{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:39:58Z","timestamp":1767339598675,"version":"3.37.3"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and Objective Sterile donor tomography enables the detection of corneal tissues with refractive anomalies. The aim of this study was to determine the curvature and thickness of donor corneas to support proper selection in the eye bank.<\/jats:p><jats:p>\n          Methods 704 donor corneas (Klaus Faber Center, LIONS Eye Bank Saar-Lor-Lux, Trier\/Westpfalz, in Homburg\/Saar) were measured using the anterior segment optical coherence tomograph (AS-OCT) CASIA 2 (Tomey Corp., Nagoya, Japan). The corneoscleral discs were measured in their cell culture flask, which was positioned in a holder on the chin rest of the AS-OCT, after conversion to medium II (with 6% dextran T-500). The measured raw data were analysed and processed in MATLAB (MathWorks Inc., Natick, Massachusetts, USA), after which the refractive power of the steep and flat meridian at the anterior and posterior surface and the central corneal thickness (CCT) of the donor corneas were determined. Results values are expressed as mean x\u0305 \u00b1 standard deviation SD.<\/jats:p><jats:p>\n          Results The mean refractive power of the steep\/flat meridian at the anterior surface was 45.4\u2009\u00b1\u20091.8\u2009D\/44.0\u2009\u00b1\u20091.3\u2009D, the corresponding values for the posterior surface were \u2212\u20096.2\u2009\u00b1\u20090.3\u2009D\/\u2212\u20095.9\u2009\u00b1\u20090.2\u2009D, and the mean CCT was 616.3\u2009\u00b1\u200985.1\u2009\u00b5m. Of the 704 (100%) measured donor tissues, 590 (83.8%)\/670 (95.2%) donor corneas showed no anomaly beyond respectively x\u0305\u2009\u00b1\u20092\u2009SD\/x\u0305\u2009\u00b1\u20093\u2009SD among the 5 examined parameters. 72 (10.3%)\/23 (3.3%) donor corneas had only 1 anomaly, 26\u00a0(3.7%)\/10 (1.4%) had 2 anomalies, 10\u00a0(1.4%)\/1 (0.1%), 3\u00a0anomalies, 5 (0.7%)\/0 (0.0%), 4 anomalies, and 1 (0.1%)\/0\u00a0(0.0%), 5 anomalies.<\/jats:p><jats:p>\n          Conclusions AS-OCT provides an objective and sterile screening method to identify corneal tissues with curvature anomalies in order to further optimise donor selection in the eye bank. To avoid postoperative refractive surprises, donor corneas with a total refractive power that deviates &gt;\u2009\u00b1\u20093\u2009SD from the mean should not be used for penetrating or anterior lamellar keratoplasty, but may be suitable for posterior lamellar keratoplasty (DMEK or DSAEK). In the future, sterile donor tomography could enable: (1) the harmonisation of donor and recipient tomography, which may minimise residual astigmatism for a particular donor-recipient pair; and (2) the improvement of IOL power calculation in a classical triple procedure by means of regression analysis between pre- and postoperative total refractive power of corneal grafts.<\/jats:p>","DOI":"10.1055\/a-1443-5451","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T22:35:38Z","timestamp":1624401338000},"page":"688-692","source":"Crossref","is-referenced-by-count":13,"title":["OCT Application for Sterile Corneal Graft Screening in the Eye Bank"],"prefix":"10.1055","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0452-3039","authenticated-orcid":false,"given":"Adrien","family":"Quintin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center (UKS), Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u00efc","family":"Hamon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center (UKS), Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"M\u00e4urer","sequence":"additional","affiliation":[{"name":"Institute of Experimental Ophthalmology, Saarland University, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Langenbucher","sequence":"additional","affiliation":[{"name":"Institute of Experimental Ophthalmology, Saarland University, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-8204","authenticated-orcid":false,"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center (UKS), Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/00003226-200203000-00011","article-title":"Objective screening methods for prior refractive surgery in donor tissue","volume":"21","author":"P J Ousley","year":"2002","journal-title":"Cornea"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/00003226-200211000-00002","article-title":"Use of a portable topography machine for screening donor tissue for prior refractive surgery","volume":"21","author":"P J Ousley","year":"2002","journal-title":"Cornea"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1097\/00003226-200111000-00016","article-title":"Evaluation of donor tissue with a new videokeratoscope: the Keratron Scout","volume":"20","author":"J Stoiber","year":"2001","journal-title":"Cornea"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/00003226-199907000-00007","article-title":"New screening methods for donor eye-bank eyes","volume":"18","author":"M A Terry","year":"1999","journal-title":"Cornea"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1097\/ICO.0b013e3181c325cc","article-title":"Donor corneas misidentified with prior laser in situ keratomileusis","volume":"29","author":"S J Kang","year":"2010","journal-title":"Cornea"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1001\/archopht.122.5.686","article-title":"Slitlamp, specular, and light microscopic findings of human donor corneas after laser-assisted in situ keratomileusis","volume":"122","author":"V V Mootha","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1001\/archopht.123.5.707-c","article-title":"Predictive value of slitlamp examinations in screening donor corneas for prior refractive surgery","volume":"123","author":"D E Vavra","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1007\/s00347-018-0801-2","article-title":"[Concept for 3D measurement of corneal donor tissue using a clinical OCT]","volume":"116","author":"S M\u00e4urer","year":"2019","journal-title":"Ophthalmologe"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"16001","DOI":"10.1117\/1.JBO.22.1.016001","article-title":"Optical coherence tomography-based topography determination of corneal grafts in eye bank cultivation","volume":"22","author":"A Damian","year":"2017","journal-title":"J Biomed Opt"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1097\/ICO.0000000000000761","article-title":"In vitro corneal tomography of donor cornea using anterior segment OCT","volume":"35","author":"E Janunts","year":"2016","journal-title":"Cornea"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/00003226-200301000-00011","article-title":"Optical coherence tomography for the detection of laser in situ keratomileusis in donor corneas","volume":"22","author":"S G Priglinger","year":"2003","journal-title":"Cornea"},{"key":"ref12","first-page":"223","volume-title":"Anterior Segment OCT: Application to improve Graft Selection for corneal Transplantation","author":"B Seitz","year":"2021"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002543","article-title":"Thickness and curvature changes of human corneal grafts in dextran-containing organ culture medium before keratoplasty","author":"L Hamon","year":"2020","journal-title":"Cornea"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/BF01268097","article-title":"Causes of high astigmatism after penetrating keratoplasty","volume":"85","author":"V P Hoppenreijs","year":"1993","journal-title":"Doc Ophthalmol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/eye.1995.98","article-title":"The Bowman Lecture","volume":"9","author":"G OH Naumann","year":"1995","journal-title":"Eye (Lond)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/S0161-6420(03)00659-6","article-title":"Impact of graft diameter on corneal power and the regularity of postkeratoplasty astigmatism before and after suture removal","volume":"110","author":"B Seitz","year":"2003","journal-title":"Ophthalmology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0002-9394(85)90362-9","article-title":"Postoperative astigmatism after central vs. eccentric penetrating keratoplasties","volume":"99","author":"G van Rij","year":"1985","journal-title":"Am J Ophthalmol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1001\/archopht.1988.01060140388039","article-title":"Configuration of corneal trephine opening using five different trephines in human donor eyes","volume":"106","author":"G van Rij","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1007\/s00417-018-4088-4","article-title":"Negative impact of dextran in organ culture media for pre-stripped tissue preservation on DMEK (Descemet membrane endothelial keratoplasty) outcome","volume":"256","author":"A Abdin","year":"2018","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1097\/ICO.0000000000000937","article-title":"Role of the endothelial layer in the deswelling process of organ-cultured human corneas before transplantation","volume":"35","author":"A C Schnitzler","year":"2016","journal-title":"Cornea"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.zemedi.2020.05.006","article-title":"\u201cHarmonization\u201d of donor and recipient tomography in corneal transplantation","volume":"31","author":"S M\u00e4urer","year":"2021","journal-title":"Z Med Phys"},{"key":"ref24","first-page":"197","volume-title":"Astigmatismus bei Keratoplastik","author":"B Seitz","year":"2000"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-020-01256-6","article-title":"[Comparison of sterile donor tomography in the eye bank and graft tomography after penetrating keratoplasty]","author":"A Quintin","year":"2020","journal-title":"Ophthalmologe"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1443-5451.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T22:36:33Z","timestamp":1624401393000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1443-5451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":23,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2021,6,22]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1443-5451","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"type":"print","value":"0023-2165"},{"type":"electronic","value":"1439-3999"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}