{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:09:22Z","timestamp":1782166162965,"version":"3.54.5"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Despite its vast spectrum of clinical usage, cyclophosphamide\n                    (CP) exerts many adverse impacts, including hepatotoxicity. Antioxidant\n                    properties of ghrelin might protect the liver from CP-induced toxicity. The\n                    current study aimed to assess the protective impacts of ghrelin on CP-induced\n                    liver toxicity.<\/jats:p><jats:p>\n          Methods Forty male mice were randomly divided into four groups\n                    (n=10) Group 1 as control received no intervention,group 2 received\n                    cyclophosphamide (CP) (100\u2009mg\/kg, i.p.) for five weeks and once\n                    a week. Group 3 received CP+ghrelin (CP+G),\n                    (80\u2009\u00b5g\/kg daily, i.p.) for five weeks. Group 4 received\n                    ghrelin with above-mentioned dose. At the end of the experiment, the mice were\n                    sacrificed to remove liver tissuesfor histological and biochemical\n                    examination.<\/jats:p><jats:p>\n          Results Malondialdehyde (MDA) level increased after CP treatment but\n                    ghrelin administration significantly decreased the level of MDA\n                    (P&lt;0.05). Measurement of the total antioxidant capacity (TAC) noted a\n                    significant decrease in the CP group against the control group (P&lt;0.05).\n                    Ghrelin treatment in the CP+G group considerably increased the TAC\n                    activity when compared to the CP group (P&lt;0.05). Histological\n                    examinations also confirmed the hepatocyte necrosis, local bleeding and\n                    inflammation, vacuolation, and sinusoidal dilation in the CP group, ghrelin\n                    administration reduced the destructive effects of CP on the liver significantly\n                    (P&lt;0.05).<\/jats:p><jats:p>\n          Conclusion Our results reveal the hepatoprotective effect of ghrelin\n                    against CP. Therefore, ghrelin might be useful in protecting the body against\n                    the adverse impacts of injuries induced by chemotherapeutic drugs.<\/jats:p>","DOI":"10.1055\/a-1508-5368","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:58:41Z","timestamp":1626742721000},"page":"407-412","source":"Crossref","is-referenced-by-count":7,"title":["Hepatoprotective Impact of Ghrelin against Cyclophosphamide-Induced\n                    Toxicity in the Male Mice"],"prefix":"10.1055","volume":"71","author":[{"given":"Elnaz","family":"Khordad","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Paramedical Sciences, Torbat\n                    Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran"},{"name":"Neuroscience Research Center, Torbat Heydariyeh University of Medical\n                    Sciences, Torbat Heydariyeh, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Alipour","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cellular Biology, School of Medicine, Mashhad\n                    University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh","family":"Pourabbas","sequence":"additional","affiliation":[{"name":"Student Research Committee, Torbat Heydariyeh University of Medical\n                    Sciences, Torbat Heydariyeh, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somaieh","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, North Khorasan University\n                    of Medical Sciences, Bojnurd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Salimnejad","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences and Pathology, School of Medicine,\n                    Ardabil University of Medical Sciences, Ardabil, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"ref1","first-page":"527","article-title":"Cancer death rates--Appalachia, 1994-1998","volume":"51","year":"2002","journal-title":"MMWR Morbidity and Mortality Weekly Report"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrclinonc.2009.146","article-title":"Cyclophosphamide and cancer: golden anniversary","volume":"6","author":"A Emadi","year":"2009","journal-title":"Nature reviews Clinical Oncology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e12883","DOI":"10.1111\/and.12883","article-title":"Effect of ghrelin on total antioxidant capacity, lipid peroxidation, sperm\n                    parameters and fertility in mice against oxidative damage caused by\n                    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