{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:33:31Z","timestamp":1781530411554,"version":"3.54.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002The poor flexibility of large-bore EUS needles often leads to technical failure when sampling from the duodenum. The aim of this study was to evaluate the technical and diagnostic performances of a new Menghini tip 19G nitinol EUS needle for sampling pancreatic solid lesions in the head and uncinate process.<\/jats:p><jats:p>\n          Patients and methods\u2002This was a European prospective multicenter single-arm study. A maximum of four passes were allowed. In case of failure, different needles were permitted.<\/jats:p><jats:p>\n          Results\u2002We included 75 patients (51\u200a% males) with lesions in the head (n\u200a=\u200a68; 91\u200a%) and uncinate process (n\u200a=\u200a7; 9\u200a%) (mean size: 33\u200a\u00b1\u200a12 mm; number of passes: 1.8\u200a\u00b1\u200a0.9). Technical success was seen in 71 of 75 (94.7\u200a%). Diagnostic rates were 89.3\u200a% (67\/75) and 94.4\u200a% (67\/71) in the intention-to-treat (ITT) and per-protocol (PP) analysis, respectively. In the eight cases with failure, diagnosis was obtained with another needle (n\u200a=\u200a4), from another lesion (n\u200a=\u200a3) or with follow-up (n\u200a=\u200a1). A histological sample was obtained in 64 patients (ITT 85.3\u200a% and PP 90\u200a%) and immunohistochemistry was successfully performed in 13 of 15 lesions in which it was required. No differences between rapid on-site evaluation (ROSE) and non-ROSE groups were observed regarding diagnostic success (87.5\u200a% vs 91\u200a%, P\u200a=\u200a0.582) and diagnosis at the first pass (70\u200a% vs 81\u200a%, P\u200a=\u200a0.289). Number of passes was lower in the ROSE group (1.4\u200a+\u200a0.9 vs 2.2\u200a+\u200a0.7, P\u200a&lt;\u200a0.001). One adverse event was recorded (1.3\u200a%) consisting in a duodenal perforation after a single session EUS-ERCP. <\/jats:p><jats:p>\n          Conclusions\u2002The new nitinol Menghini tip 19G EUS needle showed high technical diagnostic success in safely sampling solid lesions in the head and uncinate process of the pancreas.<\/jats:p>","DOI":"10.1055\/a-1480-0428","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T08:29:22Z","timestamp":1629793762000},"page":"E1269-E1275","source":"Crossref","is-referenced-by-count":5,"title":["Performance of a new flexible 19 G EUS needle in pancreatic solid lesions located in the head and uncinate process: A prospective multicenter study"],"prefix":"10.1055","volume":"09","author":[{"given":"Angels","family":"Gin\u00e8s","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona \u2013 Endoscopy Unit, Barcelona. University of Barcelona, Spain"},{"name":"CIBEREHD Barcelona, Spain"},{"name":"IDIBAPS \u2013 Medicina, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Fusaroli","sequence":"additional","affiliation":[{"name":"Hospital of Imola \u2013 GI Unit, University of Bologna, Imola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Sendino","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona \u2013 Endoscopy Unit, Barcelona. University of Barcelona, Spain"},{"name":"CIBEREHD Barcelona, Spain"},{"name":"IDIBAPS \u2013 Medicina, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrada","family":"Seicean","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u2013 Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Z.","family":"Gimeno-Garcia","sequence":"additional","affiliation":[{"name":"Hospital Universitario de de  Sta Cruz de Tenerife \u2013 Service of Gastroenterology, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Gratac\u00f3s-Gin\u00e8s","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona \u2013 Endoscopy Unit, Barcelona. University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis K.","family":"Araujo","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona \u2013 Endoscopy Unit, Barcelona. University of Barcelona, Spain"},{"name":"IDIBAPS \u2013 Medicina, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Rodr\u00edguez-Carunchio","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona \u2013 Pathology Department, University of Vic \u2013 Central University of Catalonia (UVic-UCC), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Al\u00f3s","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona \u2013 Pathology Department, University of Vic \u2013 Central University of Catalonia (UVic-UCC), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lisotti","sequence":"additional","affiliation":[{"name":"Hospital of Imola \u2013 GI Unit, University of Bologna, Imola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cominardi","sequence":"additional","affiliation":[{"name":"Hospital of Imola \u2013 GI Unit, University of Bologna, Imola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona \u2013 Endoscopy Unit, Barcelona. University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00f2ria","family":"Fern\u00e1ndez-Esparrach","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona \u2013 Endoscopy Unit, Barcelona. University of Barcelona, Spain"},{"name":"CIBEREHD Barcelona, Spain"},{"name":"IDIBAPS \u2013 Medicina, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/MPA.0b013e3182546e79","article-title":"How good is endoscopic ultrasound-guided fine-needle aspiration in diagnosing the correct etiology for a solid pancreatic mass? A meta-analysis and systematic review.","volume":"42","author":"S R Puli","year":"2013","journal-title":"Pancreas"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s10620-011-1961-y","article-title":"Levels of evidence in endoscopic ultrasonography: A systematic review","volume":"57","author":"P Fusaroli","year":"2012","journal-title":"Digest Dis Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1055\/s-0043-109021","article-title":"Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline \u2013 Updated January 2017","volume":"49","author":"J M Dumonceau","year":"2017","journal-title":"Endoscopy"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1055\/s-0035-1553788","article-title":"EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part IV \u2013 EUS-guided interventions: General Aspects and EUS-guided Sampling (Short Version)","volume":"37","author":"C Jenssen","year":"2016","journal-title":"Ultraschall in der Medizin"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/MCG.0b013e3181fbde42","article-title":"Scientific publications in endoscopic ultrasonography: Changing trends in the third millennium","volume":"45","author":"P Fusaroli","year":"2011","journal-title":"J Clin Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1055\/s-0043-119219","article-title":"Technical aspects of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Technical Guideline","volume":"49","author":"M Polkowski","year":"2017","journal-title":"Endoscopy"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1055\/s-0032-1326268","article-title":"Randomized trial comparing the fanning with standard technique for endoscopic ultrasound-guided fine needle aspiration of solid pancreatic mass lesions","volume":"45","author":"J Y Bang","year":"2013","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1055\/s-2004-814316","article-title":"Comparison of EUS-guided 19-gauge Trucut needle biopsy with EUS-guided fine-needle aspiration","volume":"36","author":"S Varadarajulu","year":"2004","journal-title":"Endoscopy"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1055\/s-0029-1244074","article-title":"EUS-guided trucut biopsy in the diagnosis of gastric stromal tumors: a randomized crossover study","volume":"42","author":"G Fern\u00e1ndez-Esparrach","year":"2010","journal-title":"Endoscopy"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e0163056","DOI":"10.1371\/journal.pone.0163056","article-title":"Rapid on-site evaluation does not improve endoscopic ultrasound-guided fine needle aspiration adequacy in pancreatic masses: a meta-analysis and systematic review","volume":"11","author":"F Kong","year":"2016","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1038\/ajg.2011.119","article-title":"Influence of on-site cytopathology evaluation on the diagnostic accuracy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of solid pancreatic masses","volume":"106","author":"J Iglesias-Garcia","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/ajg.2015.262","article-title":"The clinical impact of immediate onsite cytopathology evaluation during endoscopic ultrasound-guided fine needle aspiration of pancreatic masses: a prospective multicenter randomized controlled trial","volume":"110","author":"S Wani","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/den.12594","article-title":"Randomized noninferiority trial comparing diagnostic yield of cytopathologist-guided versus 7 passes for EUS-FNA of pancreatic masses","volume":"28","author":"L S Lee","year":"2015","journal-title":"Dig Endosc"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/cyt.12071","article-title":"The presence of a cytopathologist increases the diagnostic accuracy of endoscopic ultrasound-guided fine needle aspiration cytology for pancreatic adenocarcinoma: a meta-analysis","volume":"24","author":"S Hebert-Magee","year":"2013","journal-title":"Cytopathology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/jgh.12431","article-title":"Impact of rapid on-site evaluation on the adequacy of endoscopic-ultrasound guided fine-needle aspiration of solid pancreatic lesions: a systematic review and meta-analysis","volume":"29","author":"A P Matynia","year":"2014","journal-title":"J Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1055\/a-1157-1657","article-title":"Novel design fine-needle biopsy needles are ready to take over the supremacy of fine-needle aspiration needles for sampling of solid pancreatic masses","volume":"52","author":"A Gin\u00e8s","year":"2020","journal-title":"Endoscopy"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/ajg.2010.108","article-title":"The prospective randomized, controlled trial of endoscopic ultrasound-guided fine-needle aspiration using 22 G and 19 G aspiration needles for solid pancreatic or peripancreatic masses","volume":"105","author":"T J Song","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"E24","DOI":"10.1055\/s-0033-1359212","article-title":"Evaluation of 19-gauge endoscopic ultrasonography aspiration needles using various echoendoscopes","volume":"1","author":"T Itoi","year":"2013","journal-title":"Endosc Int Open"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.gie.2016.01.068","article-title":"EUS Needle Identification Comparison and Evaluation study (with videos)","volume":"84","author":"S-J Tang","year":"2016","journal-title":"Gastrointest Endosc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1055\/a-0757-7714","article-title":"19 G nitinol needle versus 22 G needle for transduodenal endoscopic ultrasound-guided sampling of pancreatic solid masses: a randomized study","volume":"51","author":"A Laqui\u00e8re","year":"2019","journal-title":"Endoscopy"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.gie.2012.04.455","article-title":"Assessment of the technical performance of the flexible 19-gauge EUS-FNA needle","volume":"76","author":"S Varadarajulu","year":"2012","journal-title":"Gastrointest Endosc"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.gie.2009.10.027","article-title":"A lexicon for endoscopic adverse events: report of an ASGE workshop","volume":"71","author":"P B Cotton","year":"2010","journal-title":"Gastrointest Endosc"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1002\/0471445428","volume-title":"Statistical Methods for Rates and Proportions. 3rd ed","author":"J L Fleiss","year":"2003"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4103\/2303-9027.183976","article-title":"Pathologic evaluation of a new endoscopic ultrasound needle designed to obtain core tissue samples: A pilot study","volume":"5","author":"D G Adler","year":"2016","journal-title":"Endosc Ultrasound"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.gie.2016.08.048","article-title":"Comparison of the diagnostic performance of 2 core biopsy needles for EUS-guided tissue acquisition from solid pancreatic lesions","volume":"85","author":"M K Nayar","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/2050640615577533","article-title":"Comparison of 22G reverse beveled versus standard needle for endoscopic ultrasound-guided sampling of solid pancreatic lesions","volume":"3","author":"A Alatawi","year":"2015","journal-title":"United European Gastroenterol J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e0154401","DOI":"10.1371\/journal.pone.0154401","article-title":"Prospective study for comparison of endoscopic ultrasound-guided tissue acquisition using 25- and 22- gauge core biopsy needles in solid pancreatic masses","volume":"11","author":"S W Park","year":"2016","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1007\/s00464-013-2957-9","article-title":"Feasibility and yield of a novel 22-gauge histology EUS needle in patients with pancreatic masses: a multicenter prospective cohort study","volume":"27","author":"A Larghi","year":"2013","journal-title":"Surg Endosc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.gie.2011.08.049","article-title":"EUS-guided FNA for diagnosis of solid pancreatic neoplasms: a meta-analysis","volume":"75","author":"M J Hewitt","year":"2012","journal-title":"Gastrointest Endosc"}],"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1480-0428.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T08:32:23Z","timestamp":1629793943000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1480-0428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":29,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2021,7,16]]},"published-print":{"date-parts":[[2021,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1480-0428","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,16]]}}}