{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:11:48Z","timestamp":1768003908886,"version":"3.49.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction Severe acquired hypothyroidism in childhood is a rare\n                    condition, mostly caused by autoimmune thyroiditis. Scarce and inconsistent data\n                    based on small patient numbers exist concerning its impact on growth in\n                    height.<\/jats:p><jats:p>\n          Methods Patient files at a single centre university hospital over 8 years\n                    were retrospectively reviewed. We identified 43 patients (mean age 10.6 years,\n                    3.3\u201315.25, 59% prepubertal, 88% females) in a cohort of\n                    children older than 3 years with an initial TSH&gt;30 mIU\/l and\n                    reduced T4 or fT4; congenital and drug-induced hypothyroidism were excluded.<\/jats:p><jats:p>\n          Results All patients had signs of autoimmune thyroiditis (93%\n                    positive autoantibodies, 95% typical ultrasonography, 63%\n                    goiter). Median TSH was 100 mIU\/l [0.3\u20134 mIU\/l]), median\n                    fT4 3.55\u2009pg\/ml [8\u201319\u2009pg\/ml], median T4\n                    2.85\u2009\u00b5g\/dl\n                    [5.3\u201311\u2009\u00b5g\/dl]. Presenting symptoms included\n                    goiter (26%), tiredness (23%), weight gain (19%), and\n                    growth retardation (19%). The diagnosis was made incidentally in\n                    26% patients. In 75% growth was retarded (median height standard\n                    deviation score (SDS)-0.55), in 17% height SDS was&lt;-2 at\n                    diagnosis. Midparental height SDS at diagnosis correlated significantly with T4\n                    and fT4 (r=0.77, p=0.0012 and r=0.53, p=0.021\n                    respectively). Catch-up growth under T4 substitution was significantly greater\n                    in prepubertal than in pubertal children (p 0.049).<\/jats:p><jats:p>\n          Conclusion This so far largest pediatric cohort with severe acquired\n                    hypothyroidism confirms a serious impact on growth which, however in most cases,\n                    showed a certain catch-up growth after adequate L-thyroxine therapy. The\n                    pubertal state seems to be important for catch-up growth. A significant number\n                    of patients were not diagnosed clinically, although affected by severe\n                    hypothyroidism.<\/jats:p>","DOI":"10.1055\/a-1538-8241","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T01:18:53Z","timestamp":1633396733000},"page":"217-222","source":"Crossref","is-referenced-by-count":8,"title":["Severe Acquired Primary Hypothyroidism in Children and its Influence\n                    on Growth: A Retrospective Analysis of 43 Cases"],"prefix":"10.1055","volume":"130","author":[{"given":"Marianne","family":"Becker","sequence":"additional","affiliation":[{"name":"Sozial-P\u00e4diatrisches Zentrum, Charit\u00e9\n                    Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Blankenstein","sequence":"additional","affiliation":[{"name":"Institute for Experimental Pediatric Endocrinology, Charit\u00e9\n                    Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Lankes","sequence":"additional","affiliation":[{"name":"Sozial-P\u00e4diatrisches Zentrum, Charit\u00e9\n                    Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Schnabel","sequence":"additional","affiliation":[{"name":"Sozial-P\u00e4diatrisches Zentrum, Charit\u00e9\n                    Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Krude","sequence":"additional","affiliation":[{"name":"Institute for Experimental Pediatric Endocrinology, Charit\u00e9\n                    Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/adc.83.3.207","article-title":"Prevalence and aetiology of hypothyroidism in the young","volume":"83","author":"I Hunter","year":"2000","journal-title":"Arch Dis Child"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4003","article-title":"Iodine deficiency and hypothyroidism from voluntary diet restrictions in the US:\n                    case reports","volume":"137","author":"S Booms","year":"2016","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3928\/0090-4481-19920101-07","article-title":"Thyroiditis and acquired hypothyroidism","volume":"21","author":"S Lafranchi","year":"1992","journal-title":"Pediatr 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