{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:09:25Z","timestamp":1781658565001,"version":"3.54.5"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"Information The study was supported by Erciyes University Scientific\n                    Research Council","award":["TTU-2013-4566"],"award-info":[{"award-number":["TTU-2013-4566"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to evaluate the sleep parameters of patients\n                    with Cushing syndrome (CS) at the time of diagnosis and 12-months after\n                    treatment. Thirty four newly diagnosed patients with endogenous CS (17 with\n                    ACTH-secreting pituitary adenoma, 17 with adrenal CS) and 23 controls with\n                    similar age were included in the study. Two polysomnography (PSG) recordings\n                    were performed; one at the time of diagnosis and the other 12 months after\n                    resolution of hypercortisolemia. Control group had only baseline PSG. Based on\n                    the PSG findings, stage N2 sleep was found to be prolonged, stage N3 and REM\n                    sleep were shortened in patients with CS. Average heart rate and mean Apnea\n                    Hypopnea Index (AHI) score were higher in patients with CS than the control\n                    subjects. Sixteen (47.1%) patients with CS and 4 (17.4%)\n                    controls had obstructive sleep apnea (OSA; AHI \u22655). There were no\n                    significant differences in sleep parameters of patients according to the\n                    etiology of CS (adrenal vs. pituitary) patients. Following 12-months of\n                    treatment, a significant decrease in stage N2 sleep and a significant increase\n                    in stage N3 sleep were detected, but there was no change in terms of AHI. In\n                    conclusion, Cushing syndrome has disturbing effects on sleep structure and these\n                    effects are at least partially reversible after treatment. However, the\n                    increased risk of OSA was not reversed a year after treatment indicating the\n                    importance of early diagnosis and treatment of CS.<\/jats:p>","DOI":"10.1055\/a-1542-8816","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T22:30:27Z","timestamp":1631140227000},"page":"608-615","source":"Crossref","is-referenced-by-count":6,"title":["Cushing Syndrome is Associated with Increased Stage N2 Sleep and\n                    Decreased SWS Partially Reversible After Treatment"],"prefix":"10.1055","volume":"53","author":[{"given":"Sevda","family":"Ismailogullari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erciyes University Medical School, Kayseri,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuleyha","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Erciyes University Medical School,\n                    Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedat Tarik","family":"Firat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Erciyes University Medical School,\n                    Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kursad","family":"Unluhizarci","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Erciyes University Medical School,\n                    Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahrettin","family":"Kelestimur","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Yeditepe University Medical School,\n                    Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-981-15-7086-5_8","volume-title":"Neural circuits for sleep-wake regulation. 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1542-8816.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T22:32:33Z","timestamp":1631140353000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1542-8816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":38,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2021,9,8]]},"published-print":{"date-parts":[[2021,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1542-8816","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}