{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:59:59Z","timestamp":1788476399297,"version":"build-2803163510"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002Quality of life (QoL) is significantly impaired in patients with pulmonary fibrosis, however reliable tools to assess QoL issues specific for this group of patients are still missing. We thus aimed to develop a new questionnaire called \u201cQuality of life in patients with idiopathic pulmonary fibrosis\u201d (QPF) to measure QoL in patients with fibrotic idiopathic interstitial pneumonias (IIP).<\/jats:p><jats:p>\n          Methods\u2002An item pool was created on the basis of a German expert group with support of patients suffering from pulmonary fibrosis. In a 1st step, this version of the questionnaire was completed by 52 patients with idiopathic pulmonary fibrosis (IPF) or non-specific interstitial pneumonia (NSIP). Following this, an item- and an exploratory factor analysis was carried out and a 2nd version created. In a multicenter validation study in a one-group pre-post design, the questionnaire was filled in by 200 patients with IIP (IPF\u200a=\u200a190, iNSIP\u200a=\u200a10) at 2 time points with an interval of 6 months. Cross-validation was carried out with the St. Georges Respiratory Questionnaire (SGRQ).<\/jats:p><jats:p>\n          Results\u2002The mean age of the patients was 71.0 years (50\u201390 years), 82.5\u200a% were male. Item analysis revealed that most of Cronbach alpha and selectivity values of QPF-scales could be considered as sufficient (e.\u200ag. QPF-scale \u201ccondition\u201d [alpha\u200a=\u200a0.827], \u201cimpairment\u201d [alpha\u200a=\u200a0.882]). At scale level, there were significant differences in terms of a deterioration or improvement in the QPF-condition and QPF-breathlessness scales and also in the SGRQ-activity scale. Analysis of construct validation of QPF and SGRQ showed moderate correlations between both questionnaires. A deterioration in health status from the patient\u2019s and doctor\u02bcs perspective was seen in the scales \u201cimpairment\u201d, \u201cshortness of breath\u201d and \u201chealth status\u201d of the QPF. The QPF was able to detect a change in the patient\u02bcs mood (\u201ccondition\u201d scale) in the course of treatment.<\/jats:p><jats:p>\n          Conclusion\u2002This newly developed questionnaire maps the special needs of the patients well. The QPF is suitable for screening of quality of life as well as for supplementing the medical history and for monitoring the course of disease in fibrotic IIPs.<\/jats:p>","DOI":"10.1055\/a-1579-7618","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T22:48:46Z","timestamp":1631659726000},"page":"25-34","source":"Crossref","is-referenced-by-count":6,"title":["A New Tool to Assess Quality of Life in Patients with Idiopathic Pulmonary Fibrosis or Non-specific Interstitial Pneumonia"],"prefix":"10.1055","volume":"76","author":[{"given":"Detlef","family":"Kirsten","sequence":"additional","affiliation":[{"name":"LungenClinic, Gro\u00dfhansdorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"de Vries","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Klinische Psychologie und Rehabilitation der Universit\u00e4t Bremen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Costabel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pneumologie, Ruhrlandklinik, Universit\u00e4tsmedizin Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Koschel","sequence":"additional","affiliation":[{"name":"Fachkrankenhaus Coswig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bonella","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pneumologie, Ruhrlandklinik, Universit\u00e4tsmedizin Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Fachkrankenhaus Waldhof Elgershausen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Behr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V, LMU Klinikum, University of Munich and German Center for Lung Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Claussen","sequence":"additional","affiliation":[{"name":"LungenClinic, Gro\u00dfhansdorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Asklepios Klinikum Harburg, Lungen-Abteilung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Prasse","sequence":"additional","affiliation":[{"name":"Medizinische Hochschule Hannover, Klinik f\u00fcr Pneumologie; Pneumologie und Beatmungsmedizin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kreuter","sequence":"additional","affiliation":[{"name":"Center for interstitial and rare lung diseases, Pneumology, Thoraxklinik, University of Heidelberg and German Center for Lung ResearchHeidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1164\/ajrccm.161.2.ats3-00","article-title":"European Respiratory Society. Idiopathic pulmonary fibrosis: diagnosis and treatment: international consensus statement","volume":"161","author":"American Thoracic Society","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management","volume":"183","author":"G Raghu","year":"2011","journal-title":"Am Resp Crit Care Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1902279","DOI":"10.1183\/13993003.02279-2019","article-title":"Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the INSIGHTS-IPF registry","volume":"56","author":"J Behr","year":"2020","journal-title":"Eur Respir J"},{"key":"ref4","first-page":"195021","article-title":"The therapy of idiopathic pulmonary fibrosis: what is next?","volume":"28","author":"V Somogyi","year":"2019","journal-title":"Eur Resp Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1055\/s-0043-106160","article-title":"S2k-Leitlinie Idiopathische Lungenfibrose - Update zur medikament\u00f6sen Therapie 2017","volume":"71","author":"J Behr","year":"2017","journal-title":"Pneumologie"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMoa1402582","article-title":"A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis","volume":"370","author":"T E King jr","year":"2014","journal-title":"N Eng J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1056\/NEJMoa1103690","article-title":"Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis","volume":"365","author":"L Richeldi","year":"2011","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12890-017-0444-0","article-title":"Prognosis and longitudinal changes of physical activity in idiopathic pulmonary fibrosis","volume":"25","author":"T Bahmer","year":"2017","journal-title":"BMC Pulm Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1378\/chest.116.5.1175","article-title":"Assessment of health-related quality of life in patients with interstitial lung disease","volume":"116","author":"J A Chang","year":"2012","journal-title":"Chest"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1183\/09031936.01.17509540","article-title":"Quality of life of idiopathic pulmonary fibrosis patients","volume":"17","author":"J De Vries","year":"2001","journal-title":"Eur Resp J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/rmed.1999.0736","article-title":"Assessing health status and quality of life in idiopathic pulmonary fibrosis: which measure should be used?","volume":"94","author":"J De Vries","year":"2001","journal-title":"Respir Med"},{"key":"ref12","first-page":"A1439","article-title":"Quality of life of patients with idiopathic pulmonary fibrosis (IPF) \u2013 what can the Australian IPF registry tell us?","volume":"189","author":"I Glaspole","year":"2014","journal-title":"Am J Resp Crit Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1164\/ajrccm.164.7.2003140","article-title":"Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model","volume":"164","author":"T E King Jr","year":"2001","journal-title":"Am J Resp Crit Care Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12931-019-1020-3","article-title":"The clinical course of idiopathic pulmonary fibrosis and its association to quality of life over time: longitudinal data from the INSIGHTS-IPF registry","volume":"20","author":"M Kreuter","year":"2019","journal-title":"Resp Research"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12931-017-0621-y","article-title":"Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: INSIGHTS-IPF registry","volume":"18","author":"M Kreuter","year":"2017","journal-title":"Resp Res"},{"key":"ref16","first-page":"1067","article-title":"A simple assessment of dyspnea as a prognostic indicator in idiopathic pulmonary fibrosis","volume":"36","author":"O Nishiyama","year":"2010","journal-title":"Eur J Res Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.rmed.2004.09.005","article-title":"Health-related quality of life in patients with idiopathic pulmonary fibrosis. What is the main contributing factor?","volume":"99","author":"O Nishiyamaa","year":"2005","journal-title":"Res Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1477-7525-3-61","article-title":"Patients\u02bc perspectives on how idiopathic pulmonary fibrosis affects the quality of their lives","volume":"3","author":"J J Swigris","year":"2005","journal-title":"Health Qual Life Outcomes"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1055\/s-0044-100207","article-title":"Patientenfragebogen zur Erfassung der Ursachen interstitieller und seltener Lungenerkrankungen \u2013 klinische Sektion der DGP","volume":"72","author":"M Kreuter","year":"2018","journal-title":"Pneumologie"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12931-019-1010-5","article-title":"Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis","volume":"20","author":"S Witt","year":"2019","journal-title":"Resp Res"},{"key":"ref21","first-page":"742","article-title":"Deutschsprachige Validierung des \u201eKing\u02bcs Brief Interstitial Lung Disease (K-BILD)\u201c. Lebensqualit\u00e4tsfragebogens f\u00fcr interstitielle Lungenerkrankungen","volume":"70","author":"M Kreuter","year":"2001","journal-title":"Pneumologie"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/thx.42.10.773","article-title":"A measure of quality of life for clinical trials of chronic lung disease","volume":"42","author":"G H Guyatt","year":"1987","journal-title":"Thorax"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0954-6111(06)80166-6","article-title":"The St. George\u02bcs Respiratory Questionnaire","volume":"85","author":"P W Jones","year":"1991","journal-title":"Resp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1136\/thx.56.6.482","article-title":"A survey of nocturnal hypoxaemia and health related quality of life in patients with cryptogenic fibrosing alveolitis","volume":"56","author":"M Clark","year":"2001","journal-title":"Thorax"},{"key":"ref25","first-page":"405","article-title":"Dyspnea scales as a measure of health-related quality of life in patients with idiopathic pulmonary fibrosis","volume":"8","author":"J AB Martinez","year":"2002","journal-title":"Med Sci Monit"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1378\/chest.117.6.1627","article-title":"Evaluation of the short-form 36-item questionnaire to measure health-related quality of life in patients with idiopathic pulmonary fibrosis","volume":"117","author":"T Y Martinez","year":"2000","journal-title":"Chest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e000278","DOI":"10.1136\/bmjresp-2018-000278","article-title":"Psychometric properties of the St George\u02bcs Respiratory Questionnaire in patients with idiopathic pulmonary fibrosis: insights from the INPULSIS trials","volume":"5","author":"J J Swigris","year":"2018","journal-title":"BMJ Open Respir Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1601788","DOI":"10.1183\/13993003.01788-2016","article-title":"Psychometric properties of the St George\u2019s Respiratory Questionnaire in patients with idiopathic pulmonary \ufb01brosis","volume":"49","author":"J J Swigris","year":"2017","journal-title":"Eur Respir J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1164\/rccm.202002-0415OC","article-title":"Development and Initial Validation Analyses of the Living with Idiopathic Pulmonary Fibrosis Questionnaire","volume":"15","author":"J J Swigris","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"ref30","first-page":"A5353","article-title":"Living with idiopathic pulmonary fibrosis (L-IPF): Developing a patient-reported symptom and impact questionnaire to assess health-related quality of life in IPF","volume":"195","author":"B Graney","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1378\/chest.11-1332","article-title":"Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease","volume":"142","author":"C E Berry","year":"2012","journal-title":"Chest"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1055\/a-1334-2745","article-title":"Linguistic validation of the \u201cGerman Lung Fibrosis Health Related Quality of Life Questionaire\u201d","author":"D Kirsten","year":"2021","journal-title":"Pneumologie"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1183\/13993003.02316-2014","article-title":"Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review","volume":"46","author":"G Raghu","year":"2015","journal-title":"Eur Res J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1183\/09031936.06.00037005","article-title":"High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis","volume":"27","author":"G Raghu","year":"2006","journal-title":"Eur Resp J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"187S","DOI":"10.1378\/chest.107.5_Supplement.187S","article-title":"Issues cocerning health-related quality of life in COPD","volume":"107","author":"P W Jones","year":"1995","journal-title":"Chest"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.rmed.2010.09.004","article-title":"Health-related quality of life in patients by COPD severity within primary care in Europe","volume":"105","author":"P W Jones","year":"2011","journal-title":"Respir Med"}],"container-title":["Pneumologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1579-7618.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T01:50:38Z","timestamp":1643161838000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1579-7618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":36,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,1,25]]},"published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1579-7618","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0934-8387","1438-8790"],"issn-type":[{"value":"0934-8387","type":"print"},{"value":"1438-8790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,14]]}}}