{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:41:41Z","timestamp":1788306101705,"version":"build-2803163510"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aim\u2002The clinical impact of eosinophilic esophagitis (EoE) limited to the distal esophagus (Lim-EE) vs. diffuse involvement (Dif-EE) is unknown. This study compared clinical characteristics and outcomes of Lim-EE vs. Dif-EE.<\/jats:p><jats:p>\n          Patients and methods\u2002This retrospective, single-center study of patients with EoE between December 2011 and December 2019 evaluated treatment response based on repeated pathology and\/or clinical improvement using comparative statistics.<\/jats:p><jats:p>\n          Results\u2002479 patients were identified (126 Lim-EE, 353 Dif-EE). Lim-EE patients had a higher incidence of endoscopically identified esophagitis (23.0\u200a% vs. 14.7\u200a%; P\u200a=\u200a0.04), were older (50.8 [SD 16.2] vs. 46.4 [SD 15.3] years; P\u200a=\u200a0.007), and were more likely to present with iron deficiency anemia (5.6\u200a% vs. 1.7\u200a%; P\u200a=\u200a0.05), dyspepsia (15.1\u200a% vs. 8.8\u200a%; P\u200a=\u200a0.06) or for Barrett\u2019s surveillance (10.3\u200a% vs. 3.7\u200a%; P\u200a=\u200a0.02). Patients with Dif-EE presented more frequently with dysphagia (57.2\u200a% vs. 45.2\u200a%; P\u200a=\u200a0.02). Both groups had similar proton pump inhibitor (87.2\u200a% vs. 83.3\u200a%; P\u200a=\u200a0.37) and steroid (12.8\u200a% vs. 21.4\u200a%; P\u200a=\u200a0.14) use. Patients with Lim-EE had a better clinicopathologic response (61.5\u200a% vs. 44.8\u200a%; P\u200a=\u200a0.009). On multivariate analysis, EoE extent predicted treatment response with an odds ratio of 1.89 (95\u200a% confidence interval 1.13\u20133.20; P\u200a=\u200a0.02). However, treatment response based only on repeat biopsy results showed no statistical difference between Lim-EE (52.5\u200a%) and Dif-EE (39.7\u200a%; P\u200a=\u200a0.15).<\/jats:p><jats:p>\n          Conclusions\u2002Lim-EE may represent a distinct phenotype separate from Dif-EE, with more overlap with gastroesophageal reflux disease and better treatment response. <\/jats:p>","DOI":"10.1055\/a-1492-2650","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T08:29:22Z","timestamp":1629793762000},"page":"E1234-E1242","source":"Crossref","is-referenced-by-count":6,"title":["Extent of eosinophilic esophagitis predicts response to treatment"],"prefix":"10.1055","volume":"09","author":[{"given":"Hassan","family":"Ghoz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando F.","family":"Stancampiano","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Valery","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Nordelo","sequence":"additional","affiliation":[{"name":"Clinical Research Internship Study Program (CRISP), Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balkishan","family":"Malviya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Lacy","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Francis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"DeVault","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Bouras","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murli","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/j.gastro.2017.06.067","article-title":"Epidemiology and natural history of eosinophilic esophagitis","volume":"154","author":"E S Dellon","year":"2018","journal-title":"Gastroenterology"},{"key":"ref2","first-page":"742","article-title":"Approach to diagnosis of eosinophilic 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