{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:26:30Z","timestamp":1760077590145},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2002The purpose of the study was to investigate the potential added value of 18F-FDG-PET\/MRI (functional information derived from PET) over standard diagnostic liver MRI (excellent soft tissue characterization) in diagnosing and staging suspected primary hepatobiliary malignancies including extrahepatic cholangiocarcinoma (ECC), intrahepatic cholangiocellular carcinoma (ICC) and gallbladder cancer (GBCA).<\/jats:p><jats:p>\n          Methods\u2002Twenty consecutive patients with suspected hepatobiliary malignancy were included in this retrospective study. All patients underwent combined whole-body (WB) 18F-FDG-PET\/MRI including contrast-enhanced MRI of the liver, contrast-enhanced WB-MRI and WB 18F-FDG-PET. Two experienced readers staged hepatobiliary disease using TNM criteria: first based on MRI alone and then based on combined 18F-FDG-PET\/MRI. Subsequently, the impact of FDG-PET\/MRI on clinical management compared to MRI alone was recorded. Histopathologic proof served as the reference standard.<\/jats:p><jats:p>\n          Results\u2002Hepatobiliary neoplasms were present in 16\/20\u00a0patients (ECC n\u200a=\u200a3, ICC n\u200a=\u200a8, GBCA n\u200a=\u200a5), two patients revealed benign disease, two were excluded. TNM staging with 18F-FDG-PET\/MRI was identical to MRI alone in 11\/18 (61.1\u200a%) patients and correctly changed the stage in 4\/18 (22.2\u200a%), resulting in a change in management for 2\/4 patients (11.1\u200a%). 18F-FDG-PET\/MRI was false-positive in 3\/18 cases (16.7\u200a%). Both MRI and 18F-FDG-PET\/MRI were falsely positive in 1 case without malignancy.<\/jats:p><jats:p>\n          Conclusions\u2002A small incremental benefit of 18F-FDG-PET\/MRI over standard MRI of the liver was observed. However, in some cases 18F-FDG-PET\/MRI may lead to false-positive findings. Overall there is seemingly limited role of 18F-FDG-PET\/MRI in patients with suspected hepatobiliary malignancy.<\/jats:p>","DOI":"10.1055\/a-1486-3671","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T05:08:51Z","timestamp":1623215331000},"page":"355-367","source":"Crossref","is-referenced-by-count":5,"title":["Diagnosis and staging of hepatobiliary malignancies: Potential incremental value of (18)F-FDG-PET\/MRI compared to MRI of the liver"],"prefix":"10.1055","volume":"60","author":[{"given":"Verena Carola","family":"Obmann","sequence":"additional","affiliation":[{"name":"Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Switzerland"},{"name":"Radiology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Grosse-Hokamp","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Cologne, Faculty of Medicine and University Hospital Cologne, Germany"},{"name":"Radiology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Alberts","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Inselspital University Hospital Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Fulton","sequence":"additional","affiliation":[{"name":"Akron Radiology Inc., Akron, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negin","family":"Rassouli","sequence":"additional","affiliation":[{"name":"Radiology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Cleveland Clinic Foundation, Hillcrest Hospital, Mayfield Heights, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Avril","sequence":"additional","affiliation":[{"name":"Radiology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin Anna","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Radiology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"issue":"05","key":"ref1","first-page":"306","article-title":"Simultaneous PET\/MRI vs PET\/CT in oncology. A systematic review","volume":"35","author":"C Riola-Parada","year":"2016","journal-title":"Revista espanola de medicina nuclear e imagen molecular"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1148\/radiol.2017170700","article-title":"Deep Learning MR Imaging-based Attenuation Correction for PET\/MR Imaging","volume":"286","author":"F Liu","year":"2018","journal-title":"Radiology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejrad.2017.09.007","article-title":"Improved clinical workflow for simultaneous whole-body PET\/MRI using high-resolution CAIPIRINHA-accelerated MR-based attenuation correction","volume":"96","author":"M T Freitag","year":"2017","journal-title":"European journal of radiology"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.mric.2016.12.001","article-title":"Attenuation Correction of PET\/MR Imaging","volume":"25","author":"Y Chen","year":"2017","journal-title":"Magnetic resonance imaging clinics of North America"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.zemedi.2012.08.003","article-title":"Attenuation correction for PET\/MR: problems, novel approaches and practical solutions","volume":"22","author":"A Martinez-Moller","year":"2012","journal-title":"Zeitschrift fur medizinische Physik"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.cpet.2016.05.010","article-title":"Clinical PET\/MR Imaging in Oncology: Future Perspectives","volume":"11","author":"A Kjaer","year":"2016","journal-title":"PET clinics"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2967\/jnumed.114.150318","article-title":"Combined PET\/MR: a technology becomes mature","volume":"56","author":"H F Wehrl","year":"2015","journal-title":"Journal of nuclear medicine: official publication, Society of Nuclear Medicine"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ejrad.2016.01.010","article-title":"PET\/MRI with diagnostic MR sequences vs PET\/CT in the detection of abdominal and pelvic cancer","volume":"85","author":"J Xin","year":"2016","journal-title":"European journal of radiology"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s12149-017-1164-5","article-title":"Comparison of 18F-FDG-PET\/CT and 18F-FDG-PET\/MR imaging in oncology: a systematic review","volume":"31","author":"A Singnurkar","year":"2017","journal-title":"Annals of nuclear medicine"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00259-019-04452-y","article-title":"PET\/MRI versus PET\/CT in oncology: a prospective single-center study of 330 examinations focusing on implications for patient management and cost considerations","volume":"47","author":"M E Mayerhoefer","year":"2020","journal-title":"European journal of nuclear medicine and molecular imaging"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00259-017-3809-y","article-title":"Comparison of 18F-FDG PET\/MRI and MRI for pre-therapeutic tumor staging of patients with primary cancer of the uterine cervix","volume":"45","author":"T Sarabhai","year":"2018","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.mric.2017.03.012","article-title":"PET\/MR Imaging in Gynecologic Oncology","volume":"25","author":"M A Ohliger","year":"2017","journal-title":"Magnetic resonance imaging clinics of North America"},{"issue":"07","key":"ref13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/RLU.0000000000001684","article-title":"Multiparametric Evaluation of Treatment Response to Neoadjuvant Chemotherapy in Breast Cancer Using Integrated PET\/MR","volume":"42","author":"J Wang","year":"2017","journal-title":"Clinical nuclear medicine"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s40336-016-0213-8","article-title":"Clinical PET\/MRI in neurooncology: opportunities and challenges from a single-institution perspective","volume":"5","author":"L Marner","year":"2017","journal-title":"Clinical and translational imaging"},{"issue":"05","key":"ref15","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1148\/rg.2015140029","article-title":"Diffusion-weighted and PET\/MR Imaging after Radiation Therapy for Malignant Head and Neck Tumors","volume":"35","author":"A Varoquaux","year":"2015","journal-title":"Radiographics: a review publication of the Radiological Society of North America, Inc"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.117.198663","article-title":"Non-oncologic Applications of PET\/CT and PET\/MR in Musculoskeletal, Orthopedic, and Rheumatologic Imaging: General Considerations, Techniques, and Radiopharmaceuticals","author":"A Gholamrezanezhad","year":"2017","journal-title":"J Nucl Med Technol"},{"issue":"05","key":"ref17","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00259-013-2660-z","article-title":"Comparison of PET\/CT and PET\/MRI hybrid systems using a 68Ga-labelled PSMA ligand for the diagnosis of recurrent prostate cancer: initial experience","volume":"41","author":"A Afshar-Oromieh","year":"2014","journal-title":"European journal of nuclear medicine and molecular imaging"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1148\/radiol.14140090","article-title":"Whole-body nonenhanced PET\/MR versus PET\/CT in the staging and restaging of cancers: preliminary observations","volume":"273","author":"M W Huellner","year":"2014","journal-title":"Radiology"},{"issue":"07","key":"ref19","doi-asserted-by":"crossref","first-page":"e0180349","DOI":"10.1371\/journal.pone.0180349","article-title":"18 F-FDG PET\/MR imaging in patients with suspected liver lesions: Value of liver-specific contrast agent Gadobenate dimeglumine","volume":"12","author":"J Kirchner","year":"2017","journal-title":"PloS one"},{"issue":"09","key":"ref20","doi-asserted-by":"crossref","first-page":"e0137285","DOI":"10.1371\/journal.pone.0137285","article-title":"Accuracy of [18F]FDG PET\/MRI for the Detection of Liver Metastases","volume":"10","author":"K Beiderwellen","year":"2015","journal-title":"PloS one"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s00259-016-3356-y","article-title":"PET\/MRI in pancreatic and periampullary cancer: correlating diffusion-weighted imaging, MR spectroscopy and glucose metabolic activity with clinical stage and prognosis","volume":"43","author":"B B Chen","year":"2016","journal-title":"European journal of nuclear medicine and molecular imaging"},{"issue":"07","key":"ref22","doi-asserted-by":"crossref","first-page":"e0180184","DOI":"10.1371\/journal.pone.0180184","article-title":"Quantitative assessment of simultaneous F-18 FDG PET\/MRI in patients with various types of hepatic tumors: Correlation between glucose metabolism and apparent diffusion coefficient","volume":"12","author":"E Kong","year":"2017","journal-title":"PloS one"},{"issue":"02","key":"ref23","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.acra.2020.01.026","article-title":"The Role of 18F-FDG PET\/MRI in the Assessment of Primary Intrahepatic Neoplasms","volume":"28","author":"F \u00c7elebi","year":"2021","journal-title":"Acad Radiol"},{"issue":"08","key":"ref24","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00259-019-04558-3","article-title":"Management implications of fluorodeoxyglucose positron emission tomography\/magnetic resonance in untreated intrahepatic cholangiocarcinoma","volume":"47","author":"C Ferrone","year":"2020","journal-title":"European journal of nuclear medicine and molecular imaging"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s13139-016-0440-y","article-title":"The Role of F-18 FDG PET\/CT in Intrahepatic Cholangiocarcinoma","volume":"51","author":"Y Lee","year":"2017","journal-title":"Nuclear medicine and molecular imaging"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.amjsurg.2011.07.025","article-title":"Positron Emission Tomography (PET) in Hepatobiliary and Pancreatic Malignancies \u2013 A Review","volume":"204","author":"B Y Lan","year":"2012","journal-title":"American journal of surgery"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1477-2574.2010.00280.x","article-title":"FDG-positron emission tomography\/computed tomography and standardized uptake value in the primary diagnosis and staging of hilar cholangiocarcinoma","volume":"13","author":"A T Ruys","year":"2011","journal-title":"HPB: the official journal of the International Hepato Pancreato Biliary Association"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1159\/000453009","article-title":"Imaging of Cholangiocarcinoma","volume":"32","author":"S C Olthof","year":"2016","journal-title":"Visceral medicine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"20130608","DOI":"10.1259\/bjr.20130608","article-title":"Gadoxetic acid-enhanced MRI for T-staging of gallbladder carcinoma: emphasis on liver invasion","volume":"87","author":"J Hwang","year":"2014","journal-title":"The British journal of radiology"},{"issue":"05","key":"ref30","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/jmri.24810","article-title":"MRI of cholangiocarcinoma","volume":"42","author":"K S Jhaveri","year":"2015","journal-title":"Journal of Magnetic Resonance Imaging"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40644-018-0140-1","article-title":"Added value of diffusion-weighted imaging in hepatic tumors and its impact on patient management","volume":"18","author":"J Taron","year":"2018","journal-title":"Cancer imaging: the official publication of the International Cancer Imaging Society"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1088\/0031-9155\/56\/10\/013","article-title":"Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system","volume":"56","author":"H Zaidi","year":"2011","journal-title":"Physics in medicine and biology"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10334-012-0330-y","article-title":"Sequential whole-body PET\/MR scanner: concept, clinical use, and optimisation after two years in the clinic. The manufacturer\u2019s perspective","volume":"26","author":"A Kalemis","year":"2013","journal-title":"Magnetic Resonance Materials in Physics, Biology and Medicine (journal article)"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"e012799","DOI":"10.1136\/bmjopen-2016-012799","article-title":"STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration","volume":"6","author":"J F Cohen","year":"2016","journal-title":"BMJ Open"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/RLU.0000000000000998","article-title":"Role of 18F-FDG PET\/CT Imaging in Intrahepatic Cholangiocarcinoma","volume":"41","author":"L Jiang","year":"2016","journal-title":"Clinical nuclear medicine"},{"issue":"01","key":"ref36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jhep.2006.03.009","article-title":"Impact of integrated positron emission tomography and computed tomography on staging and management of gallbladder cancer and cholangiocarcinoma","volume":"45","author":"H Petrowsky","year":"2006","journal-title":"Journal of hepatology"},{"issue":"01","key":"ref37","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.gassur.2003.10.003","article-title":"Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma","volume":"8","author":"C D Anderson","year":"2004","journal-title":"Journal of Gastrointestinal Surgery (journal article)"},{"issue":"11","key":"ref38","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/hpb.12282","article-title":"Impact of pre-operative positron emission tomography in gallbladder cancer","volume":"16","author":"U Leung","year":"2014","journal-title":"HPB: the official journal of the International Hepato Pancreato Biliary Association"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jamcollsurg.2007.07.002","article-title":"18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer","volume":"206","author":"C U Corvera","year":"2008","journal-title":"Journal of the American College of Surgeons"},{"issue":"05","key":"ref40","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/j.1572-0241.2007.01710.x","article-title":"Clinical role of 18F-FDG PET-CT in suspected and potentially operable cholangiocarcinoma: a prospective study compared with conventional imaging","volume":"103","author":"J Y Kim","year":"2008","journal-title":"Am J Gastroenterol"},{"issue":"02","key":"ref41","first-page":"e493","article-title":"Gallbladder Carcinoma, the Difficulty of Early Detection: A Case Report","volume":"8","author":"A E Graff","year":"2016","journal-title":"Cureus"},{"issue":"03","key":"ref42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12029-014-9597-8","article-title":"Gallbladder cancer, treatment failure and relapses: the peritoneum in gallbladder cancer","volume":"45","author":"C Maplanka","year":"2014","journal-title":"Journal of gastrointestinal cancer"},{"issue":"05","key":"ref43","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s13244-013-0268-2","article-title":"Clinical impact of FDG PET-CT on management decisions for patients with primary biliary tumours","volume":"4","author":"R Albazaz","year":"2013","journal-title":"Insights into imaging"},{"issue":"11","key":"ref44","first-page":"5105","article-title":"Feasibility of (18)F-fluorodeoxyglucose positron-emission tomography for preoperative evaluation of biliary tract cancer","volume":"32","author":"I Yamada","year":"2012","journal-title":"Anticancer research"},{"issue":"S 07","key":"ref45","doi-asserted-by":"crossref","first-page":"S1489","DOI":"10.21037\/tcr.2016.12.41","article-title":"[(18)F]-choline PET\/CT as an imaging biomarker for primary liver cancers","volume":"5","author":"Z Lee","year":"2016","journal-title":"Transl Cancer Res"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s40336-014-0055-1","article-title":"Use of choline PET for studying hepatocellular carcinoma","volume":"2","author":"J-N Talbot","year":"2014","journal-title":"Clinical and translational imaging"},{"issue":"03","key":"ref47","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2967\/jnumed.118.215913","article-title":"(68)Ga-FAPI PET\/CT: Biodistribution and Preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting Agents in Patients with Various Cancers","volume":"60","author":"F L Giesel","year":"2019","journal-title":"Journal of nuclear medicine: official publication, Society of Nuclear Medicine"},{"issue":"01","key":"ref48","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejrad.2013.05.028","article-title":"Competitive advantage of PET\/MRI","volume":"83","author":"H Jadvar","year":"2014","journal-title":"European journal of radiology"},{"issue":"01","key":"ref49","first-page":"115","article-title":"Quantitative accuracy of attenuation correction in the Philips Ingenuity TF whole-body PET\/MR system: a direct comparison with transmission-based attenuation correction","volume":"26","author":"G Schramm","year":"2013","journal-title":"Magma (New York, NY)"},{"issue":"06","key":"ref50","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s11307-013-0629-8","article-title":"Comparison of standardized uptake values in normal structures between PET\/CT and PET\/MRI in an oncology patient population","volume":"15","author":"S Kershah","year":"2013","journal-title":"Molecular imaging and biology: MIB: the official publication of the Academy of Molecular Imaging"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3174\/ajnr.A3993","article-title":"Qualitative and quantitative performance of (1)(8)F-FDG-PET\/MRI versus (1)(8)F-FDG-PET\/CT in patients with head and neck cancer","volume":"35","author":"S Partovi","year":"2014","journal-title":"AJNR American journal of neuroradiology"}],"container-title":["Nuklearmedizin - NuclearMedicine"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1486-3671.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T17:15:52Z","timestamp":1636391752000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1486-3671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":51,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2021,10,4]]},"published-print":{"date-parts":[[2021,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1486-3671","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0029-5566","2567-6407"],"issn-type":[{"value":"0029-5566","type":"print"},{"value":"2567-6407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,8]]}}}