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Die individuelle Organsuszeptibilit\u00e4t wird ma\u00dfgeblich durch die Besatzdichte mit dem membranst\u00e4ndigen Rezeptormolek\u00fcl ACE2 bestimmt, das als zentraler Interaktionspartner f\u00fcr das virale Spike-Protein den Adh\u00e4sions- und Fusionsprozess vermittelt und somit die Grundvoraussetzung zur Aufnahme des Virusgenoms in die Wirtszelle schafft. Ausgehend von einem umfangreichen Datensatz klinischer Studien und Fallberichte, gilt es mittlerweile als gesichert, dass auch bestimmte Zellpopulationen des Verdauungstrakts sowie des funktionell angegliederten olfaktorisch-gustatorischen Systems \u00fcber die erforderliche Rezeptorenausstattung verf\u00fcgen und somit durch SARS-CoV-2 \u201eangreifbar\u201c sind. Zahlreiche Berichte \u00fcber gastrointestinale Beschwerden und Laborabnormalit\u00e4ten sind als Indizien f\u00fcr relevante Organdysfunktionen zu werten und untermauern die klinische Bedeutsamkeit einer Mitbeteiligung des Verdauungstrakts im Rahmen einer SARS-CoV-2-Infektion. Organoide sind dreidimensional wachsende In-vitro-Replikate von Organgeweben und nehmen insbesondere dank der organtypisch komplexen zellul\u00e4ren Zusammensetzung und Imitation der physiologischen Funktionsweise von Prim\u00e4rzellen einen hohen Stellenwert f\u00fcr die infektiologische Grundlagenforschung ein. Diese \u00dcbersichtsarbeit befasst sich thematisch mit den pathophysiologischen Aspekten der Infektion verdauungsrelevanter Organe mit SARS-CoV-2 unter besonderer W\u00fcrdigung existierender organoid- oder prim\u00e4rzellkulturbasierter Infektionsmodelle und der daraus hervorgegangenen Erkenntnisse.   <\/jats:p>","DOI":"10.1055\/a-1500-8420","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T23:04:24Z","timestamp":1627340664000},"page":"1205-1213","source":"Crossref","is-referenced-by-count":1,"title":["SARS-CoV-2-Infektion des Verdauungstrakts \u2013 Experimentelle Ans\u00e4tze einer Organoid-basierten in vitro Modellierung"],"prefix":"10.1055","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8117-3023","authenticated-orcid":false,"given":"Viktoria","family":"Hentschel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinik Ulm, Ulm, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-7915","authenticated-orcid":false,"given":"R\u00fcdiger","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr molekulare Virologie, Universit\u00e4tsklinik Ulm, Ulm, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinik Ulm, Ulm, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"M\u00fcnch","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr molekulare Virologie, Universit\u00e4tsklinik Ulm, Ulm, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinik Ulm, Ulm, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kleger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinik Ulm, Ulm, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0140-6736(20)30260-9.","article-title":"Nowcasting and forecasting the potential domestic and international spread\n                    of the 2019-nCoV outbreak originating in Wuhan, China: a modelling\n                    study","volume":"395","author":"JT Wu","year":"2020","journal-title":"Lancet"},{"issue":"13","key":"ref3","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1001\/jama.2020.2648.","article-title":"Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases From the Chinese Center for Disease Control and Prevention","volume":"323","author":"Z Wu","year":"2020","journal-title":"JAMA"},{"issue":"03","key":"ref4","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s12250-020-00212-7.","article-title":"A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility","volume":"35","author":"Q Wang","year":"2020","journal-title":"Virol Sin"},{"issue":"10","key":"ref5","doi-asserted-by":"publisher","first-page":"e105114","DOI":"10.15252\/embj.20105114.","article-title":"SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells","volume":"39","author":"S Lukassen","year":"2020","journal-title":"EMBO J"},{"issue":"05","key":"ref6","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1164\/rccm.202001-0179LE.","article-title":"Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2","volume":"202","author":"Y Zhao","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"issue":"02","key":"ref7","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s11684-020-0754-0.","article-title":"Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection","volume":"14","author":"X Zou","year":"2020","journal-title":"Front Med"},{"issue":"01","key":"ref8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbrc.2020.03.044.","article-title":"Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses","volume":"526","author":"F Qi","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"issue":"05","key":"ref9","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/s41591-020-0868-6.","article-title":"HCA Lung Biological Network. 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