{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T18:42:37Z","timestamp":1722883357302},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired clonal haematological disease characterized by complement-mediated haemolysis, bone marrow failure and venous thrombosis. Anticomplement therapy eculizumab improves survival and reduces complications. Severe acute respiratory distress syndrome corona virus 2 (SARS-CoV-2) disease 2019 (COVID-19) is associated with high incidence of both venous and arterial thrombosis in hospitalized patients with pneumonia. Deep venous thrombosis (DVT) as the presenting symptom of COVID-19 is a rare event. We describe a well-controlled PNH patient on eculizumab for more than 5 years who presented with DVT, while on warfarin, as the first sign of COVID-19. To our knowledge, this is the first described case of DVT in a PNH patient with COVID-19.<\/jats:p>","DOI":"10.1055\/a-1554-6432","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T23:23:55Z","timestamp":1632180235000},"page":"397-399","source":"Crossref","is-referenced-by-count":3,"title":["COVID-19 Presented with Deep Vein Thrombosis in a Patient with Paroxysmal Nocturnal Haemoglobinuria"],"prefix":"10.1055","volume":"41","author":[{"given":"Zlatko","family":"Pravdic","sequence":"additional","affiliation":[{"name":"Clinic of Haematology, University Clinical Centre of Serbia, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjana","family":"Mitrovic","sequence":"additional","affiliation":[{"name":"Clinic of Haematology, University Clinical Centre of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrija","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"Clinic of Haematology, University Clinical Centre of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Virijevic","sequence":"additional","affiliation":[{"name":"Clinic of Haematology, University Clinical Centre of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikica","family":"Sabljic","sequence":"additional","affiliation":[{"name":"Clinic of Haematology, University Clinical Centre of Serbia, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"Pantic","sequence":"additional","affiliation":[{"name":"Clinic of Haematology, University Clinical Centre of Serbia, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada Suvajdzic","family":"Vukovic","sequence":"additional","affiliation":[{"name":"Clinic of Haematology, University Clinical Centre of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"issue":"02","key":"ref1","first-page":"205","article-title":"Paroxysmal nocturnal hemoglobinuria: pathophysiology, natural history and treatment options in the era of biological agents","volume":"2","author":"A M Risitano","year":"2008","journal-title":"Biologics"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-2141.2011.08690.x","article-title":"Management of paroxysmal nocturnal haemoglobinuria: a personal view","volume":"153","author":"L 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