{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:25:58Z","timestamp":1758893158169},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Infektionskomplikationen nach Prostatabiopsie nehmen zu aufgrund zunehmender Antibiotikaresistenz insbesondere gegen\u00fcber Fluorchinolonen. Fluorchinolone sind als perioperative Antibiotikaprophylaxe in Deutschland durch das Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte (BfArM) nicht mehr zugelassen. <\/jats:p><jats:p>Die Leitliniengruppe Urologische Infektionen der Europ\u00e4ischen Gesellschaft f\u00fcr Urologie (EAU) hat k\u00fcrzlich eine Meta-Analyse in zwei Teilen auf der Basis randomisiert kontrollierter Studien (RCTs) ver\u00f6ffentlicht. Die transperineale Prostatabiopsie ist mit signifikant weniger Infektionskomplikationen assoziiert als die transrektale Biopsie und sollte deswegen bevorzugt werden. Sollte dennoch eine transrektale Biopsie durchgef\u00fchrt werden, sind eine intrarektale Reinigung mit Povidon-Jod sowie eine antibiotische Prophylaxe ohne Fluorchinolone zu verwenden. Als antibiotische Prophylaxestrategien kommen die zielgerichtete Prophylaxe nach Empfindlichkeitstestung der Enddarmflora, die augmentierte Prophylaxe mit mehreren Antibiotika und die empirische Mono-Prophylaxe mit Nicht-Fluorchinolonen in Frage. Daten aus RCTs liegen hier f\u00fcr Aminoglykoside, 3.\u200aGenerationscephalosporine und Fosfomycin trometamol vor.<\/jats:p>","DOI":"10.1055\/a-1478-2793","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T23:34:52Z","timestamp":1620862492000},"page":"356-359","source":"Crossref","is-referenced-by-count":1,"title":["Prostatabiopsie 2021 \u2013 Was ist aktuell?"],"prefix":"10.1055","volume":"52","author":[{"given":"Florian","family":"Wagenlehner","sequence":"additional","affiliation":[{"name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen, Klinik f\u00fcr Urologie, Kinderurologie und Andrologie, Giessen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Bonkat","sequence":"additional","affiliation":[{"name":"alta uro AG, Basel, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Pilatz","sequence":"additional","affiliation":[{"name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen, 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