{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T20:01:42Z","timestamp":1748289702493},"reference-count":90,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hyperandrogenism in polycystic ovary syndrome (PCOS) is associated with\nthe risk for the future development of the cardiovascular disease. The\nobjective of the study is to verify whether different androgens have the\nsame harmful effect. This cross-sectional study enrolled 823 women with\nPCOS: 627 (76.2%) with biochemical hyperandrogenism and 196\n(23.8%) with normal androgen levels. The role of individual androgen\nwas evaluated using univariate and multivariate logistic regression. In\nnormoandrogenemic PCOS (NA-PCOS), free androgen index (FAI) predicted\nsignificant abnormality in visceral adipose index (VAI, OR=9.2,\np=0.002) and dehydroepiandrosterone (DHEA) predicted against\nalteration in \u03b2-cell function (OR=0.5, p=0.007). In\nhyperandrogenemic PCOS (HA-PCOS), FAI predicted derangements in waist\ntriglyceride index (WTI), VAI, and lipid accumulation product (LAP) (OR\nranging from 1.6 to 5.8, p&lt;0.05). DHEA weakly predicted against VAI\n(OR 0.7, p=0.018), dehydroepiandrosterone sulfate (DHEAS) tended to\npredict against the conicity index (OR=0.7, p=0.037). After\nmultiple regression, FAI retained significant strength to predict various\nanthropometric and metabolic abnormalities (OR ranging from 1.1 to 3.0,\np&lt;0.01), DHEA was kept as a protector factor against WTI, LAP, and\nVAI (OR ranging from 0.6 to 0.9; p&lt;0.01) and DHEAS against the\nconicity index (OR=0.5, p&lt;0.001). In conclusion, the free\nandrogen index was the most powerful predictor of anthropometric and\nmetabolic abnormalities of polycystic ovary syndrome. Conversely, DHEA and\nDHEAS demonstrated protective effects against disorders in some markers of\nobesity and abnormal metabolism.<\/jats:p>","DOI":"10.1055\/a-1422-3243","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T23:29:56Z","timestamp":1618961396000},"page":"341-349","source":"Crossref","is-referenced-by-count":5,"title":["Differential Effects of Various Androgens on Polycystic Ovary Syndrome"],"prefix":"10.1055","volume":"53","author":[{"given":"Sebasti\u00e3o Freitas","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Medical School, Federal\nUniversity of Mato Grosso, Cuiab\u00e1, MT, Brazil"},{"name":"Tropical Institute of Reproductive Medicine, Cuiab\u00e1, MT,\nBrazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Barcelo","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Tropical Institute of Reproductive Medicine, Cuiab\u00e1, MT,\nBrazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Karine Lin Winck Yamamoto","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Tropical Institute of Reproductive Medicine, Cuiab\u00e1, MT,\nBrazil"},{"name":"University of Cuiab\u00e1, MT, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Ant\u00f4nio Souto","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Tropical Institute of Reproductive Medicine, Cuiab\u00e1, MT,\nBrazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia Marly Winck","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Tropical Institute of Reproductive Medicine, Cuiab\u00e1, MT,\nBrazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1210\/jc.2003-031122","article-title":"Androgen excess in women: experience with over 1000 consecutive patients","volume":"89","author":"R Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under\ncontrasting diagnostic criteria","volume":"25","author":"W A March","year":"2010","journal-title":"Hum Reprod"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on women's health aspects of polycystic ovary syndrome (PCOS):\nThe Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop\nGroup","volume":"97","author":"B C Fauser","year":"2012","journal-title":"Fertil Steril"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Androgen Excess Society. 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