{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T03:47:17Z","timestamp":1768103237516,"version":"3.49.0"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund\u2002Fortbestehende Beschwerden und \u00e4rztlich validierte Diagnosen nach COVID-19 sind bislang nicht gut definiert. Wir berichten \u00fcber Symptome und Diagnostik bei Patienten in unserer COVID-19-Nachsorgeambulanz.<\/jats:p><jats:p>\n          Methoden\u2002Es erfolgte eine retrospektive Analyse der Beschwerden und Befunde bei erwachsenen Patienten nach labordiagnostisch gesicherter COVID-19-Erkrankung mit \u00fcber mindestens 6 Monate fortbestehenden Beschwerden. Neben Anamnese, k\u00f6rperlicher Untersuchung und Labordiagnostik erfolgte eine symptomgeleitete erweiterte apparative Diagnostik. Die Lebensqualit\u00e4t wurde mittels SF-36-Fragebogens erfasst.<\/jats:p><jats:p>\n          Ergebnisse\u2002132 Patienten mit \u00fcber mindestens 6 Monate persistierenden Beschwerden wurden in die Auswertung eingeschlossen (58 m\u00e4nnlich, 74 weiblich; mittleres Alter 53,8 Jahre). 40\u200a% der Patienten waren in der Akutphase station\u00e4r behandelt worden. Die h\u00e4ufigsten Beschwerden waren Fatigue (82\u200a%), Belastungsdyspnoe (61\u200a%), kognitive Beschwerden (54\u200a%), Schlafst\u00f6rungen (43\u200a%) und Dysgeusie\/-osmie (35\u200a%). Die Lebensqualit\u00e4t war in allen im SF-36 abgefragten Bereichen eingeschr\u00e4nkt. Immerhin 23\u200a% der zuvor Berufst\u00e4tigen waren aus gesundheitlichen Gr\u00fcnden f\u00fcr mindestens 6 Monate arbeitsunf\u00e4hig. Signifikante Pathologien in der laborchemischen und apparativen Diagnostik waren insbesondere bei ambulant behandelten Patienten dagegen selten; Lungenfunktionsst\u00f6rungen waren h\u00e4ufiger bei ehemals station\u00e4r behandelten Patienten.<\/jats:p><jats:p>\n          Diskussion\/Schlussfolgerungen\u2002Patienten nach COVID-19 berichten \u00fcber vielf\u00e4ltige Symptome, f\u00fcr die h\u00e4ufig kein organpathologisches Korrelat gefunden werden kann. Dies geht mit Einschr\u00e4nkungen der Lebensqualit\u00e4t und Arbeitsf\u00e4higkeit, auch 6 Monate nach Akutinfektion, einher. Populationsbasierte Pr\u00e4valenz, Pathogenese, Langzeitverlauf und Therapiem\u00f6glichkeiten dieses vielfach als Long COVID bezeichneten Syndroms sind weitgehend ungekl\u00e4rt. Aufgrund der vielf\u00e4ltigen Beschwerden sollte die Patientenversorgung interdisziplin\u00e4r erfolgen und vermehrt Leistungsdiagnostik und systematische neuropsychiatrische Tests beinhalten.<\/jats:p>","DOI":"10.1055\/a-1546-4291","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T22:54:35Z","timestamp":1629759275000},"page":"e65-e73","source":"Crossref","is-referenced-by-count":5,"title":["Persistierende Beschwerden 6 Monate nach COVID-19 \u2013 Erfahrungen aus der COVID-19-Nachsorgeambulanz des Universit\u00e4tsklinikums Freiburg"],"prefix":"10.1055","volume":"146","author":[{"given":"Dietrich","family":"August","sequence":"first","affiliation":[{"name":"Klinik fu\u0308r Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Stete","sequence":"first","affiliation":[{"name":"Klinik fu\u0308r Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Kern","sequence":"first","affiliation":[{"name":"Klinik fu\u0308r Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegbert","family":"Rieg","sequence":"first","affiliation":[{"name":"Klinik fu\u0308r Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Hilger","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Biever","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"},{"name":"Klinik f\u00fcr Innere Medizin III \u2013 Medizinische Intensivmedizin, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Hosp","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Neurologie und Neurophysiologie, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Wagner","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Christian","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Pneumologie, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Gerstacker","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Seufert","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Laubner","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1001\/jama.2020.12603","article-title":"Persistent Symptoms in Patients After Acute COVID-19","volume":"324","author":"A Carf\u00ec","year":"2020","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0140-6736(20)32656-8","article-title":"6-month consequences of COVID-19 in patients discharged from hospital: a cohort study","volume":"397","author":"C Huang","year":"2021","journal-title":"The Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s00103-013-1700-y","article-title":"Gesundheitsbezogene Lebensqualit\u00e4t bei Erwachsenen in Deutschland: Ergebnisse der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1)","volume":"56","author":"U Ellert","year":"2013","journal-title":"Bundesgesundheitsbl"},{"key":"ref6","first-page":"A-2416","article-title":"Long COVID: Der lange Schatten von COVID-19","volume":"117","author":"M Lenzen-Schulte","year":"2020","journal-title":"Dtsch Arztebl International"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1101\/2021.01.27.21250617","article-title":"More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis","author":"S Lopez-Leon","year":"2021","journal-title":"medRxiv"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.5612","article-title":"Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers","author":"S Havervall","year":"2021","journal-title":"JAMA"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1750","article-title":"Comprehensive health assessment three months after recovery from acute COVID-19","author":"B van den Borst","year":"2020","journal-title":"Clinical Infectious Diseases"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e0247461","DOI":"10.1371\/journal.pone.0247461","article-title":"Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis","volume":"16","author":"A Booth","year":"2021","journal-title":"PLoS ONE"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1056\/NEJMoa1011802","article-title":"Functional disability 5 years after acute respiratory distress syndrome","volume":"364","author":"M S Herridge","year":"2011","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1378\/chest.11-2196","article-title":"Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDS","volume":"142","author":"C E Luyt","year":"2012","journal-title":"Chest"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1164\/ajrccm.150.1.8025779","article-title":"Recovery of function in survivors of the acute respiratory distress syndrome","volume":"150","author":"L G McHugh","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab009","article-title":"Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19","author":"J A Hosp","year":"2021","journal-title":"Brain"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262128","article-title":"Slow but evident recovery from neocortical dysfunction and cognitive impairment in a series of chronic COVID-19 patients","author":"G Blazhenets","year":"2021","journal-title":"J Nucl Med"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1546-4291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:18:04Z","timestamp":1630023484000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1546-4291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,23]]},"references-count":13,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2021,8,26]]},"published-print":{"date-parts":[[2021,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1546-4291","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,23]]}}}