{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:18:33Z","timestamp":1791890313867,"version":"4.3.4"},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anabolic androgenic steroid (AAS) abuse leads to myocardial toxicity. Human studies are conflicting about the myocardial fibrosis in AAS users. We evaluated cardiac tissue characterization, left ventricle (LV) function, and cardiac structure by cardiovascular magnetic resonance (CMR). Twenty strength-trained AAS users (AASU) aged 29\u00b15\u2009yr, 20 strength-trained AAS nonusers (AASNU), and 7 sedentary controls (SC) were enrolled. Native T1 mapping, late-gadolinium enhancement (LGE), extracellular volume (ECV), and myocardial strain were evaluated. AASU showed lower Native T1 values than AASNU (888\u00b1162 vs. 1020\u00b1179\u2009ms p=0.047). Focal myocardial fibrosis was found in 2 AASU. AASU showed lower LV radial strain (30\u00b18 vs. 38\u00b16%, p&lt;0.01), LV circumferential strain (\u201317\u00b13 vs. \u221220\u00b12%, p&lt;0.01), and LV global longitudinal strain (\u201317\u00b13 vs. \u201320\u00b13%, p&lt;0.01) than AASNU by CMR. By echocardiography, AASU demonstrated lower 4-chamber longitudinal strain than AASNU (\u201315\u00b1g3 vs. \u201318\u00b12%, p=0.03). ECV was similar among AASU, AASNU, and SC (28\u00b110 vs. 28\u00b17 vs. 30\u00b17%, p=0.93). AASU had higher LV mass index than AASNU and SC (85\u00b114 vs. 64\u00b18 vs. 58\u00b15\u2009g\/m2, respectively, p&lt;0.01). AAS abuse may be linked to decreased myocardial native T1 values, impaired myocardial contractility, and focal fibrosis. These alterations may be associated with maladaptive cardiac hypertrophy in young AAS users.<\/jats:p>","DOI":"10.1055\/a-1518-7953","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:05:54Z","timestamp":1627949154000},"page":"183-191","source":"Crossref","is-referenced-by-count":3,"title":["Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users"],"prefix":"10.1055","volume":"43","author":[{"given":"Francis Ribeiro","family":"de Souza","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Rodrigues","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Rochitte","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Parenquine","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Paix\u00e3o","family":"Jord\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivanhoe Stuart","family":"Leite","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Wesley Peixoto","family":"da Fonseca","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Almeida","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Franco","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Farmacoci\u00eancias da Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio","family":"Yonamine","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas da Faculdade de Ci\u00eancias Farmac\u00eauticas da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria Rodrigues","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Metabolismo \u00d3sseo, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Negr\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Escola de Educa\u00e7\u00e3o F\u00edsica e Esporte da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"de Nazar\u00e9 Nunes Maria Janieire","family":"Alves","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0026-0495(85)90196-9","article-title":"The effect of anabolic steroids on lean body mass: the dose response 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