{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:47:31Z","timestamp":1770140851625,"version":"3.49.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2002Prenatal prediction of postnatal univentricular versus biventricular circulation in patients with borderline left ventricle (bLV) remains challenging. This study investigated prenatal fetal echocardiographic parameters and postnatal outcome of patients with a prenatally diagnosed bLV.<\/jats:p><jats:p>\n          Methods\u2002We report a retrospective study of bLV patients at four prenatal centers with a follow-up of one year. BLV was defined as z-scores of the left ventricle (LV) between \u20132 and \u20134. Single-ventricle palliation (SVP), biventricular repair (BVR), and no surgical or catheter-based intervention served as the dependent outcome. Prenatal ultrasound parameters were used as independent variables. Cut-off values from receiver operating characteristic curves (ROC) were determined for significant discrimination between outcomes.<\/jats:p><jats:p>\n          Results\u2002A total of 54 patients were diagnosed with bLV from 2010 to 2018. All were live births. Out of the entire cohort, 8\u00a0(15\u200a%) received SVP, 34 (63\u200a%) BVR, and 12 (22\u200a%) no intervention. There was no significant difference with regard to genetic or extracardiac anomalies. There were significantly more patients with endocardial fibroelastosis (EFE) in the SVP group compared to the BVR group (80\u200a% vs. 10\u200a%), (p\u200a&lt;\u200a0.001). Apex-forming LV (100\u200a% vs. 70\u200a%) and lack of retrograde arch flow (20\u200a% vs. 80\u200a%) were associated with no intervention (p\u200a&lt;\u200a0.001). With respect to BVR vs. SVP, the LV sphericity index provided the highest specificity (91.7\u200a%) using a cutoff value of \u2264\u200a0.5.<\/jats:p><jats:p>\n          Conclusion\u2002The majority of bLV patients maintained biventricular circulation. EFE, retrograde arch flow, and LV sphericity can be helpful parameters for counseling parents and further prospective studies can be developed.<\/jats:p>","DOI":"10.1055\/a-1530-5240","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T23:43:07Z","timestamp":1625528587000},"page":"e62-e71","source":"Crossref","is-referenced-by-count":5,"title":["Fetal Echocardiography in Predicting Postnatal Outcome in Borderline Left Ventricle"],"prefix":"10.1055","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7499-8115","authenticated-orcid":false,"given":"Carina Nina","family":"Vorisek","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus Liebig University and UKGM, Giessen, Germany"},{"name":"Core-Unit eHealth and Interoperability, Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Bischofsberger","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus Liebig University and UKGM, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrii","family":"Kurkevych","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit, Ukrainian Children's Hospital, Kyiv, UA, Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uygar","family":"Y\u00fcr\u00f6k\u00fcr","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Justus Liebig University and UKGM, Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Wolter","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus Liebig University and UKGM, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Gembruch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Hudel","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Justus Liebig University, Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Thul","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Justus Liebig University and UKGM, Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jux","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Justus Liebig University and UKGM, Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Akint\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Justus Liebig University and UKGM, Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Schranz","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center, Johann Wolfgang Goethe University Clinic, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Axt-Fliedner","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus Liebig University and UKGM, Giessen, 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