{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:07:00Z","timestamp":1769728020520,"version":"3.49.0"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"DOI":"10.13039\/501100001321","name":"National Research\nFoundation","doi-asserted-by":"crossref","award":["2020R1A2C2101276"],"award-info":[{"award-number":["2020R1A2C2101276"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001321","name":"National Research\nFoundation","doi-asserted-by":"crossref","award":["2016R1A6A3A11930978"],"award-info":[{"award-number":["2016R1A6A3A11930978"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nIntroduction Despite the ethnic differences in 5-HTTLPR (S\nallele relates to better antidepressant response in Korean and Japanese people,\nwhile L allele with better response in Caucasians), it is unclear whether\n5-HTTLPR and its high expression locus rs25531 are\ninteractively associated with antidepressant treatment outcome. We investigated\nthe individual and interaction effects of these polymorphisms on antidepressant\ntreatment outcomes in the Korean population.<\/jats:p><jats:p>\nMethods A total of 464 Korean subjects with major depressive disorder\ncompleted 6 weeks of antidepressant monotherapy. Venous blood was extracted for\ngenotyping 5-HTTLPR and rs25531 by polymerase chain reaction and\nDNA sequencing. We used logistic regression analyses to verify the main and\ninteraction effects of 5-HTTLPR and rs25531 on response and\nremission after antidepressant treatment.<\/jats:p><jats:p>\nResults After adjusting for covariates, the SS genotype of\n5-HTTLPR was significantly associated with better treatment outcomes\n(p&lt;0.001, odds ratio [OR] [95% confidence interval\n(CI)]=2.435 [1.551, 3.823] in response; p&lt;0.001, OR [95%\nCI]=2.912 [1.730, 4.903] in remission), while G-containing genotype\n(AG+GG) of rs25531 was only associated with remission\n(p=0.034, OR [95% CI]=2.104 [1.058, 4.181]). The\ninteraction effect of 5-HTTLPR and rs25531 on response and\nremission was insignificant (all p&gt;0.05).<\/jats:p><jats:p>\nDiscussion Our findings suggest variations in allelic frequency and\nfunctionality of 5-HTTLPR and rs25531 among the different\nethnicities. We found a minor advantage of rs25531 in achieving\nremission. However, there was no interaction effect with 5-HTTLPR.<\/jats:p>","DOI":"10.1055\/a-1478-4574","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T23:36:05Z","timestamp":1620862565000},"page":"269-278","source":"Crossref","is-referenced-by-count":10,"title":["5-HTTLPR-rs25531 and Antidepressant Treatment Outcomes in\nKorean Patients with Major Depression"],"prefix":"10.1055","volume":"54","author":[{"given":"Yoo Jin","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Samsung Medical Center, Sungkyunkwan\nUniversity School of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinn-Won","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Health Sciences and have used the tri-allelic notationTechnology, SAIHST, Sungkyunkwan\nUniversity, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Kyung","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Samsung Medical Center, Sungkyunkwan\nUniversity School of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Clinical Research, Samsung Biomedical Research Institute,\nSeoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Clinical Research, Samsung Biomedical Research Institute,\nSeoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Statistics and Data Center, Samsung Medical Center, Seoul,\nKorea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doh Kwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Samsung Medical Center, Sungkyunkwan\nUniversity School of Medicine, Seoul, Korea"},{"name":"Department of Health Sciences and have used the tri-allelic notationTechnology, SAIHST, Sungkyunkwan\nUniversity, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/mp.2010.58","article-title":"Pharmacogenomics of antidepressants: what is next?","volume":"15","author":"J Licinio","year":"2010","journal-title":"Mol Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/sj.mp.4000425","article-title":"Polymorphism within the promoter of the serotonin transporter gene and\nantidepressant efficacy of fluvoxamine","volume":"3","author":"E Smeraldi","year":"1998","journal-title":"Mol 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(Berl)"}],"container-title":["Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1478-4574.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T23:32:38Z","timestamp":1636414358000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1478-4574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,12]]},"references-count":42,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2021,11,8]]},"published-print":{"date-parts":[[2021,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1478-4574","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0176-3679","1439-0795"],"issn-type":[{"value":"0176-3679","type":"print"},{"value":"1439-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,12]]}}}