{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T19:29:02Z","timestamp":1672860542818},"reference-count":7,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Zusammenfassung\u2002Procalcitonin (PCT) ist ein etablierter Marker f\u00fcr bakterielle Infektionen. Erh\u00f6hungen des PCT k\u00f6nnen jedoch aufgrund vielf\u00e4ltiger Ursachen auftreten und sind nicht spezifisch, wie wir in dem vorliegenden Fall kurz skizzieren m\u00f6chten.<\/jats:p><jats:p>\n          Anamnese\u2002Wir berichten \u00fcber eine 29-j\u00e4hrige Patientin, die bei unklaren abdominellen Schmerzen sowie seit 2 Tagen bestehender \u00dcbelkeit und Erbrechen von der psychiatrischen Klinik vorgestellt wurde. Die Anamnese war zun\u00e4chst nicht zielf\u00fchrend.<\/jats:p><jats:p>\n          Untersuchung und Diagnose\u2002Klinisch ergaben sich keine wegweisenden Befunde. Die Patientin war afebril. Laborchemisch zeigten sich deutlich erh\u00f6hte Transaminasen sowie ein massiv erh\u00f6htes PCT. Sonografisch stellten sich keine Auff\u00e4lligkeiten dar, die Hepatitis-Serologie fiel negativ aus. Entnommene Blutkulturen blieben steril, die weitere Infektfokussuche war blande.<\/jats:p><jats:p>\n          Therapie und Verlauf\u2002Im Verlauf des station\u00e4ren Aufenthalts berichtete die Patientin, 2 Tage zuvor kumulativ ca. 40\u200ag Paracetamol in suizidaler Absicht eingenommen zu haben. Eine Therapie mit N-Acetylcystein (NAC) wurde eingeleitet. Die Transaminasen und das PCT zeigten sich in den Folgetagen fallend. Auf eine antibiotische Therapie wurde verzichtet.<\/jats:p><jats:p>\n          Folgerung\u2002Der Fall zeigt, dass eine PCT-Erh\u00f6hung keinesfalls spezifisch f\u00fcr bakterielle Infektionen ist und der Laborwert immer in Korrelation mit der Anamnese und Klinik betrachtet werden muss.<\/jats:p>","DOI":"10.1055\/a-1442-5519","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T08:19:29Z","timestamp":1627546769000},"page":"818-820","source":"Crossref","is-referenced-by-count":1,"title":["Ungew\u00f6hnliche Ursache einer PCT-Erh\u00f6hung"],"prefix":"10.1055","volume":"146","author":[{"given":"Laura Clarissa","family":"Vogelbacher","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Thimme","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"179313","DOI":"10.1155\/2014\/179313","article-title":"Extreme Procalcitonin Elevation without Proven Bacterial Infection Related to Amphetamine Abuse","volume":"2014","author":"A Lovas","year":"2014","journal-title":"Case reports in critical care"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1136\/jclinpath-2014-202807","article-title":"Procalcitonin","volume":"68","author":"J Davies","year":"2015","journal-title":"Journal of Clinical Pathology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1097\/CCM.0B013E318165BABB","article-title":"Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations","volume":"36","author":"K L Becker","year":"2008","journal-title":"Critical Care Medicine"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e18882","DOI":"10.1097\/MD.0000000000018882","article-title":"Elevated procalcitonin levels in patients with acetaminophen intoxication: two case reports: A CARE-compliant article","volume":"99","author":"J H Ahn","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"631","DOI":"10.5604\/01.3001.0012.0932","article-title":"Undue Elevation of Procalcitonin in Pediatric Paracetamol Intoxication is Not Explained by Liver Cell Injury Alone","volume":"17","author":"E Tschiedel","year":"2018","journal-title":"Ann Hepatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1097\/MEG.0000000000000862","article-title":"Elevated procalcitonin is associated with bacterial infection during acute liver failure only when unrelated to acetaminophen intoxication","volume":"29","author":"M Mallet","year":"2017","journal-title":"European journal of gastroenterology & hepatology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.2165\/00044011-200323020-00006","article-title":"Adverse Effects of Intravenous N-Acetylcysteine","volume":"23","author":"H Sanaei-Zadeh","year":"2003","journal-title":"Clin Drug Invest"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1442-5519.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T08:32:05Z","timestamp":1627547525000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1442-5519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":7,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,6,15]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1442-5519","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}