{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:14Z","timestamp":1740126854715,"version":"3.37.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Trabeculectomy (TE) has been the standard procedure in glaucoma surgery for a long time. This study examined the efficacy and safety profile of XEN45 Gel Stent (XEN) after failed and\/or scarred trabeculectomy.<\/jats:p><jats:p>\n          Material and Methods We analysed all files of patients, who received a XEN after insufficient TE and examined changes in intraocular pressure (IOP), IOP-lowering medication, best corrected visual acuity, visual field tests as well as the intra- and postoperative complications recorded within a 12-month follow-up period.<\/jats:p><jats:p>\n          Results 31 eyes of 28 patients were analysed in our study (mean age: 66,2\u2009\u00b1\u200913,4 years; 39% female; 48% right eye; mean follow-up after TE: 70,3\u2009\u00b1\u200964,9 months). The mean IOP decreased from 23,5\u2009\u00b1\u20096,5 to 18,0\u2009\u00b1\u20095,3\u2009mmHg (\u2212\u200923,5% compared to baseline-IOP; p\u2009=\u20090,01) while the mean IOP-lowering medication could be reduced from 2,8\u2009\u00b1\u20091,1 to 1,1\u2009\u00b1\u20091,5 (p\u2009&lt;\u20090,01) 12 months after XEN-implantation. The mean visual acuity did not change significantly (pre-op: 0,5\u2009\u00b1\u20090,6\u2009logMAR; 12 months post-op: 0,5\u2009\u00b1\u20090,6\u2009logMAR). The most common complications postoperatively were choroideal detachment due to postoperative hypotony in 4 eyes (13%), a needling procedure in 9 eyes (29%), a Re-XEN-Implantation in 4 eyes (13%), an open revision of the conjunctiva in 3 eyes (10%), and a Re-TE in 1 eye (3%) as well as an Ahmed-Valve implantation in 2 eyes (6%). Overall, neither needling procedure nor further glaucoma surgery was necessary in 19 eyes (61%). In 10 of 22 evaluable eyes (45%) an\n\t\t\t\t\tIOP reduction of &gt;\u200920% was achieved 12 months after XEN implantation.<\/jats:p><jats:p>\n          Conclusion XEN could be an effective method to reduce IOP after failed TE. The rate of complications seems to be low and the rate of needling procedures and\/or revisions is acceptable.<\/jats:p>","DOI":"10.1055\/a-1553-4547","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T22:50:15Z","timestamp":1632783015000},"page":"86-93","source":"Crossref","is-referenced-by-count":5,"title":["Implantation of XEN After Failed Trabeculectomy: an Efficient Therapy?"],"prefix":"10.1055","volume":"239","author":[{"given":"Caroline","family":"Bormann","sequence":"additional","affiliation":[{"name":"Klinik & Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinik Leipzig, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Klinik & Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinik Leipzig, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina","family":"Busch","sequence":"additional","affiliation":[{"name":"Klinik & Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinik Leipzig, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matus","family":"Rehak","sequence":"additional","affiliation":[{"name":"Klinik & Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinik Leipzig, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Thomas","family":"Scharenberg","sequence":"additional","affiliation":[{"name":"Augenheilkunde, Augen\u00e4rzte am Kurpark, L\u00fcneburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1469-0412","authenticated-orcid":false,"given":"Jan Darius","family":"Unterlauft","sequence":"additional","affiliation":[{"name":"Klinik & Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinik Leipzig, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e1221","DOI":"10.1136\/bjophthalmol-2017-311258","article-title":"Global causes of blindness and distance vision impairment 1990\u20132020: a systematic review and meta-analysis","volume":"12","author":"S R Flaxman","year":"2017","journal-title":"Lancet Glob Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Y C Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref3","first-page":"225","article-title":"The Diagnosis and Treatment of Glaucoma","volume":"13","author":"A K Schuster","year":"2020","journal-title":"Dtsch Arztebl 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II. Variations in operative technique and outcome","volume":"4","author":"B Edmunds","year":"2001","journal-title":"Eye (Lond)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/sj.eye.6700148","article-title":"The National Survey of Trabeculectomy. III. 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Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1553-4547.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T06:11:31Z","timestamp":1644214291000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1553-4547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,27]]},"references-count":30,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,2,4]]},"published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1553-4547","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"type":"print","value":"0023-2165"},{"type":"electronic","value":"1439-3999"}],"subject":[],"published":{"date-parts":[[2021,9,27]]}}}