{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:05:21Z","timestamp":1781715921413,"version":"3.54.5"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                    Objective Meat and eggs from chickens infected with Salmonella Enteritidis, Salmonella Typhimurium and Salmonella Infantis are considered to be an important source of Salmonella infections for humans. In order to control Salmonella infections in chickens, basic biosecurity measures are taken in combination with inactivated or attenuated live vaccines. Apart from an adaptive immune response, some live vaccines also induce innate immune mechanisms that prevent or inhibit systemic invasion with homologous Salmonella serovars. It is unknown whether these invasion inhibition effects are also directed against heterologous Salmonella serovars. Furthermore, it is unclear whether the adaptive immune response after vaccination with a Salmonella Enteritidis phage type\u20054 live vaccine is also directed against other phage types of Salmonella Enteritidis and Typhimurium.<\/jats:p><jats:p>\n                    Material and methods Specific pathogen-free day-old chicks were vaccinated orally with a commercially available Salmonella Enteritidis live vaccine. To test the invasion inhibition effect, the animals were challenged orally with a labelled Salmonella Typhimurium or Salmonella Infantis strain 1\u2005day after vaccination. To demonstrate the adaptive immune response against non-phage type\u20054\u2005Salmonella Enteritidis strains and a monophasic Salmonella Typhimurium strain, the chickens were challenged with Salmonella Enteritidis strains of phage types 1, 8 and 21 and a monophasic Salmonella Typhimurium strain (Definitive Type\u2005193). After challenge, the abundance of the challenge strain in liver and cecal tissue was enumerated and compared with a corresponding control group.<\/jats:p><jats:p>\n                    Results Findings showed that the live Salmonella Enteritidis vaccine inhibits systemic invasion after early infection with Salmonella Typhimurium and Salmonella Infantis. Furthermore, adaptive immunity against the tested non-phage type\u20054\u2005Salmonella Enteritidis strains and the monophasic Salmonella Typhimurium strain was demonstrated.<\/jats:p><jats:p>\n                    Conclusion and clinical relevance The results of this study demonstrate that vaccination with the Salmonella Enteritidis phage type\u20054 live vaccine significantly inhibits the invasion of Salmonella Typhimurium and Infantis. Furthermore, an adaptive immune response was also detected against non-phage type\u20054\u2005Salmonella Enteritidis strains and a monophasic Salmonella Typhimurium strain.<\/jats:p>","DOI":"10.1055\/a-1520-1369","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T22:33:51Z","timestamp":1629758031000},"page":"249-255","source":"Crossref","is-referenced-by-count":6,"title":["Invasion inhibition effects and immunogenicity after vaccination of SPF chicks with a Salmonella Enteritidis live vaccine"],"prefix":"10.1055","volume":"49","author":[{"given":"Sven","family":"Springer","sequence":"additional","affiliation":[{"name":"Ceva Innovation Center GmbH, Dessau-Ro\u00dflau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Theu\u00df","sequence":"additional","affiliation":[{"name":"Ceva Innovation Center GmbH, Dessau-Ro\u00dflau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"Toth","sequence":"additional","affiliation":[{"name":"Ceva Phylaxia Veterinary Biologicals co. Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Szogyenyi","sequence":"additional","affiliation":[{"name":"Ceva Phylaxia Veterinary Biologicals co. Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"publisher","first-page":"5926","DOI":"10.2903\/j.efsa.2019.5926","article-title":"The European Union One Health 2018 Zoonoses Report","volume":"17","author":"Anonymous","year":"2019","journal-title":"EFSA Journal"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1017\/S095026880700920X","article-title":"Drastic decrease of Salmonella Enteritidis isolated from humans in Belgium in 2005, shift in phage types and influence on foodborne outbreaks","volume":"136","author":"J M Collard","year":"2008","journal-title":"Epidemiol Infect"},{"issue":"08","key":"ref3","doi-asserted-by":"publisher","first-page":"e000070","DOI":"10.1099\/mgen.0.000070","article-title":"Phylogenetic structure of European Salmonella Enteritidis outbreak correlates with national and international egg distribution network","volume":"2","author":"T Dallman","year":"2016","journal-title":"Microb Genom"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1017\/S1466252300000050","article-title":"Vaccination against the avian enteropathogens Eimeria, Cryptosporidium and Salmonella","volume":"1","author":"E P Lillehoj","year":"2000","journal-title":"Anim Health Res Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.rvsc.2016.05.001","article-title":"Combination of competitive exclusion and immunisation with a live Salmonella vaccine in newly hatched chickens: Immunological and microbiological effects","volume":"107","author":"M Braukmann","year":"2016","journal-title":"Res Vet Sci"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1128\/iai.62.11.4739-4746.1994","article-title":"Invasiveness and persistence of Salmonella enteritidis, Salmonella typhimurium, and a genetically defined S. enteritidis aroA strain in young chickens","volume":"62","author":"G L Cooper","year":"1994","journal-title":"Infect Immun"},{"issue":"21","key":"ref7","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1016\/j.vaccine.2018.04.041","article-title":"Immunisation of chickens with live Salmonella vaccines \u2013 Role of booster vaccination","volume":"36","author":"U Methner","year":"2018","journal-title":"Vaccine"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1128\/iai.64.3.938-944.1996","article-title":"Effect of vaccination of hens with an avirulent strain of Salmonella typhimurium on immunity of progeny challenged with wild-Type Salmonella strains","volume":"64","author":"J O Hassan","year":"1996","journal-title":"Infect Immun"},{"key":"ref9","first-page":"89","article-title":"Duration of immunity induced in chickens by an attenuated live Salmonella enteritidis vaccine and an inactivated Salmonella enteritidis\/typhimurium vaccine","volume":"124","author":"S Springer","year":"2011","journal-title":"Berl Munch Tierarztl Wochenschr"},{"issue":"12","key":"ref10","doi-asserted-by":"publisher","first-page":"e01070","DOI":"10.1016\/j.heliyon.2018.e01070","article-title":"Demonstration of the efficacy of a Salmonella Enteritidis live vaccine for chickens according to the current European Pharmacopoeia Monograph","volume":"4","author":"T Theu\u00df","year":"2018","journal-title":"Heliyon"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijmm.2010.02.001","article-title":"Characterisation of multidrug resistant Salmonella Typhimurium 4,[5],12:i- DT193 strain carrying a novel genomic island adjacent to the thrW tRNA locus","volume":"300","author":"S Tr\u00fcpschuch","year":"2010","journal-title":"Int J Med Microbiol Suppl"},{"issue":"06","key":"ref12","first-page":"225","article-title":"Model for experimental efficacy testing of control measures against Salmonella infections in poultry","volume":"102","author":"U Methner","year":"1995","journal-title":"Dtsch Tierarztl Wochenschr"},{"key":"ref13","first-page":"86","volume-title":"Salmonella Virulence Mechanisms and their Genetic Basis","author":"T Sterzenbach","year":"2013"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.vetmic.2018.03.022","article-title":"Oral vaccination with a live Salmonella Enteritidis\/Typhimurium bivalent vaccine in layers induces cross-protection against cecal and internal organ colonization by a Salmonella Infantis strain","volume":"218","author":"V Eeckhaut","year":"2018","journal-title":"Vet Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1016\/j.vaccine.2010.08.050","article-title":"Induction of a homologous and heterologous invasion-inhibition effect after administration of Salmonella strains to newly hatched chicks","volume":"28","author":"U Methner","year":"2010","journal-title":"Vaccine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1863-2378.2011.01400.x","article-title":"Exploitation of intestinal colonization-inhibition between salmonella organisms for live vaccines in poultry \u2013 potential and limitations","volume":"58","author":"U Methner","year":"2011","journal-title":"Zoonoses Public Health"},{"issue":"10","key":"ref17","first-page":"369","article-title":"Immunization with potential Salmonella enteritidis mutants \u2013 2. Investigations on the attenuation and immunogenicity for mice and young hens","volume":"109","author":"G Martin","year":"1996","journal-title":"Berl Munch Tierarztl Wochenschr"},{"issue":"06","key":"ref18","first-page":"246","article-title":"A new live Salmonella enteritidis vaccine for chickens \u2013 experimental evidence of its safety and efficacy","volume":"113","author":"S Springer","year":"2000","journal-title":"Berl Munch Tierarztl Wochenschr"},{"issue":"17","key":"ref19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/vr.165.17.493","article-title":"Salmonella colonization of laying hens following vaccination with killed and live attenuated commercial Salmonella vaccines","volume":"165","author":"R J Atterbury","year":"2009","journal-title":"Vet Rec"},{"key":"ref20","first-page":"16","article-title":"Cross-protection against Salmonella Typhimurium infection conferred by a live attenuated Salmonella Enteritidis vaccine","volume":"79","author":"R M Nandre","year":"2015","journal-title":"Can J Vet Res"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/03079457.2014.896990","article-title":"Estimation of the impact of vaccination on faecal shedding and organ and egg contamination for Salmonella Enteritidis, Salmonella Typhimurium and monophasic Salmonella Typhimurium","volume":"43","author":"E Arnold","year":"2014","journal-title":"Avian Pathol"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1637\/10997-120214-Reg","article-title":"Risk factors associated with Salmonella in laying hen farms: systematic review of observational studies","volume":"59","author":"T Denagamage","year":"2015","journal-title":"Avian Dis"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe G: Gro\u00dftiere \/ Nutztiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1520-1369.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T22:34:23Z","timestamp":1629758063000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1520-1369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":22,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2021,8,23]]},"published-print":{"date-parts":[[2021,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1520-1369","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1220","2567-5834"],"issn-type":[{"value":"1434-1220","type":"print"},{"value":"2567-5834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]}}}