{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:01:56Z","timestamp":1790974916228,"version":"4.1.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"LMU Klinikum and Helmholtz Zentrum M\u00fcnchen, Germany, and the German Center for Diabetes Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background The myokine myostatin regulates muscle mass and has been linked to insulin resistance and metabolic syndrome. However, data on its role in humans is still limited. We, therefore, investigated the associations of serum myostatin with muscle mass, physical fitness, and components of the metabolic syndrome in a cohort of premenopausal women.<\/jats:p><jats:p>\n          Methods We undertook a cross-sectional analysis of 233 women from the monocenter study PPSDiab, conducted in Munich, Germany. Participants had recently completed a pregnancy with or without gestational diabetes. Our analysis included medical history, anthropometrics, oral glucose tolerance testing, laboratory chemistry, cardiopulmonary exercise testing, and magnetic resonance imaging (n=142) of visceral fat volume, left quadriceps muscle mass, and muscle fat content. Serum myostatin was quantified by a competitive enzyme-linked immunosorbent assay.<\/jats:p><jats:p>\n          Results We observed positive correlations of serum myostatin with body mass index (\u03c1=0.235; p=0.0003), body fat percentage (\u03c1=0.166; p=0.011), waist circumference (\u03c1=0.206; p=0.002), intraabdominal fat volume (\u03c1=0.182; p=0.030) and high-sensitivity C-reactive protein (\u03c1=0.175; p=0.008). These correlations were reproduced in linear regression analyses with adjustment for age and time after delivery. We saw no correlations with muscle mass, physical fitness, insulin sensitivity, triglycerides, HDL cholesterol, and blood pressure.<\/jats:p><jats:p>\n          Conclusions Our observation of elevated serum myostatin in women with a higher body fat percentage, visceral obesity, and elevated c-reactive protein suggests that this myokine contributes to the altered muscle-adipose tissue crosstalk in metabolic syndrome. Elevated myostatin may advance this pathophysiologic process and could also impair the efficacy of exercise interventions. Further mechanistic studies, therefore, seem warranted.<\/jats:p>","DOI":"10.1055\/a-1500-4605","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T23:31:53Z","timestamp":1629329513000},"page":"393-399","source":"Crossref","is-referenced-by-count":7,"title":["Association of Serum Myostatin with Body Weight, Visceral Fat Volume, and High Sensitivity C-Reactive Protein But Not With Muscle Mass and Physical Fitness in Premenopausal Women"],"prefix":"10.1055","volume":"130","author":[{"given":"Stefanie","family":"Kern-Matschilles","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV, LMU Klinikum, M\u00fcnchen, Germany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Gar","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV, LMU Klinikum, M\u00fcnchen, Germany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Wanger","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Radiologie, LMU Klinikum, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie J.","family":"Haschka","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV, LMU Klinikum, M\u00fcnchen, Germany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Potzel","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV, LMU Klinikum, M\u00fcnchen, Germany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Hesse","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Radiologie, LMU Klinikum, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Then","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV, LMU Klinikum, M\u00fcnchen, Germany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Seissler","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV, LMU Klinikum, M\u00fcnchen, Germany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Lechner","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV, LMU Klinikum, M\u00fcnchen, Germany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research 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