{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:59:28Z","timestamp":1758473968711},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"Medical science research project of\n                    hebei provincial health commission of China","award":["20190030"],"award-info":[{"award-number":["20190030"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of the study is to determine the risks and benefits of treating\n                    idiopathic short stature (ISS) with aromatase inhibitors (AIs). We\n                    comprehensively searched PubMed, Embase, and the China National Knowledge\n                    Infrastructure between establishment year and January 31, 2020. Mean difference\n                    (MD)\/Standardized mean differences (SMD) with 95% confidence\n                    intervals (CI) of individual studies were pooled using fixed or random effects\n                    models. Subgroup and sensitivity analyses were also performed. Publication bias\n                    was estimated using funnel plots and Egger tests. Fourteen studies including 388\n                    participants were included. The meta-analysis results showed that AIs\n                    significantly increased final height (MD=2.46, 95% CI:\n                    0.8\u20134.12) and predicted adult height (MD=0.34, 95% CI:\n                    0.11\u20130.57). Changes in bone age (MD=\u20130.1, 95%\n                    CI: \u20130.86\u20130.66) and bone mineral density\n                    (MD=\u20130.05, 95% CI: \u20130.19\u20130.1) were not\n                    different between intervention and control group. AI significantly increased\n                    testosterone level (SMD=2.01, 95% CI: 0.8\u20133.23) and\n                    reduced estradiol level (SMD=\u20131.13, 95% CI:\n                    \u20131.87 to \u20130.40); The intervention and control group had no\n                    significant differences in the levels of high-density lipoprotein-cholesterol\n                    (SMD=\u20130.31, 95%CI: \u20130.68\u20130.06) and IGF-1\n                    (SMD=0.7, 95% CI: \u20130.66\u20132.06) levels. Adverse\n                    events were more frequent in the intervention group than in the control group\n                    (odds ratio=3.12, 95% CI: 1.44\u20136.73). In conclusion,\n                    both AI monotherapy and AI combination therapy can increase predicted adult\n                    height and testosterone levels.<\/jats:p>","DOI":"10.1055\/a-1492-2841","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T22:33:15Z","timestamp":1624314795000},"page":"391-401","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of Short Stature with Aromatase Inhibitors: A Systematic\n                    Review and Meta-Analysis"],"prefix":"10.1055","volume":"53","author":[{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hebei General Hospital, Shijiazhuang,\n                    Hebei, China"},{"name":"Key Laboratory of Endocrinology of National Health Commission, Chinese\n                    Academy of Medical Science and Peking Union Medical College, Beijing,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujuan","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Chinese\n                    Academy of Medical Science and Peking Union Medical College, Beijing,\n                    China"},{"name":"Graduate School, Hebei North University, Zhangjiakou, Hebei,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyun","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Chinese\n                    Academy of Medical Science and Peking Union Medical College, Beijing,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Chinese\n                    Academy of Medical Science and Peking Union Medical College, Beijing,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Chinese\n                    Academy of Medical Science and Peking Union Medical College, Beijing,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Chinese\n                    Academy of Medical Science and Peking Union Medical College, Beijing,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Chinese\n                    Academy of Medical Science and Peking Union Medical College, Beijing,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Chinese\n                    Academy of Medical Science and Peking Union Medical College, Beijing,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hebei General Hospital, Shijiazhuang,\n                    Hebei, China"},{"name":"Department of Internal Medicine, Hebei Medical University,\n                    Shijiazhuang, Hebei, China"},{"name":"Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital\n                    Shijiazhuang, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"ref1","first-page":"43","article-title":"Evaluation of Short and Tall Stature in Children","volume":"92","author":"C Barstow","year":"2015","journal-title":"Am Fam Physician"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/2042018817707464","article-title":"Etiological factors of short stature in children and adolescents: experience at a\n                tertiary care hospital in Egypt. 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Endocrinol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1002\/jbmr.56","article-title":"Vertebral morphology in aromatase inhibitor-treated males with idiopathic short\n                stature or constitutional delay of puberty","volume":"25","author":"M Hero","year":"2010","journal-title":"J Bone Miner Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fendo.2019.00201","article-title":"Letrozole Monotherapy in Pre- and Early-Pubertal Boys Does Not Increase Adult\n                Height","volume":"10","author":"T Varimo","year":"2019","journal-title":"Front Endocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1515\/jpem-2016-0219","article-title":"Are aromatase inhibitors in boys with predicted short stature and\/or rapidly\n                advancing bone age effective and safe?","volume":"30","author":"J A Ferris","year":"2017","journal-title":"J Pediatr Endocrinol 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Spine-Care J"},{"key":"ref41","first-page":"215","article-title":"Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor\n                drug. Nuclear","volume":"36","author":"K E Kil","year":"2009","journal-title":"Med Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.psyneuen.2010.04.005","article-title":"The influence of high-normal testosterone levels on risk-taking in healthy males in\n                a 1-week letrozole administration study","volume":"35","author":"A E Goudriaan","year":"2010","journal-title":"Psychoneuroendocrinology"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1492-2841.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T22:36:15Z","timestamp":1624314975000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1492-2841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":41,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2021,6,21]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1492-2841","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}