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The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intrahepatic cholestasis should always be managed in a perinatal centre with close interdisciplinary monitoring and treatment involving perinatologists and hepatologists to minimise the markedly increased perinatal morbidity and mortality as well as maternal symptoms.<\/jats:p>","DOI":"10.1055\/a-1522-5178","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:01:34Z","timestamp":1628553694000},"page":"940-947","source":"Crossref","is-referenced-by-count":14,"title":["Intrahepatic Cholestasis of Pregnancy"],"prefix":"10.1055","volume":"81","author":[{"given":"Stanis\u0142aw M.","family":"Jurk","sequence":"additional","affiliation":[{"name":"Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas E.","family":"Kremer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1, Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"},{"name":"Klinik f\u00fcr Gastroenterologie und 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