{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:19:18Z","timestamp":1670285958980},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"09\/10","funder":[{"name":"Landeszentrum Gesundheit Nordrhein-\nWestfalen gef\u00f6rdert","award":["2010\/S250-288194"],"award-info":[{"award-number":["2010\/S250-288194"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychother Psychosom Med Psychol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Ziel der Studie Ziel der Studie war es, H\u00e4ufigkeit, Lokalisation,\nIntensit\u00e4t, Qualit\u00e4t und Chronifizierungsgrad von Schmerzen bei\nMenschen mit vorgeburtlichen Contergansch\u00e4digungen\n(Thalidomid-Embryopathie) darzustellen sowie die Zusammenh\u00e4nge mit\nbiopsychosozialen Faktoren n\u00e4her zu untersuchen.<\/jats:p><jats:p>\n          Methodik Erstmalig wurde eine Gruppe von 202 contergangesch\u00e4digten\nMenschen aus Nordrhein-Westfalen sowohl physisch auf das Muster der\nUrsprungssch\u00e4digung, als auch psychisch mittels eines strukturierten\ndiagnostischen Interviews (SKID I &amp; SKID II) untersucht. Diese\nUntersuchungsdaten wurden mit einem standardisierten Schmerzinterview (MPSS)\nsowie Fragebogenangaben zu weiteren schmerzbezogenen (SF-36, PainDetect) und\nsoziodemografischen Variablen zusammengef\u00fchrt und analysiert.\nF\u00fcr die Analyse wurden letztlich 167 vollst\u00e4ndige\nDatens\u00e4tze ber\u00fccksichtigt.<\/jats:p><jats:p>\n          Ergebnisse Die Schmerpr\u00e4valenz betrug 94,0%. Die Mehrzahl\n(107 TN, 54,0%) wies im MPSS bereits fortgeschrittene\nChronifizierungsgrade auf: 63 TN mit Stadium II (37,7%) bzw. 44 TN mit\nStadium III (26,3%). Bei 74 Studienteilnehmern (44,3%) lag im\nPainDetect eine m\u00f6gliche oder wahrscheinliche neuropathische\nSchmerzkomponente vor. Signifikante Zusammenh\u00e4nge mit\nSchmerzchronifizierung zeigten sich bei Schmerzlokalisation im\nH\u00fcftbereich (p&lt;0,001) sowie bei dem Vorliegen von psychischen\nSt\u00f6rungen (p=0,001), insbesondere majoren Depressionen\n(p&lt;0,001), somatoformen und substanzbezogenen St\u00f6rungen (je\np=0,001). Soziale Variablen erwiesen sich hierbei ebenso als\nnicht-signifikant (p=0,094 f\u00fcr Alleinleben, p=0,122\nf\u00fcr Erwerbslosigkeit, p=0,167 f\u00fcr Nichtakademiker), wie\ndie Versorgungssituation (p=0,191 f\u00fcr\nPflegebed\u00fcrftigkeit) und das zugrundeliegende organische\nSch\u00e4digungsmuster (p=0,229 f\u00fcr\nH\u00f6rsch\u00e4digungen, p=0,764 f\u00fcr Dysmelien).<\/jats:p><jats:p>\n          Schlussfolgerungen Contergangesch\u00e4digte Menschen leiden\nh\u00e4ufig unter einer eigenst\u00e4ndigen Schmerzkrankheit, die als\nthalidomid-induzierte Folgesch\u00e4digung verstanden werden kann . Es\nbesteht ein starker Zusammenhang zwischen fortgeschrittener\nSchmerzchronifizierung und dem Vorhandensein von psychischen St\u00f6rungen,\nwelcher in der einer spezialisierten und individualisierten multimodalen\nSchmerzbehandlung besondere Ber\u00fccksichtigung finden sollte.<\/jats:p>","DOI":"10.1055\/a-1457-2846","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T22:58:00Z","timestamp":1619737080000},"page":"370-380","source":"Crossref","is-referenced-by-count":4,"title":["Chronische Schmerzen bei Menschen mit Thalidomid-Embryopathie Eine\nexplorative Analyse zu Pr\u00e4valenz, schmerzbezogenen Merkmalen und\nbiopsychosozialen Faktoren"],"prefix":"10.1055","volume":"71","author":[{"given":"Alexander","family":"Niecke","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Psychosomatik und Psychotherapie,\nMedizinische Fakult\u00e4t und Uniklinik, Universit\u00e4t zu\nK\u00f6ln, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Psychosomatik und Psychotherapie,\nMedizinische Fakult\u00e4t und Uniklinik, Universit\u00e4t zu\nK\u00f6ln, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Albus","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Psychosomatik und Psychotherapie,\nMedizinische Fakult\u00e4t und Uniklinik, Universit\u00e4t zu\nK\u00f6ln, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"L\u00fcngen","sequence":"additional","affiliation":[{"name":"Fakult\u00e4t Wirtschafts- und Sozialwissenschaften, Hochschule\nOsnabr\u00fcck, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Pfaff","sequence":"additional","affiliation":[{"name":"IMVR - Institut f\u00fcr Medizinsoziologie, Versorgungsforschung und\nRehabilitationswissenschaft der Humanwissenschaftlichen Fakult\u00e4t und der\nMedizinischen Fakult\u00e4t, Universit\u00e4t zu K\u00f6ln,\nDeutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Samel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Stastistik und Bioinformatik,\nMediziische Fakult\u00e4t, Universit\u00e4t zu K\u00f6ln,\nDeutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus M.","family":"Peters","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Orthop\u00e4die und Osteologie, Dr Becker\nRhein-Sieg-Klinik, Numbrecht, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/tera.1420380303","article-title":"A short history of thalidomide embryopathy","volume":"38","author":"W Lenz","year":"1988","journal-title":"Teratology"},{"key":"ref2","volume-title":"Der Contergan-Fall: eine unvermeidbare Arzneimittelkatastrophe? 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