{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:54:14Z","timestamp":1785419654791,"version":"3.56.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant81802777"],"award-info":[{"award-number":["Grant81802777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Background\u2002Gastrointestinal stromal tumors (GISTs) and gastrointestinal leiomyomas (GILs) are the most common subepithelial lesions (SELs). All GISTs have malignant potential; however, GILs are considered benign. Current imaging cannot effectively distinguish GISTs from GILs. We aimed to develop an artificial intelligence (AI) system to differentiate these tumors using endoscopic ultrasonography (EUS).<\/jats:p><jats:p>Methods\u2002The AI system was based on EUS images of patients with histologically confirmed GISTs or GILs. Participants from four centers were collected to develop and retrospectively evaluate the AI-based system. The system was used when endosonographers considered SELs to be GISTs or GILs. It was then used in a multicenter prospective diagnostic test to clinically explore whether joint diagnoses by endosonographers and the AI system can distinguish between GISTs and GILs to improve the total diagnostic accuracy for SELs.<\/jats:p><jats:p>Results\u2002The AI system was developed using 10 439 EUS images from 752 participants with GISTs or GILs. In the prospective test, 132 participants were histologically diagnosed (36 GISTs, 44 GILs, and 52 other types of SELs) among 508 consecutive subjects. Through joint diagnoses, the total accuracy of endosonographers in diagnosing the 132 histologically confirmed participants increased from 69.7\u200a% (95\u200a% confidence interval [CI] 61.4\u200a%\u201376.9\u200a%) to 78.8\u200a% (95\u200a%CI 71.0\u200a%\u201384.9\u200a%; P\u200a=\u200a0.01). The accuracy of endosonographers in diagnosing the 80 participants with GISTs or GILs increased from 73.8\u200a% (95\u200a%CI 63.1\u200a%\u201382.2\u200a%) to 88.8\u200a% (95\u200a%CI 79.8\u200a%\u201394.2\u200a%; P\u200a=\u200a0.01).<\/jats:p><jats:p>Conclusions\u2002We developed an AI-based EUS diagnostic system that can effectively distinguish GISTs from GILs and improve the diagnostic accuracy of SELs.<\/jats:p>","DOI":"10.1055\/a-1476-8931","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T22:39:38Z","timestamp":1617835178000},"page":"251-261","source":"Crossref","is-referenced-by-count":47,"title":["An artificial intelligence system for distinguishing between gastrointestinal stromal tumors and leiomyomas using endoscopic ultrasonography"],"prefix":"10.1055","volume":"54","clinical-trial-number":[{"clinical-trial-number":"chictr2000039322","registry":"10.18810\/chictr"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-8767","authenticated-orcid":false,"given":"Xintian","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"},{"name":"Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-0418","authenticated-orcid":false,"given":"Han","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"},{"name":"Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"},{"name":"Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.gie.2017.02.022","article-title":"The role of endoscopy in subepithelial lesions of the GI tract","volume":"85","author":"A L Faulx","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1053\/j.semdp.2006.09.001","article-title":"Gastrointestinal stromal tumors: Pathology and prognosis at different sites","volume":"23","author":"M Miettinen","year":"2006","journal-title":"Semin Diagn 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