{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:51:10Z","timestamp":1791942670600,"version":"4.3.4"},"reference-count":61,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Kachexie wird als multifaktorielles Syndrom definiert, das durch einen unfreiwillig fortschreitenden Gewichtsverlust infolge einer Verringerung der Skelettmuskelmasse mit oder ohne Reduktion des Fettgewebes gekennzeichnet ist. Der Abbau von Muskelgewebe wird als Sarkopenie bezeichnet. Diese wird klinisch als Verlust von Muskelmasse und\/oder Muskelkraft definiert, wobei der Verlust von Muskelkraft im Vordergrund steht. Mit Sarkopenie verbunden ist der Zustand der Myosteatose, der durch eine Zunahme der intra- und extrazellul\u00e4ren Fettspeicher gekennzeichnet ist und mit einer verminderten Muskelfunktion einhergeht. Kachexie ist f\u00fcr den Tod von mindestens 20% aller Krebspatienten mitverantwortlich. Die Inzidenz variiert bei diesen Patienten je nach Art der Erkrankung zwischen 80% f\u00fcr Patienten mit Magen- und Bauchspeicheldr\u00fcsenkrebs, 50% f\u00fcr Patienten mit Lungen-, Dickdarm- und Prostatakrebs sowie etwa 40% f\u00fcr Patienten mit Brustkrebs oder Leuk\u00e4mie. Hierbei ist eine\n\t\t\t\t\tUnterscheidung zwischen tumorassoziierter Kachexie und einer durch Nebenwirkungen und Komplikationen der onkologischen Therapie bedingten Kachexie oft schwierig. Das wesentliche klinische Merkmal der Kachexie ist ein unfreiwilliger Gewichtsverlust, der sich jedoch nicht immer klinisch manifestiert, sodass die Identifizierung von Risikopatienten erheblich erschwert ist. Nicht nur das Langzeit-Outcome der Patienten wird von Kachexie und Sarkopenie beeinflusst. Auch die unmittelbaren postoperativen Komplikationsraten (Morbidit\u00e4t) werden erh\u00f6ht und haben tiefgreifende Auswirkungen auf die Krankheitslast und das Leiden der Patienten nach einer chirurgischen Behandlung. Kachexie, Sarkopenie und Myosteatose sind somit f\u00fcr den klinischen Alltag hochrelevante Parameter, die einen signifikanten Einfluss auf das postoperative Outcome der Patienten haben. Es wurden verschiedene Methoden entwickelt, um die fr\u00fchzeitige Identifizierung von Patienten mit einem erh\u00f6hten Risiko zu\n\t\t\t\t\tverbessern. Diese bieten die M\u00f6glichkeit, ungewollten Gewichtsverlust, verringerte Muskelkraft und die Fitness der Patienten zu testen. Derartige Ma\u00dfnahmen sollten Teil unserer t\u00e4glichen klinischen Routine werden, um diejenigen Patienten mit dem h\u00f6chsten postoperativen Risiko zu erkennen. Entsprechend k\u00f6nnen neuartige Pr\u00e4konditionierungskonzepte f\u00fcr bestimmte Patientengruppen in der Lage sein, die postoperative Morbidit\u00e4t zu verringern.<\/jats:p>","DOI":"10.1055\/a-1447-1259","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T22:30:38Z","timestamp":1624314638000},"page":"277-282","source":"Crossref","is-referenced-by-count":4,"title":["Der Einfluss von Kachexie und Sarkopenie auf das postoperative Outcome"],"prefix":"10.1055","volume":"146","author":[{"given":"Gregory","family":"van der Kroft","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, Uniklinik RWTH Aachen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W. 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