{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:28Z","timestamp":1740126808484,"version":"3.37.3"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"name":"Certificate of China Postdoctoral\n                    Science Foundation","award":["2019M651970"],"award-info":[{"award-number":["2019M651970"]}]},{"name":"Natural Science\n                        Foundation of the Jiangsu Higher Education Institution of China","award":["17KJD310005"],"award-info":[{"award-number":["17KJD310005"]}]},{"name":"Jiangsu Province graduate student innovation\n                        project","award":["KYCX19-2214"],"award-info":[{"award-number":["KYCX19-2214"]}]},{"name":"Xuzhou medical university research\n                        project","award":["2017KJ03"],"award-info":[{"award-number":["2017KJ03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thyrotropin receptor antibodies (TRAbs) play a significant role in the course of\n                    hepatic dysfunction (HDF) in patients with Graves\u2019 disease (GD).\n                    However, few studies have considered the factors that influence the\n                    relationships among TRAbs, thyroid hormone levels, and hepatic function in\n                    subjects with newly diagnosed GD. Here we investigated the associations of TRAbs\n                    with thyroid hormones and hepatic function and assessed potential factors that\n                    can influence these associations among patients with GD. A total of 368 patients\n                    newly diagnosed with GD were collected in this cross-sectional study. Patients\n                    who had received antithyroid drugs, radioactive iodine, or surgery were\n                    excluded. Levels of TRAbs and thyroid hormones and hepatic function were\n                    recorded. Linear and binary logistic regression analysis models were applied to\n                    investigate associations among these variables after adjusting for confounding\n                    characteristics. There was a significant difference in TRAbs indices between the\n                    HDF and normal hepatic function groups (p &lt;0.05). After adjusting for\n                    confounders, the relationship between TRAbs and thyroid hormones was nonlinear,\n                    showing a curve with an initial positive slope and a subsequent flattening (p\n                    &lt;0.05). Higher TRAbs were associated with HDF [odds ratio (OR) 1.036,\n                    95% confidence interval (CI) 1.018\u20131.053 per 1-IU\/l\n                    increase]. These associations were modified by age, but not by gender, smoking\n                    status, Graves\u2019 orbitopathy, thyroid-peroxidase antibody levels, or\n                    thyroglobulin antibody levels. In younger patients, increasing TRAbs were\n                    correlated with higher thyroid hormones and HDF (OR 1.034, 95% CI\n                    1.017\u20131.052) per1-IU\/l increase). In older patients, TRAbs were\n                    not correlated with thyroid hormones or HDF (OR 1.024, 95% CI\n                    0.993\u20131.056) per 1-IU\/l increase. Age can affect the impact of\n                    TRAbs on thyroid hormone levels and hepatic function in GD. TRAb measurement can\n                    have good predictive value in younger patients.<\/jats:p>","DOI":"10.1055\/a-1510-9100","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:16:56Z","timestamp":1626740216000},"page":"453-460","source":"Crossref","is-referenced-by-count":1,"title":["Age Moderates the Impact of TRAbs on Thyroid Hormones and Hepatic\n                    Function in Patients with Graves\u2019 Disease"],"prefix":"10.1055","volume":"53","author":[{"given":"Kai","family":"Guo","sequence":"first","affiliation":[{"name":"The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Xuzhou Medical\n                    University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0224-0265","authenticated-orcid":false,"given":"Changjiang","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Xuzhou Medical\n                    University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1210\/jc.2013-2409","article-title":"The incidence and prevalence of thyroid dysfunction in Europe: A\n                    meta-analysis","volume":"99","author":"A Garmendia Madariaga","year":"2014","journal-title":"J 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