{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:04:53Z","timestamp":1785369893016,"version":"3.55.0"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Background: The use of peroral endoscopic myotomy (POEM) for achalasia has a high incidence of post-procedural gastroesophageal reflux (GER). Transoral incisionless fundoplication (TIF) may be an ideal endoscopic treatment. We report our experience with the use of post-POEM TIF.<\/jats:p><jats:p>\n               Methods: In this multicenter retrospective study, post-POEM patients with GER who underwent TIF were included. The study end points were: (i) technical success; (ii) safety; (iii) effectiveness (changes in symptoms, scores, proton pump inhibitor [PPI] use, pH studies).<\/jats:p><jats:p>\n               Results: 12 patients underwent TIF after POEM, nine of whom had daily symptoms, with 91.7% requiring twice daily (BID) PPIs. Technical success was achieved in all patients. Two adverse events occurred. There were significant decreases in the percentage of patients on BID PPIs (P = 0.03), frequency of daily symptoms (P = 0.03), Reflux Severity Index questionnaire, and GERD Health-related Quality of Life scores (P = 0.03 and P = 0.003; n = 6). pH studies performed in seven of the patients showed a significant reduction in the mean DeMeester score (P = 0.05) and mean percentage acid exposure time (P = 0.04). <\/jats:p><jats:p>\n               Conclusion: Our experience suggests that TIF may be effective and safe in treating GER after POEM. Larger prospective trials are needed.<\/jats:p>","DOI":"10.1055\/a-1446-8953","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T22:56:37Z","timestamp":1622242597000},"page":"305-309","source":"Crossref","is-referenced-by-count":25,"title":["Is transoral incisionless fundoplication (TIF) an answer to post-peroral endoscopic myotomy gastroesophageal reflux? A multicenter retrospective study"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-3801","authenticated-orcid":false,"given":"Olaya I.","family":"Brewer Gutierrez","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of California Irvine, Irvine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros C.","family":"Benias","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Lenox Hill Hospital, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Sedarat","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Ronald Reagan UCLA Medical Center, Santa Monica, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad H.","family":"Dbouk","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gala","family":"Godoy Brewer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of California Irvine, Irvine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick I.","family":"Okolo III","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Lenox Hill Hospital, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia I.","family":"Canto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouen A.","family":"Khashab","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1055\/s-0029\u20131244080","article-title":"Peroral endoscopic myotomy (POEM) for esophageal achalasia","volume":"42","author":"H Inoue","year":"2010","journal-title":"Endoscopy"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1053\/j.gastro.2013.04.057","article-title":"Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study","volume":"145","author":"D von Renteln","year":"2013","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/SLA.0000000000002311","article-title":"Laparoscopic Heller myotomy versus peroral endoscopic myotomy (POEM) for achalasia: a systematic review and meta-analysis","volume":"267","author":"F Schlottmann","year":"2018","journal-title":"Ann Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.gie.2017.10.022","article-title":"GERD after per-oral endoscopic myotomy as compared with Heller\u2019s myotomy with fundoplication: a systematic review with meta-analysis","volume":"87","author":"A 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