M A ElSohly","year":"2017","journal-title":"Prog Chem Org Nat Prod"},{"key":"ref25","first-page":"61","article-title":"Molecular pharmacology of phytocannabinoids","volume":"103","author":"S E Turner","year":"2017","journal-title":"Prog Chem Org Nat Prod"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1039\/C6NP00074F","article-title":"Phytocannabinoids: a unified critical inventory","volume":"33","author":"L O Hanus","year":"2016","journal-title":"Nat Prod Rep"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.3390\/ijms21093067","article-title":"Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: Useful nutraceuticals?","volume":"21","author":"V Mart\u00ednez","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref28","first-page":"3","volume-title":"Constituents of Cannabis sativa","author":"M Elsohly","year":"2014"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tips.2009.07.006","article-title":"Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb","volume":"30","author":"A A Izzo","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-2999(02)02624-9","article-title":"(\u2212)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas 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cannabidiol and \u0394(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? 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Whyte","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/sj.bjp.0707460","article-title":"The orphan receptor GPR55 is a novel cannabinoid receptor","volume":"152","author":"E Ryberg","year":"2007","journal-title":"Br J Pharmacol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1111\/j.1476-5381.2011.01497.x","article-title":"\u0394(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells","volume":"165","author":"D McHugh","year":"2012","journal-title":"Br J Pharmacol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1177\/1074248414532013","article-title":"The effect of cannabidiol on ischemia\/reperfusion-induced ventricular arrhythmias: the role of adenosine A1 receptors","volume":"20","author":"E Gonca","year":"2015","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.1073\/pnas.0511232103","article-title":"Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression","volume":"103","author":"E J Carrier","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1084\/jem.20120242","article-title":"Cannabinoids suppress inflammatory and neuropathic pain by targeting alpha3 glycine receptors","volume":"209","author":"W Xiong","year":"2012","journal-title":"J Exp Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s11064-005-6978-1","article-title":"Agonistic properties of cannabidiol at 5-HT1a receptors","volume":"30","author":"E B Russo","year":"2005","journal-title":"Neurochem Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1124\/jpet.109.162594","article-title":"The\u00a0nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in Xenopus laevis oocytes","volume":"333","author":"K H Yang","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/sj.bjp.0704327","article-title":"Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide","volume":"134","author":"T Bisogno","year":"2001","journal-title":"Br J Pharmacol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1021\/cn5000524","article-title":"Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability","volume":"5","author":"F A Iannotti","year":"2014","journal-title":"ACS Chem Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1124\/jpet.107.134809","article-title":"Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8","volume":"325","author":"L De Petrocellis","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1476-5381.2010.01063.x","article-title":"Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action","volume":"162","author":"S Maione","year":"2011","journal-title":"Br J Pharmacol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00210-006-0033-x","article-title":"Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors","volume":"372","author":"M Kathmann","year":"2006","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.lfs.2005.09.011","article-title":"Chemical constituents of marijuana: the complex mixture of natural cannabinoids","volume":"78","author":"M A Elsohly","year":"2005","journal-title":"Life Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1021\/np070454a","article-title":"Cannabinoid ester constituents from high-potency Cannabis sativa","volume":"71","author":"S A Ahmed","year":"2008","journal-title":"J Nat Prod"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1055\/s-2008-1034311","article-title":"Isolation and characterization of new Cannabis constituents from a high potency variety","volume":"74","author":"M M Radwan","year":"2008","journal-title":"Planta Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1021\/np900067k","article-title":"Biologically active cannabinoids from high-potency Cannabis sativa","volume":"72","author":"M M Radwan","year":"2009","journal-title":"J Nat Prod"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3389\/fphar.2018.00632","article-title":"Cannabigerol action at cannabinoid CB1 and CB2 receptors and at CB1\u2013CB2 heteroreceptor complexes","volume":"9","author":"G Navarro","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/j.1476-5381.2010.01166.x","article-title":"Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes","volume":"163","author":"L De Petrocellis","year":"2011","journal-title":"Br J Pharmacol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1476-5381.2009.00515.x","article-title":"Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist","volume":"159","author":"M G Cascio","year":"2010","journal-title":"Br J Pharmacol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1039\/c19660000020","article-title":"Cannabichromene, a new active principle in hashish","author":"Y Gaoni","year":"1966","journal-title":"Chemical Communications (London)"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1111\/bph.14815","article-title":"Cannabichromene is a cannabinoid CB2 receptor agonist","volume":"176","author":"M Udoh","year":"2019","journal-title":"Br J Pharmacol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"110889","DOI":"10.1016\/j.biopha.2020.110889","article-title":"Plant-derived natural 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Atalay","year":"2020","journal-title":"Redox Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3390\/cells8080827","article-title":"Cannabidiol regulates the expression of keratinocyte proteins involved in the inflammation process through transcriptional regulation","volume":"8","author":"A Jastrzab","year":"2019","journal-title":"Cells"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1002\/ptr.6400","article-title":"Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury","volume":"33","author":"E Sangiovanni","year":"2019","journal-title":"Phytother Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"101321","DOI":"10.1016\/j.redox.2019.101321","article-title":"Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1","volume":"28","author":"L Casares","year":"2020","journal-title":"Redox Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"862391","DOI":"10.1155\/2015\/862391","article-title":"Flax Fiber hydrophobic extract inhibits human skin cells inflammation and causes remodeling of extracellular matrix and wound closure activation","volume":"2015","author":"M Styrczewska","year":"2015","journal-title":"Biomed Res Int"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3390\/cells8090995","article-title":"The differences in the proteome profile of cannabidiol-treated skin fibroblasts following UVA or UVB irradiation in 2D and 3D cell cultures","volume":"8","author":"A Gegotek","year":"2019","journal-title":"Cells"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cbi.2017.06.005","article-title":"Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42\/44 MAPK","volume":"273","author":"Y S Hwang","year":"2017","journal-title":"Chem Biol 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vitro\/in vivo correlation studies for transdermal delta 8-THC development","volume":"93","author":"S Valiveti","year":"2004","journal-title":"J Pharm Sci"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1211\/0022357022791","article-title":"Human skin permeation of Delta8-tetrahydrocannabinol, cannabidiol and cannabinol","volume":"56","author":"A L Stinchcomb","year":"2004","journal-title":"J Pharm Pharmacol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/all.12183","article-title":"Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors","volume":"68","author":"E Gaffal","year":"2013","journal-title":"Allergy"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.lfs.2015.04.003","article-title":"Differential role of cannabinoids in the pathogenesis of skin cancer","volume":"138","author":"N Glodde","year":"2015","journal-title":"Life Sci"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.npep.2011.03.005","article-title":"Inhibitory CB1 and activating\/desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin","volume":"45","author":"M A Engel","year":"2011","journal-title":"Neuropeptides"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/bph.12309","article-title":"Epigenetic control of skin differentiation genes by phytocannabinoids","volume":"170","author":"M Pucci","year":"2013","journal-title":"Br J Pharmacol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jdermsci.2006.10.009","article-title":"Cannabinoids inhibit human keratinocyte proliferation through a non-CB1\/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis","volume":"45","author":"J D Wilkinson","year":"2007","journal-title":"J Dermatol Sci"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1124\/jpet.117.244368","article-title":"Anti-inflammatory properties of cannabidiol, a nonpsychotropic cannabinoid, in experimental allergic contact dermatitis","volume":"365","author":"S Petrosino","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3390\/ijms17081234","article-title":"Molecular mechanisms of cutaneous inflammatory disorder: atopic dermatitis","volume":"17","author":"J E Kim","year":"2016","journal-title":"Int J Mol Sci"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.0022-202X.2004.23426.x","article-title":"Loss of keratin 10 leads to mitogen-activated protein kinase (MAPK) activation, increased keratinocyte turnover, and decreased tumor formation in mice","volume":"123","author":"J Reichelt","year":"2004","journal-title":"J Invest Dermatol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF00915771","article-title":"Analgesic and antiinflammatory activity of constituents of Cannabis sativa L","volume":"12","author":"E A Formukong","year":"1988","journal-title":"Inflammation"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.fitote.2010.04.009","article-title":"Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins","volume":"81","author":"A Tubaro","year":"2010","journal-title":"Fitoterapia"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jconrel.2003.09.001","article-title":"Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model","volume":"93","author":"M Lodzki","year":"2003","journal-title":"J Control Release"},{"key":"ref85","first-page":"178","article-title":"Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs","volume":"82","author":"L R Bartner","year":"2018","journal-title":"Can J Vet Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"e224-e227","DOI":"10.1111\/pde.13545","article-title":"Self-initiated use of topical cannabidiol oil for epidermolysis bullosa","volume":"35","author":"M P Chelliah","year":"2018","journal-title":"Pediatr Dermatol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/bjd.17341","article-title":"Combined tetrahydrocannabinol and cannabidiol to treat pain in epidermolysis bullosa: a report of three cases","volume":"180","author":"N HB Schrader","year":"2019","journal-title":"Br J Dermatol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1016\/j.jid.2018.03.1074","article-title":"1061 The safety of topical cannabidiol (CBD) for the treatment of acne","volume":"138","author":"L Spleman","year":"2018","journal-title":"J Invest 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