{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T13:43:24Z","timestamp":1743947004718,"version":"3.37.3"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Der Einsatz moderner molekularer Technologien gab uns im letzten Jahrzehnt neue Einblicke in die komplexen Interaktionen des menschlichen Mikrobioms in Bezug auf Gesundheit und Krankheitsentstehung. Hierbei wurde unter anderem das Sterilit\u00e4tskonzept des Harntrakts verworfen, sodass man sich nun als Ziel gesetzt hat, die verschiedenen mikrobiellen Signaturen zu identifizieren, die mit diversen Erkrankungen assoziiert sind. So stehen Dysbalancen des Mikrobioms zunehmend im Verdacht, negative Auswirkungen auf diverse maligne und benigne Krankheitsbilder zu verursachen. K\u00fcrzlich konnten solche Zusammenh\u00e4nge auch f\u00fcr das Prostatakarzinom, Nierenzellkarzinom und Harnblasenkarzinom gezeigt werden. Das Ergebnis hiervon ist die Entdeckung potenziell neuer Biomarker zur Diagnostik und als Therapieziel der genannten Erkrankungen. F\u00fcr die Diagnostik einiger benigner Krankheitsbilder wie der interstitiellen Zystitis, der Dranginkontinenz und der chronischen Prostatitis bzw. dem chronischen Beckenschmerzsyndrom galt eine mikrobielle Beteiligung bislang als Ausschlusskriterium. Jedoch zeigen auch hier die aktuellen Studien, dass das patientenindividuelle Mikrobiom durchaus Einfluss auf Entstehung und Auspr\u00e4gung der jeweiligen Erkrankung haben kann.<\/jats:p>","DOI":"10.1055\/a-1478-2960","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T04:39:23Z","timestamp":1623213563000},"page":"338-344","source":"Crossref","is-referenced-by-count":1,"title":["Die Rolle des Mikrobioms bei urologischen Erkrankungen"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2234-3624","authenticated-orcid":false,"given":"Michael","family":"Atzler","sequence":"additional","affiliation":[{"name":"Urologische Klinik und Poliklinik, Klinikum der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Campus Gro\u00dfhadern, M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilo","family":"Westhofen","sequence":"additional","affiliation":[{"name":"Urologische Klinik und 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