{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:12:55Z","timestamp":1785539575764,"version":"3.56.0"},"reference-count":85,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>\n            Background\u2002Since its outbreak in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has\u00a0infected more than 151 million people worldwide. More than 3.1 million have died from Coronavirus Disease 2019 (COVID-19), the illness caused by SARS-CoV-2. The virus affects mainly the upper respiratory tract and the lungs causing pneumonias of varying severity. Moreover, via direct and indirect pathogenetic mechanisms, SARS-CoV-2 may lead to a variety of extrapulmonary as well as vascular manifestations.<\/jats:p><jats:p>\n            Methods\u2002Based on a systematic literature search via PubMed, original research articles, meta-analyses, reviews, and case reports representing the current scientific knowledge regarding diagnostic imaging of COVID-19 were selected. Focusing on the imaging appearance of pulmonary and extrapulmonary manifestations as well as indications for imaging, these data were summarized in the present review article and correlated with basic pathophysiologic mechanisms.<\/jats:p><jats:p>\n            Results and Conclusion\u2002Typical signs of COVID-19 pneumonia are multifocal, mostly bilateral, rounded, polycyclic or geographic ground-glass opacities and\/or consolidations with mainly peripheral distribution. In severe cases, peribronchovascular lung zones are affected as well. Other typical signs are the \u201ccrazy paving\u201d pattern and the halo and reversed halo (the latter two being less common). Venous thromboembolism (and pulmonary embolism in particular) is the most frequent vascular complication of COVID-19. However, arterial thromboembolic events like ischemic strokes, myocardial infarctions, and systemic arterial emboli also occur at higher rates. The most frequent extrapulmonary organ manifestations of COVID-19 affect the central nervous system, the heart, the hepatobiliary system, and the gastrointestinal tract. Usually, they can be visualized in imaging studies as well. The most important imaging modality for COVID-19 is chest CT. Its main purpose is not to make the primary diagnosis, but to differentiate COVID-19 from other (pulmonary) pathologies, to estimate disease severity, and to detect concomitant diseases and complications.<\/jats:p><jats:p>\n            Key Points:\u2002<\/jats:p><jats:p>\n            Citation Format\n          <\/jats:p>","DOI":"10.1055\/a-1522-3155","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T22:50:53Z","timestamp":1634251853000},"page":"141-151","source":"Crossref","is-referenced-by-count":4,"title":["One year of COVID-19 pandemic: what we Radiologists have learned about imaging"],"prefix":"10.1055","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-5830","authenticated-orcid":false,"given":"Alexander","family":"Gross","sequence":"additional","affiliation":[{"name":"Radiology and Interventional Therapy, Vivantes-Klinikum Neuk\u00f6lln, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Radiology and Interventional Therapy, Vivantes-Klinikum Neuk\u00f6lln, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"ref3","doi-asserted-by":"publisher","first-page":"m3862","DOI":"10.1136\/bmj.m3862","article-title":"Virology, transmission, and pathogenesis of SARS-CoV-2","volume":"371","author":"M Cevik","year":"2020","journal-title":"BMJ"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJMc2004973","article-title":"Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1","volume":"382","author":"N van Doremalen","year":"2020","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1002\/jmv.25884","article-title":"Clinical 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