{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:07:38Z","timestamp":1773839258286,"version":"3.50.1"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002We developed a self-propelled capsule endoscope that can be controlled from outside the body with real-time observation. To improve the device, we conducted a clinical trial of total gastrointestinal capsule endoscopy in healthy subjects to ascertain whether our first-generation, self-propelled capsule endoscope was safe and effective for observing the entire human gastrointestinal tract.<\/jats:p><jats:p>\n          Patients and methods\u2002After adequate gastrointestinal pretreatment, five healthy subjects were instructed to swallow a self-propelling capsule endoscope and the safety of a complete gastrointestinal capsule endoscopy with this device was assessed. We also investigated basic problems associated with complete gastrointestinal capsule endoscopy.<\/jats:p><jats:p>\n          Results\u2002No adverse effects of the magnetic field were identified in any of the subjects. No mucosal damage was noted in any of the subjects with the use of our first-generation, self-propelling capsule endoscope. We found that it took longer than expected to observe the stomach; the view was compromised by the swallowed saliva. The pylorus was extremely difficult to navigate, and the endoscope\u2019s fin sometimes got caught in the folds of the small intestine and colon.<\/jats:p><jats:p>\n          Conclusions\u2002To resolve the problems associated with the existing self-propelling capsule endoscope, it may be necessary to not only improve the capsule endoscopes, but also to control the environment within the gastrointestinal tract with medications and other means. Our results could guide other researchers in developing capsule endoscopes controllable from outside the body, thus allowing real-time observation.<\/jats:p>","DOI":"10.1055\/a-1507-4540","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T23:08:19Z","timestamp":1629760099000},"page":"E1391-E1396","source":"Crossref","is-referenced-by-count":5,"title":["Safety, efficacy, and maneuverability of a self-propelled capsule endoscope for observation of the human gastrointestinal tract"],"prefix":"10.1055","volume":"09","author":[{"given":"Kazuhiro","family":"Ota","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Kojima","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Kakimoto","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadaharu","family":"Nouda","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Shindo","sequence":"additional","affiliation":[{"name":"Mu Ltd., Seta, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitake","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Mu Ltd., Seta, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotake","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Mu Ltd., Seta, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.gie.2010.06.016","article-title":"In vivo trial of a driving system for a self-propelling capsule endoscope using a magnetic field (with video)","volume":"72","author":"E Morita","year":"2010","journal-title":"Gastrointest Endosc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e0139878","DOI":"10.1371\/journal.pone.0139878","article-title":"What kind of capsule endoscope is suitable for a controllable self-propelling capsule endoscope? Experimental study using a porcine stomach model for clinical application (with videos)","volume":"10","author":"K Ota","year":"2015","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/den.12969","article-title":"Retrograde colon capsule endoscopy with the self-propelling capsule endoscope: The first human trial (with videos)","volume":"30","author":"S Nouda","year":"2018","journal-title":"Dig Endosc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"AB126","DOI":"10.1016\/j.gie.2012.04.025","article-title":"Observation of whole digestive tract of a human by a single passage of a self-propelling capsule endoscope","volume":"75","author":"N Ohtsuka","year":"2012","journal-title":"Gastrointest Endosc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.gie.2011.09.030","article-title":"Blinded nonrandomized comparative study of gastric examination with a magnetically guided capsule endoscope and standard videoendoscope","volume":"75","author":"J F Rey","year":"2012","journal-title":"Gastrointest Endosc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12876-019-1101-2","article-title":"Human gastric magnet-controlled capsule endoscopy conducted in a standing position: the phase 1 study","volume":"19","author":"C S Cheng","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1055\/s-0034-1391123","article-title":"Magnetic-controlled capsule endoscopy vs. gastroscopy for gastric diseases: a two-center self-controlled comparative trial","volume":"47","author":"W B Zou","year":"2015","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.dld.2018.04.013","article-title":"Preliminary study of magnetically controlled capsule gastroscopy for diagnosing superficial gastric neoplasia","volume":"50","author":"Y Y Qian","year":"2018","journal-title":"Dig Liver Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1023\/A:1012374408853","article-title":"Pyloric relaxation regulated via intramural neural pathway of the antrum","volume":"46","author":"E Mochiki","year":"2001","journal-title":"Dig Dis Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejphar.2016.03.047","article-title":"Effects of Buscopan on human gastrointestinal smooth muscle activity in an ex vivo model: Are there any differences for various sections?","volume":"780","author":"L Zhang","year":"2016","journal-title":"Eur J Pharmacol"}],"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1507-4540.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T23:08:38Z","timestamp":1629760118000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1507-4540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,23]]},"references-count":10,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2021,8,16]]},"published-print":{"date-parts":[[2021,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1507-4540","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,23]]}}}