{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:47:28Z","timestamp":1790189248475,"version":"4.1.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Aim Our goal was to assess visual and quantitative aspects of multimodal skeletal SPECT\/CT reconstructions (recon) in differentiating necrotic and healthy bone of patients with suspected MRONJ.<\/jats:p><jats:p>\n               Methods Prior to surgery, 20 patients with suspected MRONJ underwent SPECT\/CT of the jaw 3\u20134 hours after injection of Tc-99m-DPD (622\u00b1112.4 MBq). SPECT\/CT data were reconstructed using the multimodal xSPECT Bone and xSPECT Quant algorithms as well as the OSEM-algorithm FLASH 3D. For analysis, we divided the jaw into 12 separate regions. Both xSPECT Bone and FLASH 3D datasets were scored on a four-point scale (VIS xSPECT; VIS F3D), based on the intensity of localized tracer uptake. In F3D and xSPECT Quant datasets, local tracer uptake of each region was recorded as semi-quantitative uptake ratio (SQR F3D) or SUVs, respectively. ROC analysis was performed. Postoperative histologic results served as gold standard.<\/jats:p><jats:p>\n               Results VIS F3D, VIS xSPECT and SQR F3D did not differ significantly in diagnostic accuracy (VIS xSPECT sensitivity=0.64; specificity=0.89). Of the quantitative parameters, SUVpeak yielded the best interobserver reproducibility. SUVpeak was 9.9\u00b17.1 (95%CI: 7.84\u201311.95) in MRONJ regions, as opposed 3.6\u00b11.8 (95% CI:3.36\u20133.88) elsewhere, with a cutpoint of 4.5 (sensitivity=0.83; specificity=0.80). Absolute quantitation significantly surpassed VIS and SQR (p&lt;0.05) in accuracy and interobserver agreement (SUVpeak: \u03ba=0.92; VIS xSPECT: \u03ba=0.61; SQR F3D \u03ba=0.66).<\/jats:p><jats:p>\n               Conclusion Absolute quantitation proved significantly more accurate than visual and semi-quantitative assessment in diagnosing MRONJ, with higher interobserver agreement.<\/jats:p>","DOI":"10.1055\/a-1525-7621","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T01:37:38Z","timestamp":1637804258000},"page":"403-410","source":"Crossref","is-referenced-by-count":3,"title":["Quantitative Analysis of Multimodal Skeletal SPECT\/CT Reconstructions in Diagnosing Medication-related Osteonecrosis of the Jaw"],"prefix":"10.1055","volume":"60","author":[{"given":"Michael Thomas","family":"Beck","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen Nuklearmedizinische Klinik, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Rugel","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen Nuklearmedizinische Klinik, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Reinfelder","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen Nuklearmedizinische Klinik, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Kuwert","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen Nuklearmedizinische Klinik, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Ritt","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen Nuklearmedizinische Klinik, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kreissel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Mund- Kiefer- und Gesichtschirurgie, Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Schlittenbauer","sequence":"additional","affiliation":[{"name":"Abteilung Mund- Kiefer- und Gesichtschirurgie, Universit\u00e4tsklinikum Augsburg, Augsburg, Germany"},{"name":"Klinik f\u00fcr Mund- Kiefer- und Gesichtschirurgie, Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and 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A prospective comparison of 200 scans","volume":"2","author":"I Duncan","year":"2018","journal-title":"Eur J Hybrid Imaging"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13550-018-0367-7","article-title":"A new SPECT\/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases","volume":"8","author":"O Delcroix","year":"2018","journal-title":"EJNMMI research"}],"container-title":["Nuklearmedizin - NuclearMedicine"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1525-7621.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T14:28:42Z","timestamp":1639578522000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1525-7621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":32,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2021,11,24]]},"published-print":{"date-parts":[[2021,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1525-7621","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0029-5566","2567-6407"],"issn-type":[{"value":"0029-5566","type":"print"},{"value":"2567-6407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]}}}