{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:24:08Z","timestamp":1793381048598,"version":"4.5.0"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading; however, the WHO classification does not recommend any specific grading system. VIN are also differentiated according to whether they are HPV(p16)-associated. HPV-independent adenocarcinoma (AC) of the cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression is considered to be a surrogate marker for HPV association. HPV-associated AC of the cervix uteri is determined using the prognostically relevant Silva pattern.<\/jats:p>","DOI":"10.1055\/a-1545-4279","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T18:48:12Z","timestamp":1633546092000},"page":"1145-1153","source":"Crossref","is-referenced-by-count":389,"title":["2020 WHO Classification of Female Genital Tumors"],"prefix":"10.1055","volume":"81","author":[{"given":"Anne Kathrin","family":"H\u00f6hn","sequence":"additional","affiliation":[{"name":"Arbeitsgruppe Mamma, Gyn\u00e4ko- & Perinatalpathologie, Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Leipzig A\u00f6R, Leipzig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Brambs","sequence":"additional","affiliation":[{"name":"Frauenklinik, Kantonsspital, Luzern, Schweiz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grit Gesine Ruth","family":"Hiller","sequence":"additional","affiliation":[{"name":"Arbeitsgruppe Mamma, Gyn\u00e4ko- & Perinatalpathologie, Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Leipzig A\u00f6R, Leipzig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"May","sequence":"additional","affiliation":[{"name":"Pathologisches Institut der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Schmoeckel","sequence":"additional","affiliation":[{"name":"Pathologisches Institut der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars-Christian","family":"Horn","sequence":"additional","affiliation":[{"name":"Arbeitsgruppe Mamma, Gyn\u00e4ko- & Perinatalpathologie, Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Leipzig A\u00f6R, 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