{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T11:11:54Z","timestamp":1675336314190},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n          Diagnostik\u2002Bei Verdacht auf eine Akromegalie wird zun\u00e4chst das Hormon Insulin-like growth factor 1 (IGF-1) als wesentlicher Mediator des Wachstumshormons (GH) bestimmt. Ist es erh\u00f6ht, schlie\u00dft sich eine Best\u00e4tigungsdiagnostik mittels GH-Suppressionstest an. Neue Arbeiten empfehlen f\u00fcr diesen Test niedrigere GH-Grenzwerte als fr\u00fcher, zudem sollen potenzielle Einflussgr\u00f6\u00dfen (z.\u200aB. Body-Mass-Index) st\u00e4rker ber\u00fccksichtigt werden. Perspektivisch k\u00f6nnten Erkrankte mittels einer automatisierten Gesichtserkennung ggf. leichter identifiziert werden.<\/jats:p><jats:p>\n          Komorbidit\u00e4ten\u2002Bei einem unkontrollierten GH-Exzess sind Lebensqualit\u00e4t und -erwartung zum Teil erheblich reduziert. Eine Akromegalie sowie deren typische Folgeerkrankungen (z.\u200aB. Schlafapnoe, Kardiomyopathie, Arthropathie) m\u00fcssen daher fr\u00fchzeitig erkannt werden. K\u00fcrzlich wurden neue Empfehlungen f\u00fcr ein standardisiertes diagnostisches Vorgehen publiziert.<\/jats:p><jats:p>\n          Therapie\u2002Die operative Adenomentfernung durch einen erfahrenen Hypophysenchirurgen ist Therapie der Wahl. Bei residueller Erkrankung kann perspektivisch eine Kombination aus volumetrischer Magnetresonanztomografie (MRT) und 11C-Methionin-Positronen-Emissions-Tomografie (PET) eine Folgeoperation erleichtern. F\u00fcr die typische Zweitlinientherapie mit Somatostatin-Analoga (SSA) ist nun erstmals auch ein oral einzusetzendes Pr\u00e4parat verf\u00fcgbar. Neue Daten belegen die Wirksamkeit und Sicherheit einer Hypophysenbestrahlung.<\/jats:p><jats:p>\n          Spezielle Patientenpopulationen\u2002Schwangere und \u00e4ltere Patienten bed\u00fcrfen besonderer Aufmerksamkeit. Gem\u00e4\u00df aktueller Daten wirkt sich die COVID-Pandemie auch bei einer Akromegalie nachteilig auf Diagnostik und Therapie aus.<\/jats:p>","DOI":"10.1055\/a-1495-2715","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T22:33:09Z","timestamp":1628029989000},"page":"950-954","source":"Crossref","is-referenced-by-count":2,"title":["Neue Entwicklungen und Perspektiven in der Akromegalie"],"prefix":"10.1055","volume":"146","author":[{"given":"Mario","family":"Detomas","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum W\u00fcrzburg, Medizinische Klinik und Poliklinik I, Lehrstuhl f\u00fcr Endokrinologie und Diabetologie, W\u00fcrzburg; Medicover Oldenburg MVZ, Oldenburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Reuter","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum W\u00fcrzburg, Medizinische Klinik und Poliklinik I, Lehrstuhl f\u00fcr Endokrinologie und 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