{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T10:48:54Z","timestamp":1772275734899,"version":"3.50.1"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Lokalisierte, solit\u00e4re fibr\u00f6se Tumoren sind eine seltene Entit\u00e4t und finden sich meist im Thorax, k\u00f6nnen aber auch in Leber, Haut, Meningen, am Peritoneum und Perikard auftreten. Aufgrund des vielgestaltigen mikromorphologischen Erscheinungsbildes ist die Sicherung der Diagnose oftmals schwierig. Entscheidend ist die histopathologische Begutachtung mit differenzierter Immunhistochemie. Die chirurgische Resektion der lokalisierten, solit\u00e4ren fibr\u00f6sen Tumoren ist die Therapie der Wahl. Die Rezidiv- und Metastasenrate ist abh\u00e4ngig von der histologischen Dignit\u00e4t insgesamt sehr gering. Kontinuierliche Nachsorgeuntersuchungen sind indiziert.<\/jats:p><jats:p>Wir berichten \u00fcber eine 76-j\u00e4hrigen Patientin mit einem monstr\u00f6sen solit\u00e4ren fibr\u00f6sen Tumor der Pleura, die seit einigen Wochen \u00fcber Belastungsdyspnoe und stechende Schmerzen rechts thorakal klagte. Computertomografisch zeigte sich eine heterogene Raumforderung mit ca. 22\u200acm Durchmesser im Mittel- und Unterfeld des Thorax mit Kompression des Zwerchfells und des Mediastinums. Der Tumor wurde \u00fcber eine doppelte Thorakotomie im 5. und im 8.\u2006Interkostalraum vollst\u00e4ndig reseziert. Intraoperativ zeigte sich der Tumor zum Mittellappen gestielt. Um den Tumor vollst\u00e4ndig zu entfernen, wurde zus\u00e4tzlich eine Keilresektion aus dem Mittellappen durchgef\u00fchrt. Der Tumor wog 2,4\u200akg. Die Diagnose eines solit\u00e4ren fibr\u00f6sen Tumors der Pleura wurde histologisch und immunhistochemisch gestellt. Postoperativ hat sich die Lunge vollst\u00e4ndig entfaltet. Bei der 3-monatigen Nachuntersuchung zeigte sich kein Nachweis eines Rezidivs. Die klinische Symptomatik, Diagnosestellung, Therapieoptionen, Rezidivrisiko und die Prognose dieser Tumore werden aufgezeigt und entsprechend der Literatur diskutiert.<\/jats:p>","DOI":"10.1055\/a-1542-7201","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:48:34Z","timestamp":1627692514000},"page":"47-53","source":"Crossref","is-referenced-by-count":1,"title":["Monstr\u00f6ser solit\u00e4rer fibr\u00f6ser Tumor der Pleura"],"prefix":"10.1055","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1278-559X","authenticated-orcid":false,"given":"Georgi","family":"Prisadov","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Thoraxchirurgie, Kliniken Maria Hilf, M\u00f6nchengladbach"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Hendrix","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Thoraxchirurgie, Kliniken Maria Hilf, M\u00f6nchengladbach"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Kamlak","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Thoraxchirurgie, Kliniken Maria Hilf, M\u00f6nchengladbach"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Welcker","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Thoraxchirurgie, Kliniken Maria Hilf, M\u00f6nchengladbach"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"ref1","first-page":"385","article-title":"Primary neoplasms of the pleura","volume":"16","author":"P Klemperer","year":"1931","journal-title":"Arch Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1002\/1097-0142(19810601)47:11<2678::AID-CNCR2820471126>3.0.CO;2-9","article-title":"Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature","volume":"47","author":"M Briselli","year":"1981","journal-title":"Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/00000478-198908000-00003","article-title":"Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases","volume":"13","author":"D M England","year":"1989","journal-title":"Am J Surg Pathol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.12.004","article-title":"Programmed Death Ligand 1 and Immune Cell Infiltrates in Solitary Fibrous Tumors of the Pleura","author":"L F Tapias","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/MCP.0b013e328352f696","article-title":"Solitary \ufb01brous tumors of the pleura","volume":"18","author":"G Cardillo","year":"2012","journal-title":"Curr Opin Pulm Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0003-4975(01)03374-4","article-title":"Solitary \ufb01brous tumors of the pleura","volume":"74","author":"M De Perrot","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0022-5223(19)41262-2","article-title":"Localized mesothelioma of the pleura. Benign and malignant variants","volume":"75","author":"N Okike","year":"1978","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s00104-003-0764-x","article-title":"Gro\u00dfe solit\u00e4re fibr\u00f6se Tumoren der Pleura als Zufallsbefund \u2013 Zwei Kasuistiken zu einer Tumorrarit\u00e4t","volume":"75","author":"R Schwab","year":"2004","journal-title":"Chirurg"},{"key":"ref9","first-page":"1034","article-title":"Extrapleural Solitary Fibrous Tumor: A Clinicopathologic Study of 24 Cases","volume":"12","author":"R B Brunnmann","year":"1999","journal-title":"Modern Pathology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1515\/med-2016-0042","article-title":"Integrated therapeutic approach to giant solitary \ufb01brous tumor of the pleura: Report of a case and review of the literature","volume":"11","author":"F Perrotta","year":"2016","journal-title":"Open Med (Wars)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/ejcts\/ezr009","article-title":"Solitary \ufb01brous tumours of the pleura","volume":"41","author":"W Abu Arab","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0046-8177(95)90145-0","article-title":"CD-34 and keratin expression distinguishes solitary fibrous tumor (fibrous mesothelioma) of pleura from desmoplastic mesothelioma","volume":"26","author":"A Flint","year":"1995","journal-title":"Hum Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/cncr.10328","article-title":"Clinicopathologic Correlates of Solitary Fibrous Tumors","volume":"94","author":"S Gold Jason","year":"2002","journal-title":"Cancer"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1097\/00000478-199812000-00007","article-title":"Atypical and malignant solitary fibrous tumor in extrathoracic locations; evidence of their comparability to intra-thoracic tumors","volume":"22","author":"A V Vallat-Decouvelaere","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1055\/s-2008-1076789","article-title":"Solit\u00e4re fibr\u00f6se Tumoren der Pleura \u2013 Klinik und Prognose","volume":"133","author":"S Dango","year":"2008","journal-title":"Zentralbl Chir"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12931-017-0693-8","article-title":"Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score \u2013 a multicenter study","volume":"16","author":"M Diebold","year":"2017","journal-title":"Respir Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1365-2559.1998.00412.x","article-title":"Solitary fibrous tumour: significance of p53 and CD34 immunoreactivity in its malignant transformation","volume":"32","author":"T Yokoi","year":"1998","journal-title":"Histopathology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"368","DOI":"10.12659\/PJR.890525","article-title":"Solitary \ufb01brous tumour of the pleura cases analysis","volume":"79","author":"P Jadczak","year":"2014","journal-title":"Pol J Radiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.athoracsur.2004.07.013","article-title":"Solitary \ufb01brous tumors of the pleura: surgical outcome and clinical course","volume":"79","author":"S H Sung","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1010-7940(00)00636-9","article-title":"Solitary fibrous tumour of the pleura: surgical treatment","volume":"19","author":"O Rena","year":"2001","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0022-5223(00)70242-X","article-title":"Solitary fibrous tumor associated with hypoglycemia: an example of the Doege-Potter syndrome","volume":"119","author":"M H Chamberlain","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref22","first-page":"559","article-title":"Severo hypoglycaemia associated with a giant solitary fibrous tumor of the pleura","volume":"43","author":"P L Filosso","year":"2002","journal-title":"J Cardiovasc Surg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.crad.2017.03.028","article-title":"Solitary fibrous tumour of pleura: CT differentiation of benign and malignant types","volume":"72","author":"A Gupta","year":"2017","journal-title":"Clin Radiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00408-003-1002-5","article-title":"[(18)F]-FDG-PET and localized fibrous mesothelioma","volume":"181","author":"J Cortes","year":"2003","journal-title":"Lung"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.crad.2004.08.015","article-title":"Recurrent solitary fibrous tumor of the pleura due to tumour seeding following ultrasoundguided transthoracic biopsy","volume":"60","author":"A F Scarsbrook","year":"2005","journal-title":"Clin Radiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jtcvs.2009.01.026","article-title":"Solitary \ufb01brous tumors of the pleura: results of surgical treatment and long-term prognosis","volume":"138","author":"K M Harrison-Phipps","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1159\/000484041","article-title":"Durable Near-Complete Response to Anti-PD-1 Checkpoint Immunotherapy in a Refractory Malignant Solitary Fibrous Tumor of the Pleura","volume":"10","author":"J T Boothea","year":"2017","journal-title":"Case Rep Oncol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S1010-7940(02)00099-4","article-title":"Solitary fibrous tumors of the pleura: clinical characteristics, surgical treatment and outcome","volume":"21","author":"P Magdeleinat","year":"2002","journal-title":"Eur J Cardiothorac Surg"}],"container-title":["Pneumologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1542-7201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T01:51:03Z","timestamp":1643161863000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1542-7201"}},"subtitle":["Eine Fallvorstellung und 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