{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:56:35Z","timestamp":1770998195916,"version":"3.50.1"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The way by which 1-deamino-8-D-arginine vasopressin (DDAVP) acts on platelets remains unclear. Data from the literature tend to show that there is no definite effect on platelet activation, but recent work has suggested that a subtype of platelets, activated by the combined action of collagen and thrombin, was triggered by DDAVP. Moreover, platelet microparticles (PMPs), which have been shown to be procoagulant, have rarely been studied in this context. The goal of this study was to analyze the effects of DDAVP on PMPs' release through platelet activation.<\/jats:p><jats:p>\n          Methods\u2003Fifteen out of 18 consecutive patients undergoing a therapeutic test with DDAVP were included. They were suffering from factor VIII deficiency or from von Willebrand disease. The expression of P-selectin and PAC-1 binding on platelets and the numbers of circulating PMPs were evaluated ex vivo before and after DDAVP infusion. Peripheral blood was collected on CTAD to limit artifactual platelet activation.<\/jats:p><jats:p>\n          Results\u2003DDAVP induced a significant decrease of platelet counts and volume. Only small changes of P-selectin expression and PAC-1 binding were observed. Considering PMPs, two populations of patients could be defined, respectively, with (120%, n\u2009=\u20096) or without (21%, n\u2009=\u20097) an increase of PMPs after DDAVP. The decrease in platelet counts and volume remained significant in the group of responders.<\/jats:p><jats:p>\n          Conclusion\u2003This study shows that DDAVP induces the generation\/release of PMPs in some patients with factor VIII deficiency and von Willebrand disease 1\u2009hour after DDAVP infusion.<\/jats:p>","DOI":"10.1055\/a-1476-7768","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T23:30:34Z","timestamp":1623972634000},"page":"185-192","source":"Crossref","is-referenced-by-count":3,"title":["Effect of DDAVP on Platelet Activation and Platelet-Derived Microparticle Generation"],"prefix":"10.1055","volume":"42","author":[{"given":"Matthieu","family":"Persyn","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Biologique, CHU de Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Athanase","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Biologique, CHU de Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Trossa\u00ebrt","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique, CHU de Nantes, Nantes, France"},{"name":"Centre de Traitement de l'H\u00e9mophilie, CHU de Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Sigaud","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique, CHU de Nantes, Nantes, France"},{"name":"Centre de Traitement de l'H\u00e9mophilie, CHU de Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Ternisien","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique, CHU de Nantes, Nantes, France"},{"name":"Centre de Traitement de l'H\u00e9mophilie, CHU de Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie C.","family":"B\u00e9n\u00e9","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique, CHU de Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Fouassier","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique, CHU de Nantes, Nantes, France"},{"name":"Centre de Traitement de l'H\u00e9mophilie, CHU de Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(77)91197-7","article-title":"1-Deamino-8-d-arginine vasopressin: a new pharmacological approach to the management of haemophilia and von Willebrands' diseases","volume":"1","author":"P M 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