{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T11:20:43Z","timestamp":1722943243030},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Fourniersche Gangr\u00e4n (FG) ist eine sporadische, lebensbedrohliche, nekrotisierende Infektion des Perineums, der Perinealregion und des \u00e4u\u00dferen Genitales. Aus der Literatur gibt es einige Hinweise darauf, dass die Prognose der Erkrankung in den letzten Jahren nicht wesentlich verbessert werden konnte. Daher wurde eine schnelle Evidenzanalyse mittels Literaturrecherche in MEDLINE aus den aktuellen Publikationen des Jahres 2020 durchgef\u00fchrt, um mittels neuer Aspekte zu erm\u00f6glichen, die Versorgungssituation der betroffenen Patienten zu verbessern und weitere Forschungsvorhaben ideal zu planen. Insgesamt konnten f\u00fcr dieses Review 18 Publikationen ber\u00fccksichtigt werden. Bei 15 dieser Arbeiten handelt es sich um Orginalarbeiten sowie 3 systematische Reviews. Bez. der Orginalarbeiten handelt es sich um 12 retrospektive Fallserien, 2 epidemiologische und eine prospektive Studie. 2 der systematischen Reviews inkludieren ebenfalls eine Metaanalyse. Die Mehrzahl der Autoren dieser Publikationen kommt unter anderem zu der Schlussfolgerung, dass die FG weiterhin eine ernsthafte Erkrankung mit teils inakzeptablen Mortalit\u00e4tsraten f\u00fcr die moderne Medizin ist und es in der Therapie weiterhin Optimierungsbedarf gibt. Weiterhin wurden neue Risikofaktoren identifiziert, die mit einer erh\u00f6hten Mortalit\u00e4t bei FG Patienten assoziiert sind. Es handelt sich um eine Dyslipoprotein\u00e4mie, Diabetes mellitus, Herzerkrankungen und akutes sowie chronisches Nierenversagen. 4 der inkludierten Arbeiten untersuchten den Zusammenhang des Auftretens von FG und der Einnahme oraler Antidiabetika, SGLT2- sowie DPP4-Hemmern. Keine Studie konnte dabei einen signifikanten Zusammenhang nachweisen, insbesondere eine Metaanalyse mit 84 Studien nicht. Vielversprechende Konzepte f\u00fcr die Wundbehandlung sind die hyperbare Oxygenierung (HBO), der vakuum-assistierte Wundverschluss und Wundkonditionierung mittels Larven. Zusammenfassend ist die FG ein seltenes, aber immer noch potenziell vital bedrohliches Krankheitsbild. Die Prognose konnte in den letzten Jahren nicht verbessert werden. Daher ist eine weitere Therapieoptimierung dringend erforderlich. Dies kann nur durch weitere Studien erreicht werden. Aufgrund der Seltenheit der Erkrankung sehen wir die M\u00f6glichkeit dies mit einer nationalen Registerstudie zu erreichen. Zus\u00e4tzlich k\u00f6nnen aus dem Register Risikostratefizierungen erarbeitet werden, welche Patienten z.\u200aB. von einer Therapie in einem Zentrum oder bestimmten Wundkonditionierungen profitieren.<\/jats:p>","DOI":"10.1055\/a-1472-5553","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T22:45:45Z","timestamp":1619045145000},"page":"360-366","source":"Crossref","is-referenced-by-count":1,"title":["Neue Aspekte zur Fournierschen Gangr\u00e4n \u2013 Ein Rapid Review"],"prefix":"10.1055","volume":"52","author":[{"given":"Jennifer","family":"Kranz","sequence":"additional","affiliation":[{"name":"St-Antonius-Hospital gGmbH, Klinik f\u00fcr Urologie und Kinderurologie, Eschweiler"},{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Urologie, Universit\u00e4tsklinikum Halle (Saale), Halle (Saale)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiree L.","family":"Dr\u00e4ger","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsmedizin Rostock, Urologische Klinik und Poliklinik, Rostock"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Schneidewind","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsmedizin Rostock, Urologische Klinik und Poliklinik, Rostock"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"ref1","first-page":"360","article-title":"Desperate need for better management in Fournier\u00b4s gangrene","volume":"71","author":"J Kranz","year":"2018","journal-title":"Cent European J Urol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jamcollsurg.2016.11.012","article-title":"Low-volume versus High-volume centers and management of Founier\u02bcs Gangrene in Washington State","volume":"224","author":"N Osburn","year":"2017","journal-title":"J Am Coll Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijsu.2017.02.067","article-title":"Microbiological aspects of Fournier's gangrene","volume":"40","author":"T Yilmazlar","year":"2017","journal-title":"Int J Surg"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00120-021-01461-4","article-title":"Contemporary practice patterns in the treatment of Fournier\u02bcs gangrene in German academic medicine and their implications for planning a registry study","author":"J Kranz","year":"2021","journal-title":"Urologe A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.urology.2016.09.021","article-title":"Contemporary trends in the inpatient management of Fournier\u02bcs gangrene: Predictors of length of stay and mortality based on population-based sample","volume":"102","author":"J Furr","year":"2017","journal-title":"Urology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.urology.2012.12.041","article-title":"Causative pathogens, antibiotic sensitivity, resistance patterns, and severity in a contemporary series of Fournier's gangrene","volume":"4","author":"M A Bjurlin","year":"2013","journal-title":"Urology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jinf.2017.09.015","article-title":"Emergence of multi-drug resistant organisms (MDROs) causing fournier's gangrene","volume":"76","author":"L Chia","year":"2018","journal-title":"J Infect"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11255-014-0897-5","article-title":"Evaluation of the utility of different scoring systems (FGSI, LRINEC and NLR) in the management of Fournier's gangrene","volume":"47","author":"O Bozkurt","year":"2015","journal-title":"Int Urol Nephrol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000445695","article-title":"Fournier\u02bcs gangrene: Epidemiology and outcomes in the general US population","volume":"97","author":"M D Sorensen","year":"2016","journal-title":"Urol Int"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/j.1464-410X.2012.11082.x","article-title":"Is there a need for the Fournier\u02bcs gangrene severity index? Comparison of scoring systems for outcome prediction in patients with Fournier\u02bcs gangrene","volume":"110","author":"F Roghmann","year":"2012","journal-title":"BJU Int"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"800","DOI":"10.5489\/cuaj.3192","article-title":"Analysis of prognostic factors affecting mortality in Fournier\u02bcs gangrene: A study of 72 cases","volume":"9","author":"M Tarchouli","year":"2015","journal-title":"Can Urol Assoc J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/codi.12396","article-title":"Treatment, outcome and quality of life after Fournier\u02bcs gangrene: a multicentre study","volume":"15","author":"R Czymek","year":"2013","journal-title":"Colorectal Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/iwj.12812","article-title":"Prognostic factors and treatment outcomes for patients with Fournier\u02bcs gangrene: a retrospective study","volume":"14","author":"K S Hong","year":"2017","journal-title":"Int Wound J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40064-014-0783-8","article-title":"The evaluation of microbiology and prognosis of Fournier\u02bcs gangrene in past five years","volume":"4","author":"L M Tang","year":"2015","journal-title":"Springer Plus"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.5152\/tud.2016.14194","article-title":"Overview of the different scoring systems in Fournier\u02bcs gangrene and assessment of prognostic factors","volume":"42","author":"\u00d6 G Doluoglu","year":"2016","journal-title":"Turk J Urol"},{"key":"ref16","first-page":"541","article-title":"Gender does not affect the prognosis of Fournier\u02bcs gangrene: a casematched study","volume":"22","author":"P Sarkut","year":"2016","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/wound.2017.0730","article-title":"Fournier\u02bcs gangrene: A review and outcome comparison from 2009 to 2016","volume":"6","author":"M Ferretti","year":"2017","journal-title":"Adv Wound Care"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1046\/j.1365-2168.2000.01497.x","article-title":"Fournier\u02bcs gangrene: a review of 1726 cases","volume":"87","author":"N Eke","year":"2000","journal-title":"Br J Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"218e","DOI":"10.1016\/j.urology.2004.03.049","article-title":"Fournier\u02bcs gangrene: experience with 25 patients and use of Fournier\u02bcs gangrene severity index score","volume":"64","author":"C O Yeniyol","year":"2004","journal-title":"Urology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/00000658-197205000-00010","article-title":"Synergistic necrotizing cellulitis","volume":"175","author":"H H Stone","year":"1972","journal-title":"Ann Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1159\/000493898","article-title":"Significance of hyperbaric oxygenation in the treatment of Fournier\u02bcs gangrene: a comparative study","volume":"101","author":"P Anheuser","year":"2018","journal-title":"Urol Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12961-016-0155-7","article-title":"What are the best methodologies for rapid reviews of the research evidence for evidence-informed decision making in health policy and practice: a rapid review","volume":"14","author":"M M Haby","year":"2016","journal-title":"Health Res Policy Syst"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"62","author":"A Liberati","year":"2009","journal-title":"J Clin Epidemiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4103\/UA.UA_62_19","article-title":"Pattern and outcome of management of Fournier\u02bcs gangrene in a resource-constraint setting","author":"N P Agwu","year":"2020","journal-title":"Urol Ann"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1590\/1806-9282.66.4.479","article-title":"Association between atherogenic dyslipidemia and fournier\u02bcs gangrene","volume":"66","author":"S Akan","year":"2020","journal-title":"Rev Assoc Med Bras"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.05.056","article-title":"Fiurnier\u02bcs gangrene in females: Presentation and management at a tertiary center","author":"N J Beecroft","year":"2020","journal-title":"Urology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1097\/JU.0000000000001194","article-title":"Microorganisms and antibiogram patterns in Fournier\u02bcs gangrene: Contemporary experience from a single tertiary care center","volume":"204","author":"Becerra CM Castillejo","year":"2020","journal-title":"J Urol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.23736\/S0393-2249.20.03696-6","article-title":"Hyperbaric oxygen therapy reduces mortality in patients with Fournier\u02bcs gangrene \u2013 Results from a multi-institutional observational study","volume":"72","author":"M Creta","year":"2020","journal-title":"Minerva Urol Nefrol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.29271\/jcpsp.2020.01.67","article-title":"Comparison of mortality in Fournier\u02bcs gangrene with the two scoring systems","volume":"30","author":"S Egin","year":"2020","journal-title":"J Coll Physicians Surg Pak"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1055\/a-1260-2576","article-title":"Factors affecting length of stay in Fournier\u02bcs gangrene: a retrospective analysis of 10 years\u02bc data","author":"M Eksi","year":"2020","journal-title":"Aktuelle Urol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1111\/dom.14082","article-title":"Sodium-glucoce co-transporter-2 inhibitors and the risk of urosepsis: A multi-site, prevalent new-user cohort study","volume":"22","author":"A Fisher","year":"2020","journal-title":"Diabetes Obes Metab"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03170-7","article-title":"The role of vacuum-assisted closure (VAC) therapy in the management of Fournier\u02bcs gangrene: a retrospective multi-institutional cohort study","author":"V Iacovelli","year":"2020","journal-title":"World Journal of Urology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/bju.14998","article-title":"Mortality associated with Fournier\u02bcs gangrene remains unchanged over 25 years","volume":"125","author":"R S Radcliffe","year":"2020","journal-title":"BJU Int"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.6749","article-title":"Location of residence and mortality for patients diagnosed with Fournier\u02bcs gangrene","author":"R Wong","year":"2020","journal-title":"Can Urol Assoc J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12893-020-00916-3","article-title":"A retrospective case series of Fournier\u02bcs gangrene: necrotizing fasciitis in perineum and perianal region","volume":"20","author":"N Zhang","year":"2020","journal-title":"BMC Surg"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s13300-020-00771-8","article-title":"SGLT2 inhibitors and the risk of hospitalization for Fournier\u02bcs gangrene: A nested case-control study","volume":"11","author":"T Wang","year":"2020","journal-title":"Diabetes Ther"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e000985","DOI":"10.1136\/bmjdrc-2019-000985","article-title":"Real-world evidence on sodium-glucose cotransporter-2 inhibitor use and risk of Fourniers gangrene","volume":"8","author":"J Y Yang","year":"2020","journal-title":"BMJ Open Diab Res Care"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/iwj.13444","article-title":"Clinical study of Maggot therapy for Fournier\u02bcs gangrene","volume":"17","author":"A Fonseca-Munoz","year":"2020","journal-title":"Int Wound J"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02705-6","article-title":"Vacuum-assisted closure device in the postoperative wound care for Fournier\u02bcs gangrene: a systematic review","author":"D Franco-Buenaventura","year":"2020","journal-title":"International Journal of Urology and Nephrology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ijid.2019.12.030","article-title":"Fournier\u02bcs gangrene mortality: a 17-year systematic review and meta-analysis","volume":"92","author":"A E El-Qushayri","year":"2020","journal-title":"International Journal of Infectious Dieases"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/dom.13900","article-title":"Fournier\u02bcs gangrene and sodium-glucose co-transporter-2 inhibitors: A meta-analysis of randomized controlled trials","volume":"22","author":"G A Silverii","year":"2020","journal-title":"Diabetes Obes Metab"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ijscr.2020.11.037","article-title":"Sodium-glucose cotransporter-2 (SGLT2) inhibitor-induced euglycemic diabetic ketoacidosis complicating the perioperative management of a patient with type 2 diabetes mellitus (T2DM) and Fournier\u02bcs gangrene: A case 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