{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T19:38:19Z","timestamp":1726429099659},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute pancreatitis as an initial manifestation of primary hyperparathyroidism\n                    (PHPT) is a rare occurrence and timely diagnosis of PHPT is crucial in\n                    preventing repeat attack of pancreatitis. The study aimed at evaluating the\n                    clinico-radiological profile of patients admitted with acute pancreatitis as the\n                    index presentation of PHPT and to determine the factors associated with\n                    development of severe pancreatitis. This series included retrospective analysis\n                    of medical records of 30 patients admitted with acute pancreatitis as initial\n                    manifestation of PHPT. Additionally, we analyzed the data of another 30 patients\n                    admitted with PHPT but without any evidence of pancreatitis, to serve as control\n                    group. The mean age of the subjects was 44.9\u00b113.9 years with male to\n                    female ratio of 1.30. The mean serum calcium level was 12.24\u00b12.79\n                    mg\/dl and five (16.6%) patients had normocalcemia at time of\n                    presentation. Presence of nephrolithiasis was significantly associated with\n                    severe pancreatitis. One patient had refractory hypercalcemia associated with\n                    renal failure and was successfully managed with denosumab. Patients with PHPT\n                    associated with acute pancreatitis had significantly higher calcium levels and\n                    lower frequency of skeletal involvement as compared to PHPT patients without\n                    pancreatitis. PHPT masquerading as acute pancreatitis is rare and high index of\n                    suspicion is required to diagnose this condition especially in the presence of\n                    normocalcemia at presentation. Patients with PHPT associated pancreatitis had\n                    male preponderance, higher calcium levels, and lower frequency of skeletal\n                    involvement as compared to PHPT patients without pancreatitis.<\/jats:p>","DOI":"10.1055\/a-1495-5573","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T22:33:15Z","timestamp":1624314795000},"page":"377-381","source":"Crossref","is-referenced-by-count":1,"title":["Primary Hyperparathyroidism Masquerading as Acute\n                    Pancreatitis"],"prefix":"10.1055","volume":"53","author":[{"given":"Saurabh","family":"Arora","sequence":"additional","affiliation":[{"name":"Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parminder","family":"Singh","sequence":"additional","affiliation":[{"name":"Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Verma","sequence":"additional","affiliation":[{"name":"Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Mittal","sequence":"additional","affiliation":[{"name":"Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit","family":"Sood","sequence":"additional","affiliation":[{"name":"Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Kalra","sequence":"additional","affiliation":[{"name":"Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhananjaya","family":"Shanthaiah","sequence":"additional","affiliation":[{"name":"Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0140-6736(01)08363-5","article-title":"Acute fatal hyperparathyroidism","volume":"2","author":"F B Smith","year":"1940","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1210\/jc.2008-1965","article-title":"Acute pancreatitis in primary hyperparathyroidism: A population-based study","volume":"94","author":"T K Khoo","year":"2009","journal-title":"J Clin Endocrinol 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A South Indian experience and a\n                    review of published work","volume":"76","author":"J J Jacob","year":"2006","journal-title":"ANZ J Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"721","DOI":"10.4103\/ijmr.IJMR_353_16","article-title":"Frequency & predictors of pancreatitis in symptomatic primary\n                    hyperparathyroidism","volume":"148","author":"A K Arya","year":"2018","journal-title":"Indian J Med Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1007\/s00268-018-4575-0","article-title":"Changing Profile of Primary Hyperparathyroidism Over Two and Half Decades: A\n                    Study in Tertiary Referral Center of North India","volume":"42","author":"S K Yadav","year":"2018","journal-title":"World J Surg"},{"key":"ref23","first-page":"145","article-title":"Low intracellular magnesium in patients with acute pancreatitis and\n                    hypocalcemia","volume":"152","author":"E Ryzen","year":"1990","journal-title":"West J Med"},{"key":"ref24","first-page":"729","article-title":"The efficacy and safety of intravenous bisphosphonates in the treatment of\n                    primary hyperparathyroidism complicated by hypercalcemia crisis","volume":"48","author":"G Y Han","year":"2009","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000488502","article-title":"The Use of Low-Calcium Hemodialysis in the Treatment of Hypercalcemic\n                    Crisis","volume":"139","author":"S Trabulus","year":"2018","journal-title":"Nephron"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1530\/EC-20-0380","article-title":"Denosumab for management of severe hypercalcemia in primary\n                    hyperparathyroidism","volume":"9","author":"A Eremkina","year":"2020","journal-title":"Endocr Connect"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1495-5573.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T22:34:56Z","timestamp":1624314896000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1495-5573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":26,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2021,6,21]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1495-5573","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"type":"print","value":"0018-5043"},{"type":"electronic","value":"1439-4286"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}