{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T08:49:47Z","timestamp":1651826987222},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Einleitung\u2002Die Diagnosestellung einer seltenen polysymptomatischen Parasitose erfordert eine Zusammenarbeit von Internisten, Tropenmedizinern, Parasitologen und Dermatologen.<\/jats:p><jats:p>\n          Anamnese\u2002Es wird der Krankheitsverlauf einer 66-J\u00e4hrigen mit regelm\u00e4\u00dfigen Aufenthalten in Kamerun aufgezeigt, die sich mit massiver Hypereosinophilie und Pruritus bei urtikariellen Schwellungen pr\u00e4sentierte.<\/jats:p><jats:p>\n          Untersuchungen und Diagnose\u2002Mittels interdisziplin\u00e4rer Diagnostik wurde anhand Reiseanamnese, klinischen Symptomen und Laborergebnissen die Arbeitsdiagnose einer okkulten, amikrofilar\u00e4mischen Loa-loa-Infektion mit immunologischer Hyperreaktion gegen das Parasitenantigen, reaktiver Hypereosinophilie und hoher Anti-Filarien-Antik\u00f6rperkonzentration gestellt.<\/jats:p><jats:p>\n          Therapie und Verlauf\u2002Die anthelminthische Therapie erfolgte mit Ivermectin und Diethylcarbamazin. Unter Ivermectin kam es zur prompten Symptomregredienz und Abfall der Eosinophilen- und Antik\u00f6rperwerte.<\/jats:p><jats:p>\n          Folgerung\u2002Parasitosen wie die L.-loa-Infektion sind in Europa extrem selten, sollten jedoch bei entsprechender Reiseanamnese und klinischem Erscheinungsbild fr\u00fchzeitig als Differenzialdiagnosen beachtet werden. Es mangelt an standardisierten Therapie- und Nachsorgeempfehlungen. Eine pr\u00e4zise Erfassung aller Neudiagnosen mit Therapieverlauf\/-ansprechen in einem internationalen Register sollte etabliert werden.<\/jats:p>","DOI":"10.1055\/a-1500-6375","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T22:33:09Z","timestamp":1628029989000},"page":"1005-1008","source":"Crossref","is-referenced-by-count":1,"title":["Langlebiges Souvenir aus Kamerun \u2013 persistierende, massive Hypereosinophilie bei amikrofilar\u00e4mischer Infektion mit Loa loa"],"prefix":"10.1055","volume":"146","author":[{"given":"Lisa","family":"Meffert","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Bonn, Medizinische Klinik und Poliklinik\u00a0III, Abteilung f\u00fcr Onkologie, H\u00e4matologie und Rheumatologie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Bonn, Medizinische Klinik und Poliklinik\u00a0III, Abteilung f\u00fcr Onkologie, H\u00e4matologie und Rheumatologie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Ziob","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Bonn, Klinik und Poliklinik f\u00fcr Dermatologie und Allergologie"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"issue":"20","key":"ref1","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"D A Arber","year":"2016","journal-title":"Blood"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12879-020-05009-3","article-title":"Mapping lymphatic filariasis in Loa loa endemic health districts na\u00efve for ivermectin mass administration and situated in the forested zone of Cameroon","volume":"20","author":"A A Beng","year":"2020","journal-title":"BMC Infect Dis"},{"issue":"09","key":"ref3","doi-asserted-by":"publisher","first-page":"e649","DOI":"10.1016\/j.ijid.2012.05.1023","article-title":"Imported Loa loa filariasis: three cases and a review of cases reported in non-endemic countries in the past 25 years","volume":"16","author":"S Antinori","year":"2012","journal-title":"Int J Infect Dis"},{"issue":"06","key":"ref4","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.tmaid.2014.07.004","article-title":"Imported loiasis in Italy: an analysis of 100 cases","volume":"12","author":"F Gobbi","year":"2014","journal-title":"Travel Med Infect Dis"},{"issue":"01","key":"ref5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1708-8305.2007.00167.x","article-title":"Diagnostic Problems in a patient with amicrofilaremic Loa loa","volume":"15","author":"M Yoshikawa","year":"2008","journal-title":"J Travel Med"},{"issue":"12","key":"ref6","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1093\/cid\/cix616","article-title":"Macrofilaricidal Efficacy of Repeated Doses of Ivermectin for the Treatment of River Blindness","volume":"65","author":"M Walker","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"04","key":"ref8","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1093\/clinids\/17.4.691","article-title":"Loa loa Infection as a Cause of Migratory Angioedema: Report of Three Cases from the Texas Medical Center","volume":"17","author":"R M Rakita","year":"1993","journal-title":"Clin Infect Dis"},{"issue":"06","key":"ref9","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1093\/infdis\/163.6.1318","article-title":"Loiasis in Endemic and Nonendemic Populations: Immunologically Mediated Differences in Clinical Presentation","volume":"163","author":"A D Klion","year":"1992","journal-title":"J Infect Dis"},{"key":"ref10","first-page":"737","volume-title":"\u201eThe Filariases\u201d, in Manson\u2019s Tropical Diseases","author":"P Simonsen","year":"2014","edition":"23rd ed."}],"container-title":["DMW - 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