{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:32:49Z","timestamp":1740126769720,"version":"3.37.3"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n               Einleitung Bei symptomatischen Mastoidh\u00f6hlen nach Ohroperationen besteht die Therapie der Wahl in der chirurgischen Verkleinerung. Hierbei stehen verschiedene Methoden und Materialien zur Obliteration zur Verf\u00fcgung. Allogenes Material ist leicht verf\u00fcgbar, kann jedoch zu Wundinfektionen aufgrund von Absto\u00dfungsreaktionen, Granulationen und Entz\u00fcndungsreaktionen f\u00fchren, weshalb autologes Material aufgrund seiner guten Biokompatibilit\u00e4t h\u00e4ufig bevorzugt wird. Ziel dieser Studie war es, die Langzeitergebnisse von Patienten nach Mastoidh\u00f6hlenobliteration mit allogenem und autologem Material im Hinblick auf das Auftreten von Rezidivcholesteatomen, die Anzahl der Revisionsoperationen und den Einfluss der Operation auf die Lebensqualit\u00e4t zu vergleichen.<\/jats:p><jats:p>\n               Methoden Patienten, die sich einer Mastoidh\u00f6hlenobliteration mit dem allogenen Material Hydroxylapatit-Matrix (HMM) unterzogen, wurden retrospektiv in die Studie eingeschlossen. In einem prospektiven Studienteil wurden Patienten eingeschlossen, welche sich einer Mastoidh\u00f6hlenobliteration mit autologem Rekonstruktionsmaterial (AutoM) unterzogen. Bei allen Patienten wurde neben einer ausf\u00fchrlichen Aktenanalyse eine Reintonaudiometrie durchgef\u00fchrt und bei der postoperativen Untersuchung das Z\u00fcrcher Mittelohrinventar (Zurich Chronic Middle Ear Inventory [ZCMEI-21]) zur Erhebung der gesundheitsbezogenen, krankheitsspezifischen Lebensqualit\u00e4t ausgef\u00fcllt.<\/jats:p><jats:p>\n               Ergebnisse Insgesamt wurden 22 Patienten mit einem durchschnittlichen Alter von 56,9 Jahren (SD 18,7 Jahre) und HMM (mittleres Nachuntersuchungsintervall: 88,3 Monate; SD 21,9 Monate) sowie 25 Patienten mit einem Durchschnittsalter von 52,4 Jahren (SD 13,7 Jahre) und AutoM (mittleres Nachuntersuchungsintervall: 13,5 Monate; SD 9,5 Monate) in die Studie eingeschlossen. Die audiologische Revisionsfreiheit lag nach einem Jahr f\u00fcr HMM bei 100% und f\u00fcr AutoM bei 85%. Die Rezidivfreiheit lag nach einem Jahr f\u00fcr HMM bei 95% und f\u00fcr AutoM bei 100%. Die Gruppen unterschieden sich weder hinsichtlich des postoperativen H\u00f6rergebnisses noch der postoperativen Lebensqualit\u00e4t.<\/jats:p><jats:p>\n               Diskussion Die Obliteration von Mastoidh\u00f6hlen ist eine chirurgische Herausforderung. Es zeigte sich kein relevanter Unterschied zwischen den verwendeten Materialien im Hinblick auf die Rezidivrate, das H\u00f6ren und die Lebensqualit\u00e4t \u00fcber den f\u00fcr beide Gruppen beobachteten Zeitraum von 13,5 Monaten. Die oft fehlende subjektive Symptomatik zusammen mit der hohen Rate an Rezidivcholesteatomen und Revisionsindikationen unterstreicht die Notwendigkeit einer regelm\u00e4\u00dfigen klinischen Nachsorge inklusive der Ohrmikroskopie bei chronischen Mittelohrerkrankungen und l\u00e4sst regelm\u00e4\u00dfige Nachuntersuchungen dringend empfehlen.<\/jats:p>","DOI":"10.1055\/a-1432-3123","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T22:46:34Z","timestamp":1620168394000},"page":"40-44","source":"Crossref","is-referenced-by-count":1,"title":["Allogenes und autologes Material f\u00fchrt bei Mastoidh\u00f6hlenobliteration zu vergleichbaren Rezidivraten"],"prefix":"10.1055","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-3591","authenticated-orcid":false,"given":"Nora","family":"Weiss","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie \u201eOtto K\u00f6rner\u201c, 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