{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:19:31Z","timestamp":1761157171202,"version":"3.37.3"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"10\/11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aleurites moluccanus is used in folk medicine to treat many diseases including pain and inflammatory processes in general. Considering the potential of the leaf extract, evidenced in a previous study, the present study investigates the antinociceptive and anti-inflammatory properties of the hydroethanolic extract of A.\u00a0moluccanus bark and isolated compounds in animal models of pain. The antinociceptive and anti-inflammatory activities of A.\u00a0moluccanus bark were evaluated through hyperalgesia induced by carrageenan, PGE2, cytokines, bradykinin, epinephrine, Freund\u02bcs complete adjuvant, and lipopolysaccharide. Five compounds were isolated from the dichloromethane bark extract: acetyl aleuritolic acid, atraric acid, spruceanol, (5\u03b2,10\u03b1)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one and sonderianol. To optimize the extraction conditions, ethanol 50, 70, and 90\u00b0GL were used as extracting solvent, in a 1\u200a:\u200a20 (w\/v)\n\t\t\t\t\tdrug\u200a:\u200asolvent ratio, under stirring at room temperature for 4\u2009h. The extracts were named AMC50, AMC70, and AMC90, respectively. These extracts were administered to mice (250\u2009mg\/kg, p.\u200ao.) with reduced mechanical hyperalgesia activity in the carrageenan test. Of these, AMC90 showed the best results. Pure (5\u03b2,10\u03b1)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one showed a beneficial effect for up to 48 hours after the administration of carrageenan, while acetyl aleuritolic acid was effective only in the first hour. AMC90 was able to reverse the analgesia induced only by prostaglandin E2 and tumor necrosis factor. We also induced hyperalgesia using the lipopolysaccharide and Freund\u02bcs complete adjuvant models, with positive results. These results support the antinociceptive and anti-inflammatory activity of A.\u00a0moluccanus bark extract. The observed effects are partly due to the presence of acetyl aleuritolic acid, atraric acid, and\n\t\t\t\t\t(5\u03b2,10\u03b1)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one.<\/jats:p>","DOI":"10.1055\/a-1497-0239","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T22:49:21Z","timestamp":1621982961000},"page":"896-906","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemical Analysis and Antinociceptive Properties of Hydroalcoholic Extracts of Aleurites moluccanus Bark"],"prefix":"10.1055","volume":"87","author":[{"given":"M\u00e1rcia Maria","family":"de Souza","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed (UNIVALI), Escola de Ci\u00eancias da Sa\u00fade, Itaja\u00ed, Santa Catarina State, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz G. R. D.","family":"Chagas","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed (UNIVALI), Escola de Ci\u00eancias da Sa\u00fade, Itaja\u00ed, Santa Catarina State, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Elisa","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed (UNIVALI), Escola de Ci\u00eancias da Sa\u00fade, Itaja\u00ed, Santa Catarina State, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Tomczak","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed (UNIVALI), Escola de Ci\u00eancias da Sa\u00fade, Itaja\u00ed, Santa Catarina State, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Reichert","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed (UNIVALI), Escola de Ci\u00eancias da Sa\u00fade, Itaja\u00ed, Santa Catarina State, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivania T. A.","family":"Schuquel","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1 (UEM), Departamento de Qu\u00edmica, Maring\u00e1, Paran\u00e1 State, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdir","family":"Cechinel-Filho","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed (UNIVALI), Escola de Ci\u00eancias da Sa\u00fade, Itaja\u00ed, Santa Catarina State, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-6128","authenticated-orcid":false,"given":"Christiane","family":"Meyre-Silva","sequence":"additional","affiliation":[{"name":"P\u00f3s-gradua\u00e7\u00e3o em Farm\u00e1cia. Universidade Federal de Santa Catarina (UFSC), Bloco JK, Campus Reitor Jo\u00e3o David Ferreira Lima, Trindade, Florian\u00f3polis, Santa Catarina State, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2174\/1381612824666180327165604","article-title":"Signaling pathways in inflammation and anti-inflammatory therapies","volume":"24","author":"Y T Yeung","year":"2018","journal-title":"Curr Pharm Des"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phrs.2018.11.001","article-title":"Molecular pharmacology of inflammation: medicinal plants as anti-inflammatory agents","volume":"139","author":"S Tasneem","year":"2019","journal-title":"Pharmacol Res"},{"volume-title":"Handbook of medicinal Herbs","year":"1991","author":"J A Duke","key":"ref3"},{"volume-title":"Hawaiians of Old. 3th ed","year":"2002","author":"B Dunfors","key":"ref4"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0944-7113(98)80006-8","article-title":"Preliminary phytochemical and pharmacological studies of Aleurites moluccana leaves (L.) 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